The protective effects of <i>Sauropus spatulifolius</i> on acute lung injury induced by lipopolysaccharide

Wei, Xiangdong; Li, Yanmei; Li, Meng; Min, Chunyan; Lü, Hui; Li, Qi-Run; Yuan, Jie; Chen, Chen; Li, Heran; Zhang, Jian

doi:10.1002/jsfa.8964

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…Twenty-four hours after PBS or LPS treatment, the animals were euthanized by CO 2 gas. The TRX and Dex dosages used in this study were based on previously published literature [28–33].…”

Section: Methodsmentioning

confidence: 99%

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Combining an in silico approach with an animal experiment to investigate the protective effect of troxerutin for treating acute lung injury

Liu

et al. 2019

BMC Complement Altern Med

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Background Troxerutin (TRX), a naturally occurring flavonoid in various fruits, has been reported to exhibit numerous pharmacological and biological activities in vitro and in vivo. However, the molecular mechanisms underlying TRX as a treatment for disease are poorly understood. Methods Using pharmacophore mapping and inverse docking, a set of potential TRX target proteins that have been associated with multiple forms of diseases was obtained. Bioinformatic analyses were performed using the Enrichr and STRING servers to analyse the related biological processes and protein-protein networks. Furthermore, we investigated the potential protective effect of TRX against lipopolysaccharide-induced acute lung injury (ALI) using a mouse model. Morphological changes in the lungs were assessed using haematoxylin and eosin staining. Inflammatory cytokines, tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6 and IL-10 were investigated using ELISA. Activation of MAPK and NF-κB was detected using western blotting. Results Our network pharmacology analysis revealed the existence of multiple TRX-related chemical-target interactions and the related biological processes. We found that pretreatment with TRX protected against histological changes and obviously regulated the inflammatory cell counts and inflammatory cytokine levels in bronchoalveolar lavage fluid. Based on bioinformatic and western blot analyses, TRX may exert a protective effect against ALI by inhibiting MAPK and NF-κB signalling. Conclusions TRX can ameliorate pulmonary injury by inhibiting the MAPK and NF-κB signalling pathways and has a potential protective effect against ALI. This study may be helpful for understanding the mechanisms underlying TRX action and for discovering new drugs from plants for the treatment of ALI. Electronic supplementary material The online version of this article (10.1186/s12906-019-2515-7) contains supplementary material, which is available to authorized users.

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“…Twenty-four hours after PBS or LPS treatment, the animals were euthanized by CO 2 gas. The TRX and Dex dosages used in this study were based on previously published literature [28–33].…”

Section: Methodsmentioning

confidence: 99%

“…Subsequently, the lung tissues were subsequently incubated at 90 °C for 24 h and weighed to obtain the dry weight ( n = 5–7 in each group). Then, the lung W/D ratio was calculated [32, 33].…”

Section: Methodsmentioning

confidence: 99%

Combining an in silico approach with an animal experiment to investigate the protective effect of troxerutin for treating acute lung injury

Liu

et al. 2019

BMC Complement Altern Med

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“…Crystallographic Data of 3. 3 . A total of 11 850 reflections were measured in the range of 7.828°≤ 2θ ≤ 144.646°, containing 5486 unique reflections (R int = 0.0332, R sigma = 0.0416), which were used in all calculations.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…spatulifolius is used widely as a vegetable ingredient in cooking and as a herbal medicine for cough, asthma, bronchitis, and other conditions . Moreover, a decoction of the leaves of S. spatulifoliu s is consumed as a natural herbal tea to relieve pneumonia . However, only a few studies have focused on the secondary metabolites of S .…”

mentioning

confidence: 99%

“…2 Moreover, a decoction of the leaves of S. spatulifolius is consumed as a natural herbal tea to relieve pneumonia. 3 However, only a few studies have focused on the secondary metabolites of S. spatulifolius, revealing it to contain mainly alkaloids, 4 lignans, 3 and hexose derivatives. 5 Stimulated by its wide applications in folk medicine, we implemented a systematic phytochemical investigation of the leaves of S. spatulifolius.…”

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confidence: 99%

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Diterpenoids from Sauropus spatulifolius Leaves with Antimicrobial Activities

Cui

Han

et al. 2022

J. Nat. Prod.

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As a plant used in both food and medicine, Sauropus spatulifolius is consumed widely as a natural herbal tea, food source, and Chinese medicine. Inspired by its extensive applications, we conducted a systematic phytochemical study of the leaves of S. spatulifolius. Thirteen new diterpenoids, sauspatulifols A–M (1–13), including four ent-cleistanthane-type diterpenoids (1–4), eight 15,16-di-nor-ent-cleistanthane-type diterpenoids (5–12), and one 17-nor-ent-pimarane-type diterpenoid (13) as well as one known diterpenoid, cleistanthol (14), were isolated. All of these diterpenoids feature a 2α,3α-dihydroxy unit within the A ring, and their structures were elucidated by spectroscopic data analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction analysis. Compound 14 displayed moderate inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Shigella flexneri with the same minimum inhibitory concentration value of 12 μg/mL as well as activity against vesicular stomatitis virus and influenza A virus.

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Isolation and characterization of secondary metabolites from the leaves of Sauropus spatulifolius Beille and their potential biological assays

Cui

Zhu

et al. 2022

Fitoterapia

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The protective effects of Sauropus spatulifolius on acute lung injury induced by lipopolysaccharide

Abstract: Long-Li-Ye could be used as a natural antioxidant for food production and functional food or dietary supplementation for people with ALI. © 2018 Society of Chemical Industry.

Cited by 7 publications

References 19 publications

Combining an in silico approach with an animal experiment to investigate the protective effect of troxerutin for treating acute lung injury

Combining an in silico approach with an animal experiment to investigate the protective effect of troxerutin for treating acute lung injury

Diterpenoids from Sauropus spatulifolius Leaves with Antimicrobial Activities

Isolation and characterization of secondary metabolites from the leaves of Sauropus spatulifolius Beille and their potential biological assays

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