The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities

Shen, Xiangchun; Tang, Yuping; Yang, Ruihui; Yu, Li; Tai-hui, Fang; Duan, Jin‐Ao

doi:10.1016/j.jep.2009.01.027

Cited by 127 publications

(77 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings were corroborated by histopathological observations of affected livers. As shown both here and in a previous study 25 , hydrazine can cause various hepatic histological changes, including multiple, extensive areas of portal inflammation, hepatocellular necrosis randomly distributed throughout the parenchyma, and increases in inflammatory cell infiltration. Results presented here show that MAKS can attenuate these histological changes and thus significantly suppresses hydrazine-induced liver injury.…”

Section: Discussionsupporting

confidence: 82%

“…A number of drugs, chemicals, and viruses re-portedly cause severe liver necrosis, which can be difficult to treat 3,4,21,25,27,28 . Thus it is highly important to identify compounds that could ameliorate liver damage and hepatic failure.…”

Section: Discussionmentioning

confidence: 99%

“…ALT and AST activities in serum were used as biochemical markers for early acute hepatic damage 5,25,26 . As shown in Table 2, these activities were significantly higher in hydrazine-treated rats than in the controls.…”

Section: Alt and Ast Activities In Serummentioning

confidence: 99%

“…The liver, the largest organ in the human body, plays a vital role in clearing diverse toxins and xenobiotics [25][26][27] . Partly because several kinds of free radicals are produced in the liver during their elimination, various deleterious agents can induce inflammation, fibrosis, necrosis, and eventually cirrhosis and functional deterioration of the organ 28 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Characterization of melanin extracted from apricot (Armeniaca sibirica) and its effect on hydrazine-induced rat hepatic injury

Li¹,

Li²,

Zhao³

2016

ScienceAsia

View full text Add to dashboard Cite

ABSTRACT:Melanin is a complex, highly coloured natural antioxidant with potent biological activities and diverse applications. A potential source of melanin is the Siberian apricot (Armeniaca sibirica) whose kernel skin is currently a waste by-product. To explore its potential, melanin from apricot kernel skin was extracted. The molecular mass was determined by gel chromatography and its structure was examined by elemental analysis, UV-Vis, infrared, and solid-state nuclear magnetic resonance ( 13 C-NMR) spectroscopy. In addition, its protective effect against hydrazineinduced hepatic injury in rats was evaluated. The results showed that melanin has < 5% sulphur (S) content, indicating that it consists mostly of eumelanin. Its UV-Vis, infrared and 13 C-NMR spectra were very similar to those of synthetic melanin, although it had relatively high carboxylate, aliphatic, and phenol-skeleton content. Two distinct fractions (2.4 ± 0.12 and 0. ± 560.1 kDa) were detected. Injections of hydrazine at 65 mg/kg body-weight (b.wt.) doses resulted in significant (p < 0.01) increases in lipid peroxidation (malondialdehyde contents) in liver homogenates and serum alanine aminotransferase and aspartate aminotransferase activities (64%, 69%, and 98% increase relative to the controls, respectively). It also induced significant (p < 0.05 or 0.01) decreases in liver homogenate catalase, glutathione peroxidase, and superoxide dismutase activities and reduced glutathione content (48%, 28%, 7%, and 98% reduction, respectively). Administering melanin prior to hydrazine, at 10 mg/kg b.wt., strongly inhibited these changes and ameliorated histopathological hepatic injury. The results indicated that melanin alleviated hydrazine-induced liver injury by relieving oxidative stress, which may provide a novel protective strategy for protection against liver diseases.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Alt and Ast Activities In Serummentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of melanin extracted from apricot (Armeniaca sibirica) and its effect on hydrazine-induced rat hepatic injury

Li¹,

Li²,

Zhao³

2016

ScienceAsia

View full text Add to dashboard Cite

show abstract

“…The liver consists of water, proteins and their degradation products, carbohydrates and lipids, and their breakdown products, as well as coenzymes, vitamins, hormones, and organic substances [1]. The parenchymal cells are also involved in the synthesis ofcoagulation factors; removes unwanted wastes and toxic matter from the ECF [2].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective efficacy of ethanolic extracts of rhizome Curcuma amada Roxb. In experimental rats

Ramnath

Rebellow²,

Seethalakshmi

2018

Ann.Pl.Sci.

View full text Add to dashboard Cite

show abstract

Effects of jujube (Ziziphus jujuba mill.) fruit extracts on oxidative stress: A systematic review and meta‐analysis of rodent studies

Zhu,

Tan

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

This study aimed to evaluate the effects of jujube (Ziziphus jujuba Mill.) fruit extracts on oxidative stress levels in rodent models. Animal studies meeting the inclusion criteria were retrieved from PubMed, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, and VIP Periodical Service Platform. The Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) risk‐of‐bias tool was used to evaluate the risk of bias in the included studies. A meta‐analysis was performed based on the guidelines provided in the Cochrane Handbook for Systematic Reviews of Interventions (CHSRI) by using Stata 17.0 software. Nineteen studies were included in the meta‐analysis. Jujube fruit extracts significantly decreased the level of malonaldehyde (MDA) and increased the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH‐Px). Meanwhile, there was no significant improvement in the catalase (CAT) levels. In addition, there was considerable heterogeneity in the results of the meta‐analysis. The results of the subgroup analysis indicated that the animal model, type of extracts, and source of target parameters may have contributed to the heterogeneity. Jujube fruit extracts are healthy and effective antioxidant dietary supplements that may be an effective adjunctive therapy for diseases in which oxidative stress is a major pathological factor. However, the overall methodological quality of the included studies was low, and additional research is warranted.

show abstract

The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities

Cited by 127 publications

References 14 publications

Characterization of melanin extracted from apricot (Armeniaca sibirica) and its effect on hydrazine-induced rat hepatic injury

Characterization of melanin extracted from apricot (Armeniaca sibirica) and its effect on hydrazine-induced rat hepatic injury

Hepatoprotective efficacy of ethanolic extracts of rhizome Curcuma amada Roxb. In experimental rats

Effects of jujube (Ziziphus jujuba mill.) fruit extracts on oxidative stress: A systematic review and meta‐analysis of rodent studies

Contact Info

Product

Resources

About