The protective effects of melatonin against water avoidance stress-induced mast cell degranulation in dermis

EXPRESSION OF CONCERN: The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double‐blinded, placebo‐controlled trial

“…Our results are consistent with another study showed that consumption of 3 mg/d melatonin for 4 weeks improved the clinical status in children suffering from AD, but did not affect serum total IgE levels. 12 In an experimental rat model, Cikler et al 24 Melatonin and its precursor l-tryptophan have been suggested as parameters reducing total IgE and IL-4 concentrations. 19 Melatonin suppresses IL-2 production and promotes Treg activity likely via its nuclear specific high-affinity binding sites on Th1 and Th2 and its membrane receptor (MT1).…”

Laughter elevates the levels of breast-milk melatonin

“…On the other hand, melatonin was involved in stress responses [12]. Melatonin also reduced stress-induced mast cell degranulation in dermis in rats [13]. It is tempting to speculate that relaxation by laugher may elevate melatonin levels, which in turn may reduce allergic responses by inhibiting mast cell responses.…”

Neuroendocrine and circadian aspects (melatonin and β‐endorphin) of atopic dermatitis in the child

“…Once again, the Th1–Th2 balance may be crucial to the interpretation of quantitative differences in cytokine expression in response to environmental stimuli‐like stress, which may overlap with those altered by physical pollutants and toxicants (53). Reinforcing the possible clinical utility of melatonin, in one experimental model of stress‐induced skin disorders, chronic melatonin treatment reduced the infiltration and activation of mast cells in the dermis (54). The reduced daytime circulating levels of melatonin in AD, as shown by the data presented in our paper, may reflect the reduced production of melatonin of extrapineal (immunological) origin.…”