The protective effect of propofol on ionizing radiation-induced hematopoietic system damage in mice

Han, Xiaochen; Sun, Fengtao; Zhang, Ying; Wang, Jinyan; Liu, Qingguo; Gao, Ping; Zhang, Shubo

doi:10.1039/c9ra07262d

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…Ionizing radiation was reported to decrease this hematopoietic system [27,28]. The severity of this effect depends on dose and dose rate [28]. Our study, as seen in Table 1, recognized that radiationexposed blood biomarkers were more affected as compared to the unexposed people.…”

Section: Resultssupporting

confidence: 49%

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The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents

et al. 2022

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The immune system is one of the most significant defenses against environmental insults including natural radiation. The purpose of this preliminary study was to assess the effects of high natural radiation to Mamuju residents, by focusing on immune-related blood cell counts (leukocytes, lymphocytes, monocytes, and granulocytes) and immunoglobulin E (IgE) level. The blood samples were collected from 18 adult residents in a high background radiation area (HBRA) while 18 residents in a normal background radiation area (NBRA) served as a control group. The blood components were measured by using the hematopoietic analyzer, and IgE immune biomarker was measured with ELISA (enzyme-linked immunosorbent assay) according to standard protocols. The data showed that the level of all blood cells, except for monocytes, of residents in HBRA was higher than that of NBRA. Statistical analysis revealed that there was no significant difference (P>0.05) in the blood cell counts and IgE level in both groups and their values were within normal limits. The level of IgE in HBRA was significantly higher than the control area (P≤0.05), as its IgE level in males compared to females in both residents. The relationship between IgE level and age were negative in these residents. From this study, it was concluded that long-term exposure to high radiation may affect the immune system as one of radiation adaptive response.

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Section: Resultssupporting

confidence: 49%

“…The immune response depends on the capacity taken by white blood cells including leukocytes, monocytes, lymphocytes, and granulocytes. Ionizing radiation was reported to decrease this hematopoietic system [27,28]. The severity of this effect depends on dose and dose rate [28].…”

Section: Resultsmentioning

confidence: 99%

The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents

et al. 2022

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“…Radioprotectants have been reported to have the ability to scavenge IR‐induced ROS and effectively reduce related damage (Benson et al., 2016). Most radioprotectants have antioxidant activity, and they can scavenge free radicals and thus reduce damage to human body (Feng et al., 2017; Han et al., 2019). At present, many natural plant compounds have showed various biological activities that may be associated with reducing the damage caused by IR, including tea polyphenol, emodin, quercetin, anthocyanin, polysaccharide, and so on (Mahgoub et al., 2020; Muniyandi et al., 2019; Xu et al., 2021).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of coix seed seedling extract on ⁶⁰Co‐γ radiation‐induced oxidative stress in mice

Xue

Zhu

et al. 2021

Journal of Food Science

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Exposure to ionizing radiation (IR) can cause oxidative damage to human body, leading to various diseases and even death. In this study, the potential radioprotective effect of coix seed seedling extract (CSS‐E) was studied through a model of 60Co‐γ radiation‐induced oxidative stress in mice. Overall radioprotective effect of CSS‐E against radiation‐induced damage was evaluated by biochemical analysis and histopathological analysis. The results showed that CSS‐E could significantly reduce the IR‐induced damage to the hematopoietic system. CSS‐E‐M (200 mg/kg BW) pretreatment could increase the activities of superoxide dismutase in serum, liver, and spleen increased by 31.68%, 45.10%, and 56.67%, respectively, and the glutathione peroxidase levels in serum, liver, and spleen of mice were improved by 19.17%, 41.97%, and 130.56%, respectively. Meanwhile, the glutathione levels of serum, liver, and spleen in CSS‐E‐M group were increased by 17.10%, 35.06%, and 40.71%, respectively. The contents of MDA in different tissues and serum could be reduced by CSS‐E‐M treatment to the normal level. Moreover, CSS‐E could markedly reduce the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in radiation mice, among which CSS‐E‐M group showed maximum restoration with decreased AST and ALT levels by 20.13% and 32.76% as compared against IR group. In conclusion, these results indicated that CSS‐E could be used as a potential natural radioprotectant against IR‐induced damage.

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DNA damage assessment in peripheral blood of Swiss albino mice after combined exposure to volatile anesthetics and 1 or 2 Gy radiotherapy in vivo

Benković

Borojević

Šikić

et al. 2021

International Journal of Radiation Biology

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The protective effect of propofol on ionizing radiation-induced hematopoietic system damage in mice

Abstract: Propofol protects against radiation-induced hematopoietic system damage by reducing cellular ROS, partly through the Nrf2 pathway.

Cited by 4 publications

References 27 publications

The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents

The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents

Protective effect of coix seed seedling extract on ⁶⁰Co‐γ radiation‐induced oxidative stress in mice

DNA damage assessment in peripheral blood of Swiss albino mice after combined exposure to volatile anesthetics and 1 or 2 Gy radiotherapy in vivo

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The protective effect of propofol on ionizing radiation-induced hematopoietic system damage in mice

Abstract: Propofol protects against radiation-induced hematopoietic system damage by reducing cellular ROS, partly through the Nrf2 pathway.

Cited by 4 publications

References 27 publications

The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents

The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents

Protective effect of coix seed seedling extract on 60Co‐γ radiation‐induced oxidative stress in mice

DNA damage assessment in peripheral blood of Swiss albino mice after combined exposure to volatile anesthetics and 1 or 2 Gy radiotherapy in vivo

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Protective effect of coix seed seedling extract on ⁶⁰Co‐γ radiation‐induced oxidative stress in mice