The protective effects of myricetin against acute liver failure via inhibiting inflammation and regulating oxidative stress via Nrf2 signaling

Abstract

This study aimed to investigate the protective effects and mechanisms of myricetin on acute liver failure in mice induced by lipopolysaccharide (LPS)/D-galactosamine (D-Gal). Our results showed myricetin (25, 50 and 100 mg/kg) pretreatment significantly improved the pathological changes of liver tissues, decreased serum ALT and AST (p < 0.001) induced by LPS/D-GalN. Moreover, MDA and MPO levels were reduced (p < 0.001), CAT and SOD activities were increased (p < 0.001) with myricetin (50 and 100 mg/kg) pretreatment. Likewise, inflammatory cytokines TNF-α and IL-6 mRNA in liver tissues were markedly decreased (p < 0.001) by myricetin.Besides, Nrf2 protein expression was drastically elevated (p < 0.001) by myricetin (25, 50 and 100 mg/kg). All these findings imply that myricetin may protect against acute liver failure by suppressing inflammation and regulating oxidative stress via Nrf2 signaling, and that it may be a possible strategy to avoid liver damage.

The Supplementation of Sechium edule var. nigrum spinosum (Chayote) Promotes Nrf2-Mediated Antioxidant Protection in Older Adults with Metabolic Syndrome

“…Finally, it is worth mentioning that, as explained in detail in a previous study, practically all the secondary metabolites existing in Sechium edule modulate the expression of Nrf2 mRNA; for example, cucurbitacins, naringenin, and caffeic and ferulic acids have been related to an increase in Nrf2 gene expression and inhibition of NFκB-mediated signaling [64][65][66][67]. Apigenin, myricetin, and gallic acid improve translocation and/or nuclear accumulation [68][69][70]. Quercetin only temporarily stimulates its expression [71].…”

Unveiling myricetin's pharmacological potency: A comprehensive exploration of the molecular pathways with special focus on PI3K/AKT and Nrf2 signaling

“…significantly elevated the protein expression of Nrf2. [77] Myricetin exhibited protective effects against fulminant hepatitis induced by lipopolysaccharide and D-galactosamine. This protection involved the inhibition of hepatic apoptosis, inflammation, and oxidative stress.…”

“…Myricetin (0, 5, 10, 15, 20 μM) Nucleus pulposus cells (NPCs) Activated Nrf2 and attenuated inflammatory factors production [76] 14. Acute liver failure Myricetin (25, 50 and 100 mg/kg) Male BALB/c mice Decreased ALT and AST, increased CAT and SOD activities, TNF-α and IL-6 via elevated Nrf2 pathway [77] glycogen synthase kinase (GSK) 3β is pivotal in the process of blood clot formation under conditions of elevated shear stress. [83] Furthermore, myricetin demonstrated significant inhibition of the activation of the PI3K/AKT/GSK3β pathway in platelets stimulated by collagen at concentrations of 10, 20 μM, thereby serving as a potent antithrombotic agent.…”

Effects of the nutraceutical myricetin on liver health: a systematic review

“…In the study by Wang et al (2023), myricetin demonstrated a protective effect against acute liver injury induced by LPS/D-GalN (lipopolysaccharide/D-galactosamine) in mice.…”