The protective effects of melatonin on blood cell counts of rectal cancer patients following radio-chemotherapy: a randomized controlled trial

Habibi, Nasim Kouhi; Monfared, Ali Shabestani; Gorji, Kourosh Ebrahimnejad; Karimi, Masoumeh; Moghadamnia, Ali Akbar; Tourani, Mehdi; Borzoueisileh, Sajad; Niksirat, Fatemeh

doi:10.1007/s12094-018-1977-2

Cited by 14 publications

(9 citation statements)

References 39 publications

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“…Treating breast cancer patients with a MLT-emulsion resulted in a lower dermatitis incidence ( 96 ). Post-radiotherapy MLT treatment is proposed to mitigate long-term radiation effects ( 417 ). Others did not observe synergistic effects with radiotherapy, although only upon comparison with controls from other studies ( 97 ).…”

Section: Protecting Normal Tissue During Radiotherapymentioning

confidence: 99%

Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio

2021

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To meet the anabolic demands of the proliferative potential of tumor cells, malignant cells tend to rewire their metabolic pathways. Although different types of malignant cells share this phenomenon, there is a large intracellular variability how these metabolic patterns are altered. Fortunately, differences in metabolic patterns between normal tissue and malignant cells can be exploited to increase the therapeutic ratio. Modulation of cellular metabolism to improve treatment outcome is an emerging field proposing a variety of promising strategies in primary tumor and metastatic lesion treatment. These strategies, capable of either sensitizing or protecting tissues, target either tumor or normal tissue and are often focused on modulating of tissue oxygenation, hypoxia-inducible factor (HIF) stabilization, glucose metabolism, mitochondrial function and the redox balance. Several compounds or therapies are still in under (pre-)clinical development, while others are already used in clinical practice. Here, we describe different strategies from bench to bedside to optimize the therapeutic ratio through modulation of the cellular metabolism. This review gives an overview of the current state on development and the mechanism of action of modulators affecting cellular metabolism with the aim to improve the radiotherapy response on tumors or to protect the normal tissue and therefore contribute to an improved therapeutic ratio.

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Section: Protecting Normal Tissue During Radiotherapymentioning

confidence: 99%

Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio

2021

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“…104 Melatonin could prevent or minimize the unfavorable effects of radiotherapy on blood cell count and has potential protective effects on bone marrow. [105][106][107]…”

Section: Phytotherapeutics With Immunostimulant Activitymentioning

confidence: 99%

Integrative Treatment of Lung Cancer Patients: Observational Study of 57 Cases

Anelli¹,

Nardo²,

Bonucci³

2021

ASJO

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Introduction A retrospective clinical study was performed to identify the characteristics of patients with lung cancer treated with integrative cancer treatment in addition to conventional medicine. Materials and Methods We reviewed medical records for lung cancer patients who visited a single integrative setting in Rome, Italy. A total of 57 patients were included, and the majority had advanced-stage cancer. All of them underwent integrative therapy with nutrition and phytotherapy indications. The diet was designed to reduce most of possible factors promoting cancer proliferation, inflammation, and obesity. Foods with anti-inflammatory, prebiotic, antioxidant, and anticancer properties had been chosen. Herbal supplements with known effects on lung cancer were prescribed. In particular, astragal, apigenine, fucosterol, polydatin, epigallocatechin gallate, cannabis, curcumin, and inositol were used. Furthermore, medical mushrooms and other substances were used to improve the immune system and to reduce chemotherapy side effects. Five key parameters have been evaluated for 2 years starting at the first surgery: nutritional status, immune status, discontinuation of therapy, quality of life, and prognosis of the disease. Results A relevant improvement in parameters relative to nutritional status, immune status, and quality of life has been observed after integrative therapy compared with the same parameters at the first medical visit before starting such approach. Conclusion The results suggest that integrative therapy may have benefits in patients with lung cancer. Even though there are limitations, the study suggests that integrative therapy could improve nutritional status and quality of life, with possible positive effect on overall survival.

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“…Melatonin (N-acetyl-5-methoxytryptamine), an indole compound synthesized by the pineal gland and many other tissues is involved in various essential physiological processes (13)(14)(15)(16). The protective effect of melatonin against radiationinduced DNA and chromosome damage has been demonstrated in both human (17)(18)(19)(20) and experimental animal studies (21)(22)(23)(24). Melatonin prevents the death of animals given what would normally be a lethal dose of ionizing radiation (12).…”

Section: Electronsmentioning

confidence: 99%

Molecular mechanisms of melatonin’s protection against high-LET radiation: implications for space travel

Liu

Reíter

2020

Melatonin Res.

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During a deep space mission, the central nervous system (CNS) and other organs are exposed to galactic cosmic rays and solar particle events. Health risks associated with various organs and systems are important issues in a long-term spaceflight. Potential CNS damage during a space mission could alter cognitive functions which might impact performance and individual’s health. The neuronal injury originating from exposure to 56Fe particle irradiation involves the elevated oxidative stress which can be inhibited by melatonin pretreatment. Melatonin exerts potent neuroprotective effects against carbon ion-induced mitochondrial dysfunction and apoptosis in the mouse brain. A significant increase in the count of immature neurons and proliferating cells was detected in the mice under 56Fe particle irradiation cotreated with the melatonin metabolite, AFMK. Melatonin treatment also significantly reduced the carbon ion-induced apoptotic cells and elevated oxidative stress in the mouse testis. The results suggest that melatonin treatment is a potential strategy to protect against space radiation hazards. Spaceflight-induced molecular, cellular, and physiologic changes lead to alterations across many organs and systems. Epigenetic, gene expression, inflammatory, and metabolic responses to spaceflight should be examined and means to safe-guard against these changes in upcoming missions. Precision medicine will be crucial for assessing and augmenting efficacy of melatonin or other medications in astronauts. In addition, enhancing radio-resistance of humans is a novel strategy for a long-term space mission. Further investigations with a combination of melatonin and other novel technologies are warranted to better alleviate HZE particle irradiation-induced damage to astronauts on long-term space exploration missions.

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The protective effects of melatonin on blood cell counts of rectal cancer patients following radio-chemotherapy: a randomized controlled trial

Cited by 14 publications

References 39 publications

Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio

Metabolic Rewiring in Radiation Oncology Toward Improving the Therapeutic Ratio

Integrative Treatment of Lung Cancer Patients: Observational Study of 57 Cases

Molecular mechanisms of melatonin’s protection against high-LET radiation: implications for space travel

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