The Protective Effect of Selenium on the Chicken Pancreas against Cadmium Toxicity via Alleviating Oxidative Stress and Autophagy

Liu, Ruohan; Jia, Tiantian; Cui, Yuan; Lin, Hongjin; Li, Shu

doi:10.1007/s12011-017-1186-9

Cited by 31 publications

(15 citation statements)

References 41 publications

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“…Se was reported by one of the articles to alleviate spleen toxicity in a chicken model induced by Pb via the modulation of oxidative stress, in ammation, and autophagy [12]. Se alleviated protein increase of ATG5, Beclin1, Dynein, LC3-I, and LC3-II and protein decrease of mTOR in Cd-induced chicken pancreas [58]. In our study, all alterations caused by Pb were ameliorated by treatment with Se.…”

Section: Discussionsupporting

confidence: 63%

Se Alleviated Oxidative Stress-Mediated Complex Poisoning Mechanism in Pb-Treated Chicken Kidneys: Inflammation, Heat Shock Response, and Autophagy

Miao

Wang

et al. 2021

Preprint

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Background: Lead (Pb) is a toxic environmental pollutant and can exerts toxicity in kidneys. It is known that selenium (Se) has an antagonistic effect on Pb poisoning. However, biological events during the process were not well understood in chicken kidneys.Methods: One hundred and eighty male Hyline chickens (7-day-old) were randomly divided into the control group (offering standard diet and potable water), the Se group (offering Na2SeO3-added standard diet and potable water), the Pb group (offering standard diet and (CH3OO)2Pb-added potable water), and the Pb+Se group (offering Na2SeO3-added standard diet and (CH3OO)2Pb-added potable water). On 30th, 60th, and 90th days, kidneys were removed to perform the studies of histological structure, oxidative stress indicators, cytokines, heat shock proteins, and autophagy in the chicken kidneys.Results: The experimental results indicated that Pb poisoning changed renal histological structure; decreased catalase, glutathione-s-transferase, and total antioxidative capacity activities; increased hydrogen peroxide content; induced mRNA and protein expression of heat shock proteins; inhibited interleukin (IL)-2 mRNA expression, and induced IL-4 and IL-12β mRNA expression; inhibited mammalian target of rapamycin mRNA and protein expression, and induced autophagy-related gene mRNA and protein expression in the chicken kidneys. Supplement of Se mitigated the above changes caused by Pb.Conclusion: Our research strengthens the evidence that Pb induced oxidative stress, inflammation, heat shock response, and autophagy and Se administration alleviated Pb poisoning through mitigating oxidative stress in the chicken kidneys.

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Section: Discussionsupporting

confidence: 63%

Se Alleviated Oxidative Stress-Mediated Complex Poisoning Mechanism in Pb-Treated Chicken Kidneys: Inflammation, Heat Shock Response, and Autophagy

Miao

Wang

et al. 2021

Preprint

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“…Secondly, the Cd content of organs was not determined. Several studies reported that the pancreas is one of the target organs of Cd and Cd exposure produced a time-dependent Cd accumulation in the pancreas [16, 30, 31]. Substantial Cd concentration in the pancreas in present long-term Cd exposure study is speculated.…”

Section: Discussionmentioning

confidence: 69%

Decreased Insulin Secretion but Unchanged Glucose Homeostasis in Cadmium-Exposed Male C57BL/6 Mice

et al. 2019

Journal of Toxicology

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Cadmium (Cd) is a well-known toxic metal element that is largely distributed in the environment. Cd causes toxicity to most organs. Accumulating evidence suggests that Cd exposure is associated with islet dysfunction and development of diabetes, but the association remains controversial. The aim of this study is to evaluate the possible effects of chronic Cd exposure on glucose metabolism in male C57BL/6 mice. Mice were intraperitoneally injected with CdCl2 solution (1 mg.kg−1) twice a week for 24 weeks. Fasting blood glucose (FBG) levels and body weights were measured weekly. After 24 weeks, the intraperitoneal glucose tolerance test (IPGTT), intraperitoneal insulin tolerance test (IPITT), and fasting serum insulin (FSI) level test were performed. The insulin resistance index (HOMA-IR) and pancreatic β cell function index (HOMA-β) were calculated and analyzed. The expression of insulin receptor (IR) in mouse liver was detected by real-time PCR. Pancreatic tissue was collected for histological examination. The results demonstrated that FBG, IPGTT, HOMA-IR, and HOMA-β were identical between Cd exposure and control mice. In contract, mean fasting serum insulin level, area under the curve (AUC) of IPITT, and IR expression in livers of Cd-exposed mice decreased significantly compared with control mice. Cd administration induced islet atrophy and decreased islet area. The results suggested that Cd exposure decreased insulin secretion and maintained glucose homeostasis in male C57BL/6 mice and that pancreatic functions should be monitored in populations chronically exposed to Cd.

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“…Cd exposure could trigger significant increase in blood glucose concentration and lipid peroxidation and significant decrease in body weight, blood insulin level, GSH, and activity of antioxidant enzymes in pancreatic tissue [45]. Liu [46] found that Cd concentration and MDA content were elevated and antioxidant activity markers (CAT, SOD, GSH-Px, and T-AOC) were decreased in pancreas of chickens exposed to Cd. Similarly, Cd treatment elevated the MDA concentration and decreased levels of GSH, SOD, and CAT in male Wistar albino rats [47].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Protection Against Cadmium-Induced Oxidative Stress in Pancreas of Swiss Albino Mice

Sharma

Anu

2018

Asian J Pharm Clin Res

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Objective: This study was planned to explore the protective efficacy of Curcuma longa (curcumin) against cadmium chloride (CdCl2)-induced oxidative stress in pancreatic tissue of albino mice.Methods: A total of 40 albino mice were equally divided into eight groups (five mice for each). The mice were kept on standard feed and water ad libitum. Control Groups 1 and 5 mice were given equal amount of distilled water, Groups 2 and 6 mice received 1 mg/kg body weight of CdCl2 on alternate days, and Group 3 and 7 received 1 mg/kg body weight of CdCl2 on alternate days and 100 mg/kg body weight of curcumin every day. Groups 4 and 8 received 100 mg/kg body weight of curcumin daily and were kept as positive control. Autopsies were done on 15 and 45 days post-treatment. The pancreas was collected from each mouse and homogenized for biochemical study.Results: The results of the present study revealed that Cd-induced oxidative stress depleted the antioxidant scavenger system and curcumin showed free radical scavenging potential. The activities of antioxidant enzymes, i.e., superoxide dismutase, catalase, glutathione peroxidase were observed to be significantly decreased, and methylenedioxyamphetamine concentration was increased in CdCl2-treated group which was restored to normal level after curcumin treatment.Conclusion: It can be concluded that curcumin acts as a powerful and beneficial antioxidant against oxidative stress by scavenging the free radicals produced by CdCl2.

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The Protective Effect of Selenium on the Chicken Pancreas against Cadmium Toxicity via Alleviating Oxidative Stress and Autophagy

Cited by 31 publications

References 41 publications

Se Alleviated Oxidative Stress-Mediated Complex Poisoning Mechanism in Pb-Treated Chicken Kidneys: Inflammation, Heat Shock Response, and Autophagy

Se Alleviated Oxidative Stress-Mediated Complex Poisoning Mechanism in Pb-Treated Chicken Kidneys: Inflammation, Heat Shock Response, and Autophagy

Decreased Insulin Secretion but Unchanged Glucose Homeostasis in Cadmium-Exposed Male C57BL/6 Mice

Curcumin Protection Against Cadmium-Induced Oxidative Stress in Pancreas of Swiss Albino Mice

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