2005
DOI: 10.1055/s-2005-864135
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The Protective Effects of Rutaecarpine on Gastric Mucosa Injury in Rats

Abstract: Previous investigations have shown that calcitonin gene-related peptide (CGRP) protects gastric mucosa against injury induced by acetylsalicylic acid (ASA) and that rutaecarpine activates vanilloid receptors to evoke CGRP release. In the present study, we examined the protective effects of rutaecarpine on gastric mucosa injury, and explored whether the protective effects of rutaecarpine are related to stimulation of endogenous CGRP release via activating vanilloid receptors in rats. In an ASA-induced ulceratio… Show more

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Cited by 55 publications
(33 citation statements)
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References 15 publications
(19 reference statements)
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“…Traditional methods for chemical ulcer induction focus mainly on oral gavage of the ulcer causing agent [17,18]. While successful at producing an ulcer, the ulcer can only be viewed endoscopically in the intact stomach [19,20]. In addition, ulceration would occur across the entire stomach tissue making the direct comparison of ulcerated and healthy tissue difficult.…”
Section: Methods Of Chemical Ulcer Inductionmentioning
confidence: 99%
“…Traditional methods for chemical ulcer induction focus mainly on oral gavage of the ulcer causing agent [17,18]. While successful at producing an ulcer, the ulcer can only be viewed endoscopically in the intact stomach [19,20]. In addition, ulceration would occur across the entire stomach tissue making the direct comparison of ulcerated and healthy tissue difficult.…”
Section: Methods Of Chemical Ulcer Inductionmentioning
confidence: 99%
“…Evodiamine also inhibits gastric emptying and gastrointestinal transit [18]. Several studies demonstrated that rutaecarpine could inhibit platelet aggregation [16,19], modulate drug metabolizing enzymes [20], and protect gastric mucosa injury [21]. Therefore, in this study, the protoberberine alkaloids of coptisine, palmatine, and berberine in C. rhizoma and indolequinoline alkaloids of evodiamine and rutaecarpine in E. fructus were selected as bioavailability markers to determine and control the quality of Zuojin pill extract.…”
Section: Introductionmentioning
confidence: 99%
“…Rutaecarpine possesses a number of biological properties, including anti-hypertension, anti-thrombotic, anticancer and anti-inflammatory activities, particularly on relaxing vascular smooth muscle (12,13). Previous studies have revealed that the multiple pharmacological effects elicited by rutaecarpine are driven by the increase in endogenous calcitonin gene-related LU YAN 1 , QING-FU LI 1 , YAN-TING RONG 1 , YONG-HENG CHEN 2 , ZHAO-HONG HUANG 1 , ZHI-ZHI WANG 1 and JIE PENG peptide (CGRP) release following the activation of vanilloid receptor subtype 1 (VR1) (11,14). VR1, also known as the capsaicin receptor, is primarily expressed in sensory nerves.…”
Section: Introductionmentioning
confidence: 99%
“…1) is a quinazolinocarboline alkaloid isolated from Wu-Chu-Yu, the dried fruit of Evodia rutaecarpa Bentham (Rutaceae), a Chinese herbal drug (11). Rutaecarpine possesses a number of biological properties, including anti-hypertension, anti-thrombotic, anticancer and anti-inflammatory activities, particularly on relaxing vascular smooth muscle (12,13).…”
Section: Introductionmentioning
confidence: 99%