The protective effect of rutin against lipopolysaccharide induced acute lung injury in mice based on the pharmacokinetic and pharmacodynamic combination model

Tian, Chunlian; Shao, Yi; Jin, Zhaodong; Yh, Liang; Li, Chongyang; Qu, Chenghu; Sun, Sheng; Cui, Cai-Lian; Liu, Mingchun

doi:10.1016/j.jpba.2021.114480

Cited by 14 publications

(9 citation statements)

References 18 publications

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“…This resulted in an inability to reach the concentration of effective inhibition of an inflammation concentration of 5 mg/kg. 40 Together, our results demonstrated that R-CDs can effectively inhibit pulmonary infections caused by MRSA but the current formulation lacks good therapeutic effects for lung injury treatment. Previous studies examined CDs applications for wound infections using nitrogen-doped and Au-and Agmodified CDs that exhibited strong antimicrobial activity and promoted wound healing.…”

Section: Antibacterial Activity Of R-cdsmentioning

confidence: 70%

“…The tissue damage was most likely not alleviated due to the low rutin loading in the R-CDs. This resulted in an inability to reach the concentration of effective inhibition of an inflammation concentration of 5 mg/kg . Together, our results demonstrated that R-CDs can effectively inhibit pulmonary infections caused by MRSA but the current formulation lacks good therapeutic effects for lung injury treatment.…”

Section: Results and Discussionmentioning

confidence: 85%

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Rutin-Loaded Carbon Dots for Management of Methicillin-Resistant Staphylococcus aureus Lung Infection

Lang,

Zhao,

Sun

et al. 2024

ACS Appl. Nano Mater.

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Human and animal infections due to multidrug-resistant bacterial pathogens are currently a global health threat. The design and development of antibacterial agents and alternative treatment strategies remain challenges in therapeutic and clinical applications. Herein, we loaded the flavone rutin onto carbon dots (R-CDs) using a one-step hydrothermal/self-assembly method. The minimum inhibitory concentration (MIC) of R-CDs against a methicillin-resistant Staphylococcus aureus (MRSA) strain was 32 μg/mL. MRSA exposed to R-CDs in vitro displayed evidence of cell membrane destruction and increased permeability, leading to a bactericidal effect. Efficient antibacterial effects were further demonstrated in vivo using a mouse model of pulmonary infection with MRSA. The R-CDs were also biocompatibility in vitro and in vivo. Therefore, the R-CDs have potential applications in the treatment of bacterial infections and are an alternative candidate to traditional antibiotic treatment. The present formulation is suitable for testing against MRSA infections in the lung.

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Section: Antibacterial Activity Of R-cdsmentioning

confidence: 70%

Section: Results and Discussionmentioning

confidence: 85%

Rutin-Loaded Carbon Dots for Management of Methicillin-Resistant Staphylococcus aureus Lung Infection

Lang,

Zhao,

Sun

et al. 2024

ACS Appl. Nano Mater.

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“…Quercitrin has a strong antioxidant effect and can inhibit apoptosis and protect human bronchial epithelial cells from oxidative damage (Cincin et al, 2014; Zhi et al, 2016). Rutin can decrease the synthesis of inflammatory factors and suppress the protein expression of TLR4 to improve lung damage (Tian et al, 2022). Rutin can also inhibit the expression of neutrophil infiltration, iNOS and VCAM − 1, effectively improving LPS‐induced ALI (Huang et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

The potential mechanism of Choulingdan mixture in improving acute lung injury based on HPLC–Q‐TOF–MS, network pharmacology and in vivo experiments

Wang

et al. 2023

Biomedical Chromatography

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Choulingdan mixture (CLDM) is an empirical clinical prescription for the adjuvant treatment of acute lung injury (ALI). CLDM has been used for almost 30 years in the clinic. However, its mechanism for improving ALI still needs to be investigated. In this study, high‐performance liquid chromatography–quadrupole/time‐of‐flight mass spectrometry (HPLC–Q‐TOF–MS/MS) was applied to characterize the overall chemical composition of CLDM. A total of 93 ingredients were characterized, including 25 flavonoids, 20 organic acids, 11 saponins, nine terpenoids, seven tannins and 21 other compounds. Then network pharmacology was applied to predict the potential bioactive components, target genes and signaling pathways of CLDM in improving ALI. Additionally, molecular docking was performed to demonstrate the interaction between the active ingredients and the disease targets. Finally, animal experiments further confirmed that CLDM significantly inhibits pulmonary inflammation, pulmonary edema and oxidative stress in lipopolysaccharide‐induced ALI mice by inhibiting the PI3K–AKT signaling pathway. This study enhanced the amount and accuracy of compounds of CLDM and provided new insights into CLDM preventing and treating ALI.

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“…Researches on its material basis, in vivo processes, pharmacological effects, and their interrelationships have become quite complex. The application of PK-PD model to the study of TCM compound is of great significance to clarify the material basis, the mechanism of action, and the interrelationships [26][27][28]. Due to the large individual differences in animals and many interference factors, different individuals may show different responses to pharmacodynamic indexes.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics and pharmacodynamics of bioactive compounds in Penyanqing preparation in THP-1 inflammatory cells induced by Lipopolysaccharide

Gong

Miao

Zhang

et al. 2022

BMC Complement Med Ther

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Background Penyanqing (PYQ), a traditional Chinese medicine (TCM), has a good clinical efficacy for the treatment of pelvic inflammatory disease (PID). Previously, researches on its anti-inflammatory effect and mechanism in vitro, in silico, and in vivo have been reported by our team. However, the interrelationship between the anti-inflammatory activity and the active compounds in PYQ are not clear. Here, the pharmacokinetics-pharmacodynamics (PK-PD) study was carried out for more proper clinical use. Methods The plasma concentrations of salvianolic acid B (SAB), protocatechualdehyde (PRO), paeoniflorin (PE), astilbin (AST), ferulic acid (FE), and chlorogenic acid (CH) in SD rats after PYQ administration were determined by a selective and rapid HPLC–MS/MS method. In addition, the PK-PD on cell model was used to explore the relationship between the plasma concentration and inflammatory biomarkers (TNF-α, IL-1β). Results The results of this study showed that the six components could reach the peak blood concentration within 0.29 h, indicating the rapid absorption of it. The eliminations of AST, CH, FE, PE, and PRO were relatively fast due to their mean residence times (MRTs) within 3 h, while the elimination of SAB was slower (MRT 5.67 ± 0.66 h). Combined with a THP-1 cell model, there was a significant correlation between inflammatory factors and component plasma concentrations with correlation coefficients in the range of -0.9—-0.746. Correspondingly, the drug-containing plasma obtained at 0.25 h point exhibited the best inhibition effect on production of IL-1β and TNF-α in LPS-induced THP-1 cells. Conclusion The six main components in PYQ could be quickly absorbed, and there was a potential good correlation between their pharmacokinetics and the pharmacodynamics of PYQ.

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The protective effect of rutin against lipopolysaccharide induced acute lung injury in mice based on the pharmacokinetic and pharmacodynamic combination model

Cited by 14 publications

References 18 publications

Rutin-Loaded Carbon Dots for Management of Methicillin-Resistant Staphylococcus aureus Lung Infection

Rutin-Loaded Carbon Dots for Management of Methicillin-Resistant Staphylococcus aureus Lung Infection

The potential mechanism of Choulingdan mixture in improving acute lung injury based on HPLC–Q‐TOF–MS, network pharmacology and in vivo experiments

Pharmacokinetics and pharmacodynamics of bioactive compounds in Penyanqing preparation in THP-1 inflammatory cells induced by Lipopolysaccharide

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