The protective effect of sophocarpine in osteoarthritis: An in vitro and in vivo study

Wu, Yifan; Zhu, Xingyu; Kang, Xiaodiao; Huang, Huasong; Yu, Jiale; Pan, Jun; Zhang, Xutong

doi:10.1016/j.intimp.2018.11.046

Cited by 12 publications

(8 citation statements)

References 22 publications

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“…Interestingly, other studies have shown that SPC has anti-inflammatory activity in various cell types and disease models. SPC decreased the expression of pro-inflammatory cytokines in both in vitro and in vivo experiments on chondrocytes, providing effective protection against osteoarthritis (Wu et al, 2019a). In mice hepatocytes, SPC inhibited lipopolysaccharide-induced septic liver injury by downregulating the NF-κB signaling pathway and suppressing inflammation (Jiang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…Sophocarpine (SPC) is a natural quinolizidine alkaloid derived from Sophora flavescens , a traditional Chinese herb that has been used to treat illnesses for nearly 2,000 years (Zhou et al, 2018; Wu et al, 2019a). SPC attenuates wear particle-induced implant loosening (Zhou et al, 2018), and both in vitro and in vivo studies suggest that it has strong anti-inflammatory and pharmacological effects on a variety of human diseases including viral infections, allergies, and cancer (Huang et al, 2016; Zhang et al, 2016; Sang et al, 2017; Zhu and Zhu, 2017; Liu et al, 2017b; Jiang et al, 2018; Li et al, 2018; Zhou et al, 2018; Zhang et al, 2018b; Wu et al, 2019a). Moreover, several previous studies reported that SPC can protect against cardiovascular diseases (Li et al, 2011; Zhang et al, 2012; Li et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Sophocarpine Suppresses NF-κB-Mediated Inflammation Both In Vitro and In Vivo and Inhibits Diabetic Cardiomyopathy

et al. 2019

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Diabetic cardiomyopathy (DCM) is a leading cause of mortality in patients with diabetes. DCM is a leading cause of mortality in patients with diabetes. We used both in vitro and in vivo experiments to investigate the hypothesis that sophocarpine (SPC), a natural quinolizidine alkaloid derived from a Chinese herb, could protect against DCM. We used hyperglycemic myocardial cells and a streptozotocin (STZ)-induced type 1 diabetes mellitus mouse model. SPC protected myocardial cells from hyperglycemia-induced injury by improving mitochondrial function, suppressing inflammation, and inhibiting cardiac apoptosis. The SPC treatment significantly inhibited the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling in high-glucose-stimulated inflammatory responses. Moreover, SPC significantly slowed the development and progression of DCM in STZ-induced diabetic mice. These results show that SPC suppresses NF-κB-mediated inflammation both in vitro and in vivo and may be used to treat DCM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sophocarpine Suppresses NF-κB-Mediated Inflammation Both In Vitro and In Vivo and Inhibits Diabetic Cardiomyopathy

et al. 2019

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“…This cytokine also induces the expression of cyclooxygenase-2 (cox-2) and upregulates prostaglandin E2 (PGE2) concentrations. This enzyme mediates bone synthesis that may be associated with osteophyte formation during OA progression [7]. Furthermore, IL-1β activates all three MAPK pathways (ERK, p38, and JNK).…”

Section: Resultsmentioning

confidence: 99%

Molecular mechanisms of mechanical load-induced osteoarthritis

Fang

Zhou

Jin

et al. 2021

International Orthopaedics (SICOT)

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Introduction Mechanical loading enhances the progression of osteoarthritis. However, its molecular mechanisms have not been established. Objective The aim of this review was to summarize the probable mechanisms of mechanical load-induced osteoarthritis. Methods A comprehensive search strategy was used to search PubMed and EMBASE databases (from the 15th of January 2015 to the 20th of October 2020). Search terms included “osteoarthritis”, “mechanical load”, and “mechanism”. Results Abnormal mechanical loading activates the interleukin-1β, tumour necrosis factor-α, nuclear factor kappa-B, Wnt, transforming growth factor-β, microRNAs pathways, and the oxidative stress pathway. These pathways induce the pathological progression of osteoarthritis. Mechanical stress signal receptors such as integrin, ion channel receptors, hydrogen peroxide-inducible clone-5, Gremlin-1, and transient receptor potential channel 4 are present in the articular cartilages. Conclusion This review highlights the molecular mechanisms of mechanical loading in inducing chondrocyte apoptosis and extracellular matrix degradation. These mechanisms provide potential targets for osteoarthritis prevention and treatment.

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“…They were identified as, sophocarpine 235 , sophoridine ( 240 ), oxysophoridine 242 , matrine ( 246 ), oxymatrine ( 249 ), and lupanine 253 . The role of the hippocampal PI3K/Akt/mTOR signaling of matrine 246 was reported (Wu et al 2019a , b ). Matrine 246 exerts antidepressant-like effects on mice.…”

Section: Biological Effectsmentioning

confidence: 99%

“…Sophocarpine ( 235 ) also exerted a protective effect against ox-LDL-induced endothelial damage (Fang et al 2020 ), via regulating NF-κB signaling pathway (Wu et al 2019b ). The same compound ( 235 ) suppressed NF-κB signalling pathway and attenuated wear particle-induced implant loosening by inhibiting osteoclastogenesis and bone resorption (Zhou et al 2018c ).…”

Section: Biological Effectsmentioning

confidence: 99%

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

2021

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Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third largest family of flowering plants. The genus Sophora comprises approximately 52 species, 19 varieties, and 7 forms that are widely distributed in Asia and mildly in Africa. Sophora species are recognized to be substantial sources of broad spectrum biopertinent secondary metabolites namely flavonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins, benzofuran derivatives, sterols, saponins (mainly triterpene glycosides), oligostilbenes, and mainly alkaloids. Meanwhile, extracts and isolated compounds from Sophora have been identified to possess several health-promising effects including anti-inflammatory, anti-arthritic, antiplatelets, antipyretic, anticancer, antiviral, antimicrobial, antioxidant, anti-osteoporosis, anti-ulcerative colitis, antidiabetic, anti-obesity, antidiarrheal, and insecticidal activities. Herein, the present review aims to provide comprehensive details about the phytochemicals and biological effects of Sophora species. The review spotlighted on the promising phytonutrients extracted from Sophora and their plethora of bioactivities. The review also clarifies the remaining gaps and thus qualifies and supplies a platform for further investigations of these compounds.

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The protective effect of sophocarpine in osteoarthritis: An in vitro and in vivo study

Cited by 12 publications

References 22 publications

Sophocarpine Suppresses NF-κB-Mediated Inflammation Both In Vitro and In Vivo and Inhibits Diabetic Cardiomyopathy

Sophocarpine Suppresses NF-κB-Mediated Inflammation Both In Vitro and In Vivo and Inhibits Diabetic Cardiomyopathy

Molecular mechanisms of mechanical load-induced osteoarthritis

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives

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