The Protective Effect of the Methanolic Extract of Ferula persica in Rat Tongue Neoplasm (Oral Squamous Cell Carcinoma) induced by 4-Nitroquinoline-1-Oxide (4-NQO)

Aghbali, Amirala; Mostafazadeh, Samira; Abbasi, Mehran Mesgari; Fotoohi, Soheila; Abdollahi, Bita; Janani, M.; Khiavi, Monir Moradzadeh

doi:10.5812/ircmj.25710

Cited by 2 publications

(2 citation statements)

References 22 publications

(32 reference statements)

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“…Therefore, the rapid and optimal repair of wounds, along with the reduction of complications, has always been one of the priorities of the treatment teams (Nasiry et al., 2017 ). Besides, there is a continuous search for an optimal treatment, which is cost‐effective with minimal side effects (Aghbali et al., 2016 ). For many years, herbal medicine has a special place in the treatment of various diseases (Maver et al., 2015 ; Nasiry et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Stereological and molecular studies on the effects of Ferula persica extract on wound healing in rats

Huang¹,

Wang²,

Ebrahimzadeh

et al. 2021

Veterinary Medicine & Sci

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Background: Ferula persica is one of the most important traditional medicinal plants that is used to treat various diseases such as diabetes, backache and rheumatism. The aim of the present study was to evaluate the anti-inflammatory and wound healing potential of F. persica using stereological and molecular methods in experimental models. Methods:In the present study, two wound models (circular excision and linear incision) were used. Male Wistar rats were divided into four groups (n = 16), including control, vehicle treated, treated with F. persica extract ointment (5% w/w) and treated with the reference drug (Madecassol). All the animals were treated topically once a day. The circular and linear wounds were treated for 9 and 17 days, respectively. At the end of the study, samples from wounds area were harvested for histology, stereology, immunohistochemistry and molecular assessments to determine the in vivo healing potential and anti-inflammatory activity. Results:We observed significant recovery in macroscopic evaluation of wound healing in the F. persica extract treated group compared with the control and vehicle treated groups (p < 0.05). Histological and stereological assessments showed complete repair of the epidermal layer, increasing fibroblast cells and collagen density, decreasing inflammatory cells and a remarkable degree of neovascularization by determining length density of blood vessels in the extract group, which were significant as compared to the control and vehicle treated groups (p < 0.05). Expressions of TNF-α and TGF-β were found to be decreased and increased (p > 0.05, p < 0.05, respectively), in the extract treated group as compared to the control and vehicle treated groups. Also, greater COX-2 expression could be detected in the control and vehicle treated groups, which was significantly attenuated in the extract group. Conclusion:Our results confirm that the F. persica extract is a valuable source of antioxidant and anti-inflammatory activity and can allow damaged tissue in wounds to recover markedly.

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Section: Introductionmentioning

confidence: 99%

Stereological and molecular studies on the effects of Ferula persica extract on wound healing in rats

Huang¹,

Wang²,

Ebrahimzadeh

et al. 2021

Veterinary Medicine & Sci

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“…Early identi ication and treatment of these oral reactive lesions by dentists can lessen the complications in the future (Sei i and Nosrati, 2010;Aghbali et al, 2016). Knowledge about the frequency of such reactive lesions can help assist dentists in making a better diagnosis and offering appropriate treatment (Zhang et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

Reactive lesions of the oral cavity - A retrospective study

Sivaharini¹,

Sherlin²,

Narayan³

2020

ijrps

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Reactive lesions are tumor-like growth and are non-neoplastic in nature. The external and internal stimuli give rise to reactive lesions. The aim of the study is to determine the prevalence and of the oral reactive lesions in an institutional setup. This is a single center cross-sectional retrospective study where records of patients with reactive lesions were collected from 86000 patients visiting Saveetha Dental College during the time period of June 2019 to March 2020. Descriptive statistical methods were used and recorded on data forms. The data were analyzed using SPSS, chi-square tests. 225 patients were identified with reactive lesions. 81(36.2%) patients had tobacco pouch Keratosis, followed by 59 (26.3%) patients with Keratosis. 144 (64%) patients were not wearing or using any prosthesis. However, 44 (19.6%) patients were using temporary partial dentures and 22 (9.8%) patients were using complete dentures. Of all the cases examined,168 (74.7%) were male 57(25.3%) were female. The most commonly affected anatomical site was the gingiva with 64 (28.4%) patients. A total of 155(68.9%) patients had poor oral hygiene Tobacco pouch keratosis is the most commonly affected lesion. Attention to policies about controlling and preventing tobacco and the risk of malignant transformation must be stressed. Early detection and treatment of reactive lesions by dentists can reduce dentoalveolar complications.

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The Protective Effect of the Methanolic Extract of Ferula persica in Rat Tongue Neoplasm (Oral Squamous Cell Carcinoma) induced by 4-Nitroquinoline-1-Oxide (4-NQO)

Cited by 2 publications

References 22 publications

Stereological and molecular studies on the effects of Ferula persica extract on wound healing in rats

Stereological and molecular studies on the effects of Ferula persica extract on wound healing in rats

Reactive lesions of the oral cavity - A retrospective study

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