The Protective Effects of Compound 21 and Valsartan in Isoproterenol-Induced Myocardial Injury in Rats

[Retracted] Effects of Valsartan on LN, FN, MDA, Renal Tissue Fibrosis, and Inflammatory Infiltration in DN Rats

“…Animal model preparation and set administration Reference [ 21 ]. Preparation of DN model rats: SD rats are anesthetized by intraperitoneal injection of 2.5% sodium pentobarbital solution at a dose of 45 mg/kg, the left kidney is surgically removed and fed for 1 week after suture, intraperitoneal injection of streptozotocin solution at a dose of 60 mg/kg, blood glucose is measured 72 hours later, and the results are higher than 16.7 mmol/L for at least 2 times.…”

Hypochlorous acid-activated two-photon fluorescent probe for evaluation of anticancer drug-induced cardiotoxicity and screening of antioxidant drugs

“…To summarise some of the findings: (1) the up-regulated MPO was not only the key factor in increasing HClO, but also one of the pivotal markers of tissue lesions; 37,38 (2) tumor necrosis factor (TNF-α) was a proinflammatory cytokine related to normal inflammatory and immune responses, and its expression was dependent on the up-regulation of reactive oxygen species. 39 We speculated that as a ROS, HClO was involved in the cardiotoxicity induced by anticancer drugs through the pathways illustrated in Fig.…”

Angiotensin II type 1 receptor blockade attenuates gefitinib-induced cardiac hypertrophy via adjusting angiotensin II-mediated oxidative stress and JNK/P38 MAPK pathway in a rat model

“…Valsartan was dissolved in saline by adding 0.1 M NaOH to obtain a clear solution and the PH was normalized using 0.1 M HCl ( Jiao et al, 2012 ). The dose of gefitinib ( Korashy et al, 2016 , Alhoshani et al, 2020 ), and valsartan ( Alhazzani et al, 2021 , Ulutas et al, 2021 ) were selected based on previous published articles.…”