The protective effects of glutamine on radiation-induced diarrhea

Küçüktülü, Eda; Güner, Ali; Kahraman, İzzettin; Topbaş, Murat; Kucuktulu, Uzer

doi:10.1007/s00520-012-1627-0

Cited by 25 publications

(16 citation statements)

References 27 publications

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“…In another study, the protective effect of glutamine in radiation-induced diarrhea was evaluated 5 . Patients receiving glutamine (15 g/3 times a day) were compared with patients receiving placebo.…”

Section: Glutaminementioning

confidence: 99%

Use of Functional Foods and Oral Supplements as Adjuvants in Cancer Treatment

Serna-Thomé

Castro-Eguiluz

Fuchs-Tarlovsky

et al. 2018

RIC

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In cancer patients treated with radiotherapy to the abdominopelvic region, dietary modifications and the use of functional foods (fortified food with added ingredients to provide specific health improving benefits, such as antioxidants, omega-3 fatty acids, and glutamine), may contribute to the improvement of the toxic effects of treatment, including nausea, diarrhea, and constipation, among others. With the aim of analyzing which coadjuvant foods benefit these patients, scientific evidence was gathered by a group of experts. For these patients, the authors recommend a diet that includes sufficient foods rich in antioxidants and polyphenols instead of supplements. Docosahexaenoic and eicosapentaenoic acids have proven useful for the management of anorexia/cachexia in pancreatic cancer patients. Probiotics composed of Lactobacillus spp. and Bifidobacterium spp. are regarded as safe even in patients with neutropenia and have been proven to decrease gastrointestinal symptoms. Several factors should be considered before probiotic supplementation, these include the stage of the disease, radiation dose, and symptomatology of each patient. There is no demonstrated clear benefit to the use of glutamine, so it is not recommended due to its high cost.

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Section: Glutaminementioning

confidence: 99%

Use of Functional Foods and Oral Supplements as Adjuvants in Cancer Treatment

Serna-Thomé

Castro-Eguiluz

Fuchs-Tarlovsky

et al. 2018

RIC

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“…The L/M ratio, which decreased mildly before the operation owing to intestinal lesion, plummeted in the postoperative 14 days after removing or bypassing the intestinal lesion. Recent studies have conflicting results over the effects of oral glutamine on patients with radiation enteritis, [18][19][20] with one of the reasons being differences between patient conditions as well as doses and routes of glutamine supplementation. It is well established that glutamine may enhance the functions of immune cells (eg, lymphocytes and macrophages) as the main energy substrate and nitrogen source and that it is critical for lymphocyte differentiation.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Alanyl‐Glutamine–Supplemented Parenteral Nutrition in Chronic Radiation Enteritis Patients With Surgical Intestinal Obstruction

et al. 2015

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“…This substance is also known as the chemical messenger, for its ability to interact with neurons and allow cell communication, as well as an energy source in oxidation processes of cancer cells [5].…”

Section: Glutamic Acidmentioning

confidence: 99%

Importance of the Nutrition with Antioxidants in the Treatment of Cancer and Others Damages

Trinidad¹,

Flores²,

Palafox³

et al. 2019

Antioxidants

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The antioxidants are molecules capable of retarding or anticipating the oxidation of other molecules. Epidemiological results have shown that the persons who consume a rich diet of fruits and vegetables present a minor risk of suffering different types of cancer, cardiovascular and neurological diseases, and a minor mortality than the persons who consume few fruits and vegetables. Others studies suggests that the vitamins are antioxidants like can to decrease hurt oxidative in the physiopathology of many chronic diseases and cancer. Nevertheless, evidence of new studies in mice shows that vitamins can promote the growth of tumors and metastasis and the expression of the gene p53. Current studies indicate that patients with cancer and people who have a major risk of cancer will have to avoid taking complements of antioxidants, due to the fact that it was thought that antioxidants might protect cells against cancer since they neutralize reactive oxygen species (ROS) that can damage the DNA, but in studies of animals, it has been indicated that the presence of major concentrations of antirust exogenous prevents the type of hurt of free radical that has been associated with the formation of cancer.

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The protective effects of glutamine on radiation-induced diarrhea

Abstract: Glutamine may have protective effect on radiation-induced severe diarrhea.

Cited by 25 publications

References 27 publications

Use of Functional Foods and Oral Supplements as Adjuvants in Cancer Treatment

Use of Functional Foods and Oral Supplements as Adjuvants in Cancer Treatment

Perioperative Alanyl‐Glutamine–Supplemented Parenteral Nutrition in Chronic Radiation Enteritis Patients With Surgical Intestinal Obstruction

Importance of the Nutrition with Antioxidants in the Treatment of Cancer and Others Damages

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