The protective effects of melatonin on survival, immune response, digestive enzymes activities and intestinal microbiota diversity in Chinese mitten crab (Eriocheir sinensis) exposed to glyphosate

Song, Yameng; Song, Xiaozhe; Wu, Mengyao; Pang, Yangyang; Shi, Aoya; Shi, Xingliang; Niu, Chao; Cheng, Yongxu; Yang, Xiaozhen

doi:10.1016/j.cbpc.2020.108845

Cited by 14 publications

(4 citation statements)

References 52 publications

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“…42–46 Similarly, the herbicide was able to reduce the survival rate of Chinese crabs by reducing the diversity of the gut microbiota, as well as decreasing enzyme activity in the animal's intestinal tract. 47,48…”

Section: Resultsmentioning

confidence: 99%

“…[42][43][44][45][46] Similarly, the herbicide was able to reduce the survival rate of Chinese crabs by reducing the diversity of the gut microbiota, as well as decreasing enzyme activity in the animal's intestinal tract. 47,48 Overall, the data indicate that ingestion of the GLY herbicide and its formulations is able to trigger a gut dysbiosis in different experimental models. In this context the studies reported diverse findings, with an increase of bacteria from Bacteroidetes, 18,[48][49][50][51] Proteobacteria, 16,48,52 Tenericutes, 18,49 Actinobacteria, 49,53 Desulfobacteria, 16 Spirochaetes, 49 Fusobacteria, 12 Deferribacteres 51 and Firmicutes phyla.…”

Section: Effect Of Gly and Its Formulations On The Intestinal Microbiotamentioning

confidence: 93%

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Effects of glyphosate exposure on intestinal microbiota, metabolism and microstructure: a systematic review

Ignácio,

Guerra,

de Souza-Silva

et al. 2024

Food Funct.

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Section: Resultsmentioning

confidence: 99%

Section: Effect Of Gly and Its Formulations On The Intestinal Microbiotamentioning

confidence: 93%

Effects of glyphosate exposure on intestinal microbiota, metabolism and microstructure: a systematic review

Ignácio,

Guerra,

de Souza-Silva

et al. 2024

Food Funct.

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“…In this study, lower nocturnal percentage of Gram-positive (24%) and Gram-negative cocci (38%) as well as Gram-positive (42%) and Gram-negative (44%) Bacillus are observed relative to their respective diurnal values. In glyphosatetreated Chinese mitten crab (Eriocheir sinensis), the supply of MEL (80 mg/kg food) as a supplement to the standard feed for 14 days significantly increases the relative abundance and Shannon index of Proteobacteria and Bacteroidete along with an enhanced activity of amylase, lipase, and trypsin in the gut (Song et al, 2020). Further, in zebra fish (D. rerio), 1 µM MEL administration in filtered tank water for 14 days improves metabolism and normal gut microbial homeostasis, and restores neurotransmitter release (Zhang et al, 2021).…”

Section: Impact Of Melatonin On Microbiota In Fish Gutmentioning

confidence: 99%

Melatonin as a Multipotent Component of Fish Feed: Basic Information for Its Potential Application in Aquaculture

2021

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In vertebrates, melatonin (N-acetyl-5-methoxy-tryptamine, MEL) is synthesized from L-tryptophan (L-Trp), primarily in the pineal gland and additionally in several non-pineal tissues, including enterochromaffin cells of the gastrointestinal tract. The biosynthesis of MEL in the pinealocytes exhibits a daily rhythm with a nocturnal peak in synchronization with the dark phase of an environment. However, the temporal pattern of the gut melatoninergic system in fish is known to be synchronized with one or more non-photic external cue(s), of which most notable include the components of food and feeding time in a daily cycle. Experimental findings on the use of L-Trp (5-fold to −8-fold higher with respect to standard) as a fish food supplement suggest that it has a stimulatory influence on gut MEL synthesis that ultimately leads to elevated levels of plasma MEL. Several studies employing MEL as a fish feed additive report variable responses in relation to the physiological functions of the fish and its doses of application and modes of exposure. Oral administration of MEL (validated dose in general: 200 mg/kg fish food) causes an increase in gut MEL concentrations, food intake capacity, and micronutrient selection ability of fish, as well as enhanced activity of antioxidative enzymes and/or reduced levels of biological stress markers like plasma cortisol and lactate. The application of MEL with the doses of 50 and 250 mg/kg fish food to balanced diet results in precious maturation of gonads, high live sperm rate, and good quality seeds in catfish. A few studies on different fish groups administered with MEL through tank water reveal a significant increase in the fecundity rate, percentage of fertilization, and the number of hatched embryos. MEL injection through intraperitoneal or intramuscular routes also elicits variable responses in fish. Several studies suggest a major protective role of endogenous MEL against gastric ulcer induced by pathogenic bacterial infection. Taken together, MEL seems to be a multipotent physiological candidate involved in the regulation of a variety of body functions ranging from the synchronization of vital activities with environmental variables to the timing of reproduction in a changing system, from the acceleration of body growth to the determination of a pattern of development, and from the reduction of oxidative stress to the protection against microbial infections. Because aquaculture aims at substantially improving the quality and quantity of available aquatic resources employing convenient, consistent, and commercially exploitable measures, we find the reasons to suggest that the use of MEL or its precursor L-Trp as a fish food supplement may open up a new vista of aquaculture and, hence, present this review with an attempt to present the basic information on this area of interest to justify the hypothesis.

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“…It was reported that 100 mg/kg of melatonin as a therapeutic agent decreased proinflammatory cytokine levels and the number of apoptotic neurons in Klebsiella pneumoniae-infected rats [12]. Recently, it is worth noting that melatonin can influence intestinal microbiota [15][16][17][18]. Melatonin supplements can reshape the composition of intestinal microbiota, resulting in the alleviation of weanling-induced stress [15].…”

Section: Introductionmentioning

confidence: 99%

Melatonin Is Neuroprotective in Escherichia coli Meningitis Depending on Intestinal Microbiota

Zhang

Shu

et al. 2022

IJMS

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Avian meningitis Escherichia coli (E. coli) can cause acute bacterial meningitis which threatens poultry health, causes great economic losses in the poultry industry, and has recently been speculated as a potential zoonotic pathogen. Melatonin can counteract bacterial meningitis-induced disruption of the blood–brain barrier (BBB), neuroinflammation, and reduce mortality. There are increasing data showing that melatonin’s beneficial effects on bacterial meningitis are associated with intestinal microbiota. In this study, our data showed that melatonin alleviated neurological symptoms, enhanced survival rate, protected the integrity of the BBB, reduced the bacterial load in various tissues and blood, and inhibited inflammation and neutrophil infiltration of brain tissue in an APEC TW-XM-meningitis mice model. The results of 16S rRNA showed that melatonin pretreatment significantly maintained the composition of intestinal microbiota in APEC-meningitis mice. The abundance and diversity of intestinal microbiota were disturbed in APEC TW-XM-meningitis mice, with a decreased ratio of Firmicutes to Bacteroides and an increased the abundance of Proteobacteria. Melatonin pretreatment could significantly improve the composition and abundance of harmful bacteria and alleviate the decreased abundance of beneficial bacteria. Importantly, melatonin failed to affect the meningitis neurologic symptoms caused by APEC TW-XM infection in antibiotic-pretreated mice. In conclusion, the results suggest that melatonin can effectively prevent meningitis induced by APEC TW-XM infection in mice, depending on the intestinal microbiota. This finding is helpful to further explore the specific target mechanism of melatonin-mediated intestinal microbiota in the prevention of and protection against Escherichia coli meningitis.

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The protective effects of melatonin on survival, immune response, digestive enzymes activities and intestinal microbiota diversity in Chinese mitten crab (Eriocheir sinensis) exposed to glyphosate

Cited by 14 publications

References 52 publications

Effects of glyphosate exposure on intestinal microbiota, metabolism and microstructure: a systematic review

Effects of glyphosate exposure on intestinal microbiota, metabolism and microstructure: a systematic review

Melatonin as a Multipotent Component of Fish Feed: Basic Information for Its Potential Application in Aquaculture

Melatonin Is Neuroprotective in Escherichia coli Meningitis Depending on Intestinal Microbiota

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