The protective effects of ghrelin and leptin against stress-induced gastric ulcer in rats

Khalefa, Abeer A.; Abd-Alaleem, Dalia I.; Attiaa, Kamelia I.

doi:10.1016/j.ajg.2010.04.005

Cited by 11 publications

(11 citation statements)

References 34 publications

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“…The stomach was cut open through the greater curvature and was rinsed with ice‐cold saline, to clean any blood clots and gastric content. According to the previous study (Khalefa, Abd‐Alaleem, & Attiaa, ; Zhu et al, ), the severity of mucosal lesions was assessed by a magnifier and ulcers were scored by a blind observer using the experimental protocols as follows: 0 = no damage; 1 = erosions ≤ 1 mm (including blood in the lumen); 2 = 1 mm < erosions ≤ 2 mm; 3 = 2 mm < erosions ≤ 3 mm; 4 = 3 mm < erosions ≤ 4 mm; 5 = erosions > 4 mm, and the total scores were added as the ulcer index (UI). The ulcer inhibition rate was calculated according to the formula: (UI model − UI treated)/UI model × 100%.…”

Section: Methodsmentioning

confidence: 99%

“…The stomach was cut open through the greater curvature and was rinsed with ice-cold saline, to clean any blood clots and gastric content. According to the previous study (Khalefa, Abd-Alaleem, & Attiaa, 2010;Zhu et al, 2014), the severity of mucosal lesions was assessed by a magnifier and ulcers were scored by a blind observer using the experimental protocols as follows: 0 5 no damage; 1 5 erosions 1 mm (including blood in the lumen); 2 5 1 mm< erosions 2 mm; 3 5 2 mm< erosions 3 mm;…”

Section: Estimation Of Wrs-induced Gastric Injurymentioning

confidence: 99%

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Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats

et al. 2018

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In this study, ultrasound‐assisted extraction method (UAE) was developed to obtain the protease‐rich extract from sheep abomasum (SAE). UAE parameters were first optimized using response surface methodology. Ultrasonic time of 18 min, ultrasonic power of 260 W, and a liquid/solid ratio of 22 mL/g resulted in the highest proteolytic activity and yield of the SAE (4,951.3 U/g, 14.3%, respectively). Then we investigated SAE's gastroprotective effect against gastric ulcers induced by water immersion‐restraint stress in rats. After 7 days of intragastric administration of the SAE (0.2 g/kg/day), the ulcer index (2.71 ± 0.97; p < .05) decreased significantly compared with that in the model group, and the ulcer inhibition ratio was 66.5%. In addition, the response to stress was significantly attenuated by balancing the levels of norepinephrine, 5‐hydroxytryptamine, and dopamine in brain regions. Practical applications Sheep abomasum is the main waste of the sheep meat industry. Converting those wastes to value‐added products would be beneficial for both environment and economy. Results of this study presented that UAE resulted in a higher proteolytic activity and yield of SAE with a shorter extraction time than the conventional extraction method. The SAE obtained in this study may be a promising agent for prophylaxis and treatment of stress‐induced ulcers.

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Section: Methodsmentioning

confidence: 99%

Section: Estimation Of Wrs-induced Gastric Injurymentioning

confidence: 99%

Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats

et al. 2018

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“…Ulcer severity [16] (the total ulcer surface area was measured by a transparent graph paper), ulcer score [16]; (gastric lesions were scored according to their severity between 1 and 6, as in Table 1, and ulcer index [16] (ulcer index = mean ulcer score of the similarly treated group Â percentage of ulcerated animals of the same group) were determined. Values were expressed as mean ± standard error of mean.…”

Section: Methodsmentioning

confidence: 99%

Possible protective effect of gum arabic on experimentally induced gastric ulcer in adult male albino rats

Helal¹,

Yousef²,

El-Naa³

2011

The Egyptian Journal of Histology

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“…Ulcer index = mean ulcer score of similarly treated group x percentage of unlcerated animals of the same group [22,23] II. Biochemical assays:…”

Section: Evaluation Of Fundic Mucosal Injurymentioning

confidence: 99%

Histological and Biochemical Study on the Estrogen Role in Indomethacin-induced Gastric Ulcer of Menopausal Rats

Mohamed

Ahmed

Shalaby

et al. 2019

Journal of Medical Histology

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Background: Estrogen is a principal female sex hormone that originally characterized by its importance in sexual growth and reproduction. Nevertheless, emergent evidence proposes clinical relationship between estrogen/ estrogen receptors and gastric diseases. This association is definitely under several investigated topics. Aim: The current study designed to explore exogenous estrogen effect on indomethacin-induced gastric ulcers in postmenopausal female rats. Matrial and methods: Twenty-four female rats (200 ± 20 gram BW) were allocated randomly into four groups; control, ulcer-induced, ranitidine-treated and (ranitidine&estradiol velerate) combined-treated group. Animal in all group except control subjected to ovariectomy to assimilate menopausal condition. At end of the experiment, the stomach fundus examined macroscopically to assess the ulcer severity and ulcer score in different groups. Histopatholgical and biochemical evaluation also were performed and all results were statistically analyzed. Results: Indomethacin-induced gastric ulcer in ovariectomized rats showed destroyed fundic mucosa and mucus layer, increase oxidative stress markers, inflammatory mediators and myeloperoxidase. Treatment with ranitidine attenuated the histological and biochemical changes but within limits. Better improvement was accomplished when ranitidine combined with estrogen. Conclusion: The postmenopausal women should be supplemented with estrogen not only to control menopausal symptoms but also to protect and maintain gastric mucosal integrity.

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The protective effects of ghrelin and leptin against stress-induced gastric ulcer in rats

Cited by 11 publications

References 34 publications

Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats

Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats

Possible protective effect of gum arabic on experimentally induced gastric ulcer in adult male albino rats

Histological and Biochemical Study on the Estrogen Role in Indomethacin-induced Gastric Ulcer of Menopausal Rats

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