The protective effects of sildenafil in acute lung injury in a rat model of severe scald burn: A biochemical and histopathological study

Gökakın, Ali Kağan; Deveci, Köksal; Kurt, Atilla; Karakuş, Boran Cihat; Düğer, Cevdet; Tuzçu, Mehmet; Topçu, Ömer

doi:10.1016/j.burns.2012.12.017

Cited by 36 publications

(33 citation statements)

References 31 publications

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“…[9] In our study, while TAC levels in liver tissues were found to be higher, TOS and OSI levels were found to be lower in treatment groups. A similar trend was found in the kidneys, but was not statistically significant.…”

supporting

confidence: 41%

“…Additionally, ratios of VEGF/Flt-1 in tissue and serum were calculated. A semiquantitative scoring system was used for the evaluation of histopathological findings which was used in our previous study [9] (Table 1).…”

Section: Experimental Designmentioning

confidence: 99%

“…[20] Moreover, the beneficial effects of sildenafil have been shown in the balance of oxidation and antioxidation via decreasing oxidative and nitrosative stress in inflammatory events. [9,23,[30][31][32][33][34] However, there is no study in the literature focusing on the effects of sildenafil in remote organ injury induced by severe burn except our previous study focusing on acute lung injury. [9] The purpose of the present study was to evaluate the effects of different dosages of sildenafil in distant organs, such as liver and kidneys, due to severe scald burn injury in rats.…”

Section: Introductionmentioning

confidence: 98%

“…[17,[19][20][21][22][23][24] Effects of different agents on oxidative damage due to severe burn injury were evaluated in remote organs such as the lung, liver, gut and kidney in previous studies. [4,9,[25][26][27][28] Sildenafil is known as a selective and potent inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase-5 (PDE-5). PDE-5 catalyzes the hydrolysis of cGMP.…”

Section: Introductionmentioning

confidence: 99%

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The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study

Gökakın

Atabey

Deveci

et al. 2014

Ulus Travma Acil Cerrahi Derg

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supporting

confidence: 41%

Section: Experimental Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study

Gökakın

Atabey

Deveci

et al. 2014

Ulus Travma Acil Cerrahi Derg

Self Cite

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“…However, there is no data about effect of sildenafil on MDA or lucigenin levels of stressed animals. Several studies have demonstrated the ameliorating effect of sildenafil on inflammatory processes and in I/ R models [30,42,45,[46][47][48][49][50][51][52]. In recent studies, chronic swimming exercise has been shown to block the MDA increase in oxidative stress and electric foot shock stress models [40,53].…”

Section: Discussionmentioning

confidence: 99%

Protective effect of exercise and sildenafil on acute stress and cognitive function

Özbeyli¹,

Gokalp²,

Koral³

et al. 2015

Physiology & Behavior

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Potential protective effect of 3,3′-methylenebis(1-ethyl-4-hydroxyquinolin-2(1H)-one) against bleomycin-induced lung injury in male albino rat via modulation of Nrf2 pathway: biochemical, histological, and immunohistochemical study

Hafez

Saber

Aziz

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

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Acute lung injury is a serious condition accounting for the majority of acute respiratory failure. Bleomycin (BLM) is an antibiotic that was first described as a chemotherapeutic agent. 3,3′-methylenebis(1-ethyl-4-hydroxyquinolin-2(1H)-one) was reported to have anti-inflammatory, anti-apoptotic, and anti-oxidative properties. The current work aimed to assess the possible protective effects and the mechanism of protection of 3,3′-methylenebis-(1-ethyl-4-hydroxyquinolin-2(1H)-one) on BLM-induced lung injury in addition to the effect and underlying mechanisms of nuclear factor-erythroid-related factor 2 pathway against this injury. Rats were equally divided into four groups: control group, BLM group, 1-ethyl-4-hydroxyquinolin-2(1H)-one-treated group, and BLM with 1-ethyl-4-hydroxyquinolin-2(1H)-one-treated group. At the end of the work, the blood samples were proceeded for biochemical study. Lung specimens were obtained for biochemical, histological, and immunohistochemical study. The results exhibited a significant increase in both malondialdehyde and tumor necrotic factor-α with a significant decrease in glutathione, superoxide dismutase, IL 10, surfactant protein A, and nuclear factor erythroid 2-related factor 2 in BLM group. The lung histological results showed various morphological changes in the form of disturbed architecture, inflammatory cell infiltration, and intraluminal debris. This group also displayed a significant increase in the mean surface area fraction of anti-cleaved caspase 3, while group IV exhibited amelioration in the previously mentioned parameters and histological alternations that were induced by BLM. It could be concluded that 3,3′-methylenebis(1-ethyl-4-hydroxyquinolin-2(1H)-one) has anti-oxidative, anti-inflammatory, and anti-apoptotic protective effects against BLM-induced lung injury.

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The protective effects of sildenafil in acute lung injury in a rat model of severe scald burn: A biochemical and histopathological study

Cited by 36 publications

References 31 publications

The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study

The effects of Sildenafil in liver and kidney injury in a rat model of severe scald burn: A biochemical and histopathological study

Protective effect of exercise and sildenafil on acute stress and cognitive function

Potential protective effect of 3,3′-methylenebis(1-ethyl-4-hydroxyquinolin-2(1H)-one) against bleomycin-induced lung injury in male albino rat via modulation of Nrf2 pathway: biochemical, histological, and immunohistochemical study

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