The protective effects of the combination of sodium ferulate and oxymatrine on ethanol-induced liver damage in mice

Pei, Xiaokun; Wang, Wei; Miao, Ningshu; Xu, Mengxin; Zhang, Chunlei; Sun, Mengmeng; Xu, Mingbo; Liu, Zhifeng

doi:10.1016/j.etap.2013.12.005

Cited by 17 publications

(10 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Treatment with sodium feulate and oxymatrine combination also significantly decreased the leukocyte number as well as the levels of IL-6, CRP and IFN-γ in the peritoneal lavage fluid induced by acetic acid, and its effect was better than that of each drug alone at doses equal to those in the medium combined group, which verified the results of previous studies by our group, which reported that sodium ferulate and oxymatrine combination significantly reduced the levels of IL-6, CRP and IFN-γ in serum or tissue homogenate of other mouse models (5,6,23). IL-6, a pro-inflammatory cytokine, has a vital role in the process of inflammation and macrophage activation (26)(27)(28).…”

Section: Fsc-supporting

confidence: 81%

“…Previous studies revealed that a combination of sodium ferulate and oxymatrine exerted synergistic anti-inflammatory effects (3)(4)(5)(6). The studies demonstrated that sodium ferulate and oxymatrine combination significantly inhibited xylene-induced edema in mouse ears and carrageenan-induced edema in rat paws.…”

Section: Introductionmentioning

confidence: 88%

“…The studies demonstrated that sodium ferulate and oxymatrine combination significantly inhibited xylene-induced edema in mouse ears and carrageenan-induced edema in rat paws. A mechanistic study revealed that the anti-inflammatory effects of sodium ferulate and oxymatrine combination was mainly associated with its modulatory effect on interleukin-6 (IL-6), IL-11, C-reactive protein (CRP) and interferon-γ (IFN-γ) in a RAW 264.7 cell model stimulated by lipopolysaccharides (4), which had also been verified in mouse models of cecal ligation and puncture-induced sepsis and enthanol-induced liver damage as well as in a RAW 264.7 cell model of lipopolysaccharide-stimulated damage (5,6).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

Sun

et al. 2017

Experimental and Therapeutic Medicine

Self Cite

View full text Add to dashboard Cite

Abstract. The present study aimed to investigate the anti-exudative effects of sodium ferulate combined with oxymatrine in a mouse model of acetic acid-induced peritonitis. Furthermore, the underlying mechanisms were explored by determining the effects of these drugs on the volume and aquaporin 1 (AQP1) expression in vascular endothelial cells on omentum majus and human umbilical vein endothelial cells (HUVEC). Treatment with sodium ferulate combined with oxymatrine was shown to significantly inhibit acetic acid-induced vascular permeability in the peritonitis model mice and furthermore to significantly decrease the optical density of Evans blue, the leukocyte number and the levels of interleukin-6, C-reactive protein and interferon-γ in peritoneal lavage fluid. Pathological analysis of the omentum majus revealed that sodium ferulate and oxymatrine combination treatment significantly alleviated vascular endothelial cell edema and capillary loss. In vitro, flow cytometry revealed that the volume of HUVECs was significantly reduced in the drug treatment groups, as reflected in the forward scatter value. The optical density of AQP1 on the membrane of the vascular endothelial cells on omentum majus and HUVECs were significantly increased in the drug treatment groups compared with the model group. These results indicated that sodium ferulate and oxymatrine combination treatment possessed prominent anti-exudative effects and that the underlying mechanisms are likely to include the improvement of vascular endothelial cellular edema, possibly by upregulation of AQP1 expression on their membrane, which requires further exploration.

show abstract

Section: Fsc-supporting

confidence: 81%

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

Sun

et al. 2017

Experimental and Therapeutic Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…ALT and AST levels correlated directly with the severity of hepatic fibrosis and cirrhosis. A combination of ferulic acid and OMT significantly reduces serum ALT and AST levels in alcohol-induced liver injury in rats 12 . Indoline derivatives significantly reduce serum ALT and AST levels in an acute liver injury mouse model 13 .…”

Section: ■ Discussionmentioning

confidence: 90%

The role of oxymatrine in regulating TGF-β1 in rats with hepatic fibrosis

Lin

Jin

et al. 2018

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…Examples include oxymatrine and luteolin both of which belong to the plant alkaloids/flavonoid family of chemicals [69,70] and locked antisense oligonucleotides. Oxymatrine is the active ingredient in the dried root of Sophora flavescens and is widely used for liver fibrosis in China [64,71,72]. This antifibrotic effect of oxymatrine appears to have been mediated by suppressing collagen gene transcription through translocation of the phosphorylated form of YB-1 from cytoplasm to nucleus, which is abrogated by siRNA to YB-1 [64].…”

Section: Antifibrotic Agentsmentioning

confidence: 99%

New Insights to Prevent Liver Fibrosis by Targeting YB-1 and Collagen Genes

Guntaka¹

2018

obm hg

View full text Add to dashboard Cite

Liver fibrosis leading to cirrhosis and cancer affects millions of people and causes thousands of deaths all over the world. Many signaling pathways could be targeted to block fibrosis but these are not successful. Reviewing recent literature and from our own studies we identified novel target, such as YB-1, which is implicated in inflammation, angiogenesis and accumulation of extracellular matrix (ECM). In addition we observed and showed that the end product of fibrosis, collagen gene, itself is a direct target for controlling fibrosis. We developed triplex-forming oligonucleotides which specifically form triplexes with the promoter of type I procollagen gene and effectively inhibited collagen accumulation and improved liver function. In this review we briefly described the potential of YB-1 and Collagen genes as excellent targets.

show abstract

The protective effects of the combination of sodium ferulate and oxymatrine on ethanol-induced liver damage in mice

Cited by 17 publications

References 23 publications

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

Anti-exudation effects of sodium ferulate and oxymatrine combination via modulation of aquaporin 1

The role of oxymatrine in regulating TGF-β1 in rats with hepatic fibrosis

New Insights to Prevent Liver Fibrosis by Targeting YB-1 and Collagen Genes

Contact Info

Product

Resources

About