The protective effect of single dose tadalafil in contrast-induced nephropathy: An experimental study

Özbek, Kerem; Ceyhan, Köksal; Koç, Fatih; Söğüt, Erkan; Altunkaş, Fatih; Karayakalı, Metin; Çelik, Ataç; Kadı, Hasan; Köseoğlu, Reşit Doğan; Özer, Orhan

doi:10.5152/akd.2014.5380

Cited by 18 publications

(27 citation statements)

References 30 publications

(32 reference statements)

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“…Özbek et al reported, in agreement with our results, that tadalafil exhibited a protective effect against kidney damage (25). This may be attributed to the cGMP/NO level that decreases during sepsis being protected by tadalafil.…”

Section: Discussionsupporting

confidence: 93%

The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study

et al. 2017

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Introduction Sepsis is an inflammatory reaction to bacteria involving the whole body and is a significant cause of mortality and economic costs. The purpose of this research was to determine whether tadalafil exhibits a preventive effect on sepsis in a septic model induced in rats with cecal ligation and puncture (CLP).Materials and Methods Rats were randomly separated into groups, 10 rats in each: (i) a sham (control) group, (ii) an untreated sepsis group, (iii) a sepsis group treated with 5mg/kg tadalafil and (iv) a sepsis group treated with 10mg/kg tadalafil. A polymicrobial sepsis model was induced in rats using CLP. Rats were sacrificed after 16h, and blood and kidney tissues were collected for biochemical and histopathological study.Results Levels of the inflammatory parameter IL-6 decreased significantly in the sepsis groups receiving tadalafil in comparison with the untreated sepsis group (p<0.05). In terms of histopathology, inflammation scores investigated in kidney tissues decreased significantly in the sepsis groups receiving tadalafil compared to the untreated sepsis group (p<0.05). In addition, levels of creatinine and cystatin C measured in septic rats receiving tadalafil were lower by a clear degree than in septic rats (p<0.05).Conclusion In this study, tadalafil exhibited a preventive effect for sepsis-related damage by suppressing inflammation in serum and kidney tissue of septic rats in a polymicrobial sepsis model induced with CLP.

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Section: Discussionsupporting

confidence: 93%

The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study

et al. 2017

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“…23 In addition, Ozbek et al showed that acute administration of tadalafil induced significant lowering of serum creatinine and blood urea nitrogen (BUN) values and also decreased serum and renal tissue malondialdehyde (MDA) levels, thus tadalafil protected rat kidney against contrastinduced nephropathy. 24 The hyperglycemia associated with diabetes can cause cellular changes in glomerular basement membrane and connective tissues supporting the capillary loops leading to glomerulosclerosis. 25 The histopathological findings validate these findings.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of tadalafil in diabetic nephropathy induced rat model

Elhawary

Allah

2017

Int J Basic Clin Pharmacol

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INTRODUCTIONDiabetes mellitus (DM) is a major global health problem that causes several micro-and macro-vascular complications. Among these is diabetic nephropathy (DN). DN is the main cause of end-stage renal disease and is associated with a high morbidity and mortality. It develops due to a complex interaction between metabolic and haemodynamic pathophysiological factors, which lead to renal damage. In the earliest stage of DN, patient usually presents with an increase in urinary albumin excretion (microalbuminuria) which progress to macroalbuminuria (more than 300 mg in a 24-hour collection) and later renal insufficiency. 1Among the various mechanisms involved in the pathogenesis of diabetic nephropathy, abnormalities in renal nitric oxide (NO) generation has attracted a lot of attention. NO is postulated to play a protective role towards ischemic injuries of vascular tissues including renal vascular endothelium, an action mediated via cyclic guanosine monophosphate (cGMP) which initiates renal vascular smooth muscle relaxation.2 NO plays numerous physiological roles in the kidney, including control of renal and glomerular hemodynamics, dilates both the ABSTRACT Background: Among various mechanisms involved in the pathogenesis of diabetic nephropathy (DN), abnormalities in renal nitric oxide (NO) generation has attracted a lot of attention. Tadalafil, a competitive inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 commonly used in the treatment of erectile dysfunction was suggested to play a potential prophylactic role for DN. However, this role has not been fully elucidated. The present study was designed to explore the potential beneficial effect of low-dose tadalafil on the progression of diabetic nephropathy in streptozotocin (STZ) induced diabetic rat model. Methods: After injection of STZ and verifying establishment of diabetes, rats were divided into 4 groups: control, diabetic-control, tadalafil-treated nondiabetic, and tadalafil-treated diabetic groups. Biochemical and hemodynamic parameters affecting the renal function such as blood glucose level, serum level of urea and creatinine, renal blood flow, urine volume, urinary albumin excretion, Na+ and K+ excretion, renal level of nitrite and nitrate, plus renal tissues antioxidant parameters (total antioxidant capacity, superoxide dismutase activity and glutathione content) were detected 8 weeks after administration of tadalafil. Histopathological and electron microscopy examination were performed. Results: Our results demonstrated that tadalafil attenuated the glycemic, renal biochemical, microscopic and ultramicroscopic changes/injuries caused by STZ-induced diabetes. Tadalafil could effectively increase renal blood flow and ameliorate glomerular basement membrane thickening. Conclusions: From the results it can be concluded that tadalafil protects rats against streptozotocin-induced DN possibly, in part, through its effect on renal nitric oxide level and its antioxidant activity.

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“…Tadalafil increases the level of cGMP by blocking the enzyme phosphodiesterase-5, thereby increasing the level of nitric oxide and leading to vasodilation [26]. These findings may indicate the importance of the endothelium in the formation and inhibition of contrast nephropathy.…”

Section: Discussionmentioning

confidence: 96%

Contrast-Induced Nephropathy Is Less Common in Patients with Good Coronary Collateral Circulation

2017

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Background/Aims: Contrast-induced nephropathy (CIN) is a typically reversible type of acute renal failure that develops after exposure to contrast agents; underlying endothelial dysfunction is thought to be an important risk factor for CIN. Although the mechanism of coronary collateral circulation (CCC) is not fully understood, a pivotal role of the endothelium has been reported in many studies. The aim of this study was to investigate whether there is a relationship between CCC and CIN. Methods: Patients with at least one occluded major coronary artery and blood creatinine analyses performed before and on the second day after angiography were included in the study. CIN was defined as a 25% or greater elevation of creatinine on the second day after exposure to the contrast agent. Collateral grading was performed according to the Rentrop classification. Patients were grouped according to whether they developed CIN or not, i.e., CIN(-) and CIN(+) group. Results: A total of 214 patients who met the inclusion criteria were included in the study. CIN was diagnosed in 43 patients (20.1%) in the study population. Good CCC was identified in 112 patients (65.5%) in the CIN(-) group, whereas it was identified in 13 patients (30.2%) in the CIN(+) group. In the CIN(-) group, good CCC was significantly more frequent (p < 0.001). Furthermore, collateral circulation was an independent predictor of CIN. Conclusion: Good collateral circulation was associated with a lower frequency of CIN, and poor collateral circulation was an independent predictor of CIN.

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The protective effect of single dose tadalafil in contrast-induced nephropathy: An experimental study

Cited by 18 publications

References 30 publications

The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study

The effect of tadalafil therapy on kidney damage caused by sepsis in a polymicrobial septic model induced in rats: a biochemical and histopathological study

Protective effect of tadalafil in diabetic nephropathy induced rat model

Contrast-Induced Nephropathy Is Less Common in Patients with Good Coronary Collateral Circulation

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