The protective effect of resveratrol against risperidone-induced liver damage through an action on FAS gene expression

Abstract

The purpose of the study is to examine the protective effect of resveratrol on the fatty acid synthase gene expression against the side-effects of risperidone in an experimental model in rat liver. In this study, thirty-five female Spraque-Dawley rats were divided into five groups (n = 7): Control, RIS (2 mg/kg risperidone daily), RSV1 (2 mg/kg risperidone + 20 mg/kg resveratrol), RSV2 (2 mg/kg risperidone + 40 mg/kg resveratrol), and RSV3 group (2 mg/kg risperidone + 80 mg/ kg resveratrol). On treatment day 15, liver tissue was taken for analysis. The resveratrol treatment significantly reduced weight gain as opposed to the risperidone administration. Moreover, the fatty acid synthase gene expression level increased significantly in RSV1 group (p = 0.011). In addition, resveratrol enhanced the total antioxidant status, high-density lipoprotein cholesterol levels and decreased alanine aminotransferase, aspartate aminotransferase, total cholesterol, gamma glutamyl transpeptidase, low density lipoprotein cholesterol, oxidative stress index, triglycerides, and total oxidant status levels significantly (p < 0.05). In conclusion, this study revealed that treatment with resveratrol might protect liver tissue against the side-effects of risperidone over fatty acid synthase gene expression. Resveratrol could be an effective course of therapy for enhancing therapeutic efficacy.

Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review

“…Supporting evidence is derived from the study that demonstrates higher degree of liver injury in experimental mice with omega-3 fatty acid deficiency in response to risperidone treatment (McNamara, Magrisso, Hofacer & Jandacek, 2012). Moreover, mice that have received resveratrol in addition to risperidone treatment suffer from milder degrees of liver injury (Azirak, 2019). Another study performed on rats shows that coenzyme Q10 and N-acetyl cysteine have protective effects against liver injury in rats using risperidone and suggests that effects of risperidone on liver may be mediated via mitochondrial and lysosomal injury (Eftekhari, 2016;Horska, 2017).…”

Molecular Cloning and Characterization of Sirtuin 1 and Its Potential Regulation of Lipid Metabolism and Antioxidant Response in Largemouth Bass (Micropterus salmoides)

“…In mammals, SIRT1 has been demonstrated to be involved in the regulation of hepatic lipogenesis through inhibiting the SREBP-1c activity ( Ponugoti et al, 2010 ). In addition, RSV inclusion significantly down-regulated the expression of FAS in rat liver to prevent liver injury ( Azirak et al, 2019 ), and the inhibitory effect of RSV on the expression of FAS was also observed in 3T3-L1 preadipocytes ( Liang et al, 2013 ). In the present study, parallel with previous findings, the expression of SREBP-1 and lipogenesis-related genes, such as FAS and ACC2, was significantly down-regulated in fish fed the diet supplemented with RSV, and the inhibition of lipogenesis partly account for the decrease of TG content.…”

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

“…Haloperidol, a typical antipsychotic medication, is known to produce oxidative stress that contributes to its versatile side effects. Some initial evidence from resveratrol ameliorated risperidone-induced renal (Bilgiç et al, 2017) and liver damage (Azirak et al, 2019) in female Sprague Dawley rats. It improved liver and kidney function parameters and oxidative stress markers (Azirak et al, 2019;Bilgiç et al, 2017), decreased serum lipids level and fatty acid synthase gene expression (Azirak et al, 2019), as well as reduced body weight gain-a common side effects of atypical antipsychotic drugs (Azirak et al, 2019;Bilgiç et al, 2017).…”

“…Some initial evidence from resveratrol ameliorated risperidone-induced renal (Bilgiç et al, 2017) and liver damage (Azirak et al, 2019) in female Sprague Dawley rats. It improved liver and kidney function parameters and oxidative stress markers (Azirak et al, 2019;Bilgiç et al, 2017), decreased serum lipids level and fatty acid synthase gene expression (Azirak et al, 2019), as well as reduced body weight gain-a common side effects of atypical antipsychotic drugs (Azirak et al, 2019;Bilgiç et al, 2017). It was also demonstrated that resveratrol may alleviate symptoms of tardive dyskinesia which is one of the most serious extrapyramidal symptoms caused by the long-term use of typical antipsychotic drugs in humans.…”