The Protective Effect of Oxygenated Perfluorocarbons (PFCs) on Intestinal Ischemia Reperfusion Injury (I/R) in Rabbits

Abstract

Intraluminal administration of oxygenated PFCs seems that protect the intestine from the I/R injury.

Blood concentrations ofd‐ andl‐lactate in healthy rabbits

“…), whereas another study reported values of 4 · 05 ± 0 · 22, 6 · 80 ± 1 · 22, 5 · 67 ± 1 · 15 and 7 · 14 ± 0 · 58 mmol/L, higher than the concentrations in the present study (Ntinas et al. ). In one of these studies (Gunel et al.…”

“…In another study, d ‐lactate concentrations measured using the lactate oxidase–peroxidase–chromogen sequence, another enzymatic technique, were higher than the values obtained in this study (Ntinas et al. ). However, only four rabbits were used, and sample size may have influenced the results obtained.…”

“…In that study, d-lactate concentrations were lower using the enzymatic technique and it was hypothesised that cross-reactivity or disturbance of enzymatic reaction by endogenous compounds could affect d-lactate values. In another study, d-lactate concentrations measured using the lactate oxidase-peroxidase-chromogen sequence, another enzymatic technique, were higher than the values obtained in this study (Ntinas et al 2010). However, only four rabbits were…”

“…Serum d-lactate concentrations measured in rabbits in this study are different than d-lactate concentrations previously reported. In one study, healthy rabbits had serum d-lactate concentrations of 0 mmol/L (Gunel et al 1998), whereas another study reported values of 4·05 ±0·22, 6·80 ±1·22, 5·67 ±1·15 and 7·14 ±0·58 mmol/L, higher than the concentrations in the present study (Ntinas et al 2010). In one of these studies (Gunel et al 1998), rabbits were fasted overnight.…”

“…Determination of lactate concentrations may be useful and practical to assess tissue perfusion and integrity of the gastrointestinal barrier and allow a more accurate prognosis and means to monitor response to treatment. Previous publications suggest that lactate may be useful in assessing gastrointestinal injury in rabbits (Gunel et al 1998, Ntinas et al 2010.…”