The protective effect of Nigella sativa seeds against monosodium glutamate-induced hepatic dysfunction in rats

Abd-Elkareem, Mahmoud; Soliman, Mahmoud; El-Rahman, M. Abd; Khalil, Nasser S. A. M.

doi:10.1016/j.toxrep.2022.01.014

Cited by 12 publications

(7 citation statements)

References 59 publications

(63 reference statements)

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“…N. Sativa administration protects hepatic tissue from the deleterious effects of toxic metals ( 27 ). In addition, N.sativa provided cytoprotectant by improving the histoarchitecture of the liver and decreasing the number of apoptotic cells ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

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Effect of Allium sativum and Nigella sativa on alleviating aluminum toxicity state in the albino rats

et al. 2022

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The study objective was to evaluate Allium sativum's potential and Nigella Sativa's combination's potential to reduce aluminum toxicity and return to the normal state. In the present study, a hundred albino rats were randomly divided into five equal groups. The first group was used as a control group; the other four groups were exposed to aluminum 1,600 ppm. The second exposed to aluminum only; the third and fourth groups were treated with Allium sativum 5% and Nigella sativa 5%, respectively, while the fifth group was treated with a mix of Allium sativum 2.5% and Nigella sativa 2.5% for 8th weeks. After 8 weeks, the aluminum administration was stopped, and the second group was divided into three groups. The groups were treated with Allium sativum 5% and Nigella sativa 5%, and a mix of Allium sativum 2.5% and Nigella sativa 2.5%, respectively. The first group was the control group (continued from the first experiment). Garlic and Nigella sativa were crushed and added to feed while receiving aluminum chloride daily at a dose of 1.6 ml/l was added to the drinking water. Histopathological changes in the liver, kidney, and testes were investigated after 8 and 16 weeks, and blood samples were collected after 4, 8, and 16 weeks for biochemical blood parameters. The results showed that the histopathological examination of the liver, kidney, and testes showed signs of congestion in blood vessels after aluminum exposure. Meanwhile, the treatment with Allium sativum or Nigella sativum or the mixture between them had positive effects on evading the harmful effects of aluminum in the liver, Kidney, and testes tissues. In addition, there were protective effects for Allium sativum and Nigella sativa against aluminum on serum creatinine, urea, ALT, and AST concentrations. The present study concluded that supplementation with Allium sativum or Nigella sativa or their combination could reduce aluminum toxicity and return the liver, kidney, and testes to normal.

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Section: Discussionmentioning

confidence: 99%

“…The results indicated that N. sativa treatment protects the rat liver from hepatic ischemia-reperfusion injury by increasing antioxidant enzymatic activities significantly ( 29 ). Furthermore, Through its antioxidant and anti-apoptotic properties, N. Sativa was effective in protecting against hepatotoxicity ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Allium sativum and Nigella sativa on alleviating aluminum toxicity state in the albino rats

et al. 2022

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“…Catalase reduces oxidative stress and lipid peroxidation either by protecting the detoxifying enzymes by increasing the efficacy of Nicotineamide Dinucleotide Phosphate (NADPH) or by helping in the elimination of compounds that produce peroxidation in the cell membranes 58 . Since H 2 O 2 acts as a substrate for a specific reaction that generates highly hydroxyl radicals, it is believed that the primary role of catalase in cellular antioxidant defense mechanisms is to reduce the accumulation of H 2 O 2…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-Ulcerogenic Effects of the Crude Extract and Fractions of Dialium guineense Tree Bark in Ethanol-Induced Peptic Ulcer in Albino Rats

Johnlouis,

Sunday,

Adanma

et al. 2024

Asian J. Biol. Sci

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Background and Objective: Medicinal plants contain bioactive molecules with pharmacological potential for managing diseases. Peptic ulcer is a ravaging disease that has been attributed to cases of mortality across the globe and Dialium guineense; a medicinal plant could form bases for its amelioration hence, this study sets out to evaluate the anti-ulcerogenic potentials of a crude ethanol extract and fractions of Dialium guineense stem bark in ethanol-induced ulcer in albino rats. Materials and Methods:The biochemical effects of Dialium guineense stem bark in ethanol-induced ulcers were determined using standard protocols. The SPSS version 22 was used for the one-way ANOVA analysis (p<0.05). Results: For the gastro-protective estimation, ulcer index and percentage protection score of the treatment groups were significantly (p<0.05) lower than those of the untreated groups and the standard drug (omeprazole) in a dose-dependent manner. There were significant (p<0.05) elevations in red blood cell and hemoglobin concentrations respectively in the groups co-treated with different fractions of Dialium guineense. The result also indicated a significant (p<0.05) decrease in the tumor necrotic factor-α and the interleukin-1β concentration across the fractions group compared with the normal group. The result of the antioxidant study showed significant (p<0.05) increases in the superoxide dismutase, catalase activities and glutathione concentrations of the co-treated groups compared to the untreated group. The organ histology showed protected stomach architecture in the co-treated groups compared to that of the negative control which showed full laceration of the stomach wall. Conclusion:Hence, it could be concluded that different fractions of Dialium guineense stem bark extract have an organo-protective activity which could be attributed to its high antioxidant activity as antioxidants have been found to reverse the toxicity caused by pro-oxidants.

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“…NSS has an abundance of redox stabilizers, including thymoquinone, flavonoids, and terpenoids 11 . NSS boosts the transcript level of redox stabilizers 60 , and shifts the cell fate decisions to pro-survival events 61 . By elevating proliferating cell nuclear antigen, TQ stimulates cell multiplication, thereby enhancing the ability of cell to regenerate after tissue injury 62,63 .…”

Section: Discussionmentioning

confidence: 99%

Nigella sativa seeds mitigate the hepatic histo-architectural and ultrastructural changes induced by 4-nonylphenol in Clarias gariepinus

Abd-Elkareem

Sayed

Khalil

et al. 2023

Sci Rep

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Due to its prevalence in aquatic environments and potential cytotoxicity, 4-nonylphenol (4-NP) has garnered considerable attention. As a medicinal plant with numerous biological activities, Nigella sativa (black seed or black cumin) seed (NSS) is widely utilized throughout the world. Consequently, this study aimed to examine the potential protective effects of NSS against 4-NP-induced hepatotoxicity in African catfish (Clarias gariepinus). To achieve this objective, 18 fish (351 ± 3 g) were randomly divided into three equal groups for 21 days. The first group serves as a control which did not receive any treatment except the basal diet. The second and third groups were exposed to 4-NP at a dose of 0.1 mg L−1 of aquarium water and fed a basal diet only or supplemented with 2.5% NSS, respectively. The histological, histochemical, and ultrastructural features of the liver were subsequently evaluated as a damage biomarker of the hepatic tissue. Our results confirmed that 4-NP was a potent hepatotoxic agent, as 4-NP-intoxicated fish exhibited many lesions. Steatohepatitis, ballooning degeneration, sclerosing cholangitis, and coagulative necrosis of melanomacrophagecenters (MMCs) were observed. Hemosiderin, lipofuscin pigments, and proliferation of fibroblasts, kupffer cells, and telocytes were also demonstrated in the livers of 4-NP-intoxicated fish. In addition, decreased glycogen content and increased collagen deposition were observed in the hepatic tissue. Hepatocytes exhibited ultrastructural alterations in the chromatin, rough endoplasmic reticulum, smooth endoplasmic reticulum, mitochondria, lysosomes, and peroxisomes. Co-administration of 2.5% NSS to 4-NP-intoxicated fish significantly reduced these hepatotoxic effects. It nearly preserved the histological, histochemical, and ultrastructural integrity of hepatic tissue.

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The protective effect of Nigella sativa seeds against monosodium glutamate-induced hepatic dysfunction in rats

Abstract: Graphical abstract

Cited by 12 publications

References 59 publications

Effect of Allium sativum and Nigella sativa on alleviating aluminum toxicity state in the albino rats

Effect of Allium sativum and Nigella sativa on alleviating aluminum toxicity state in the albino rats

Evaluation of Anti-Ulcerogenic Effects of the Crude Extract and Fractions of Dialium guineense Tree Bark in Ethanol-Induced Peptic Ulcer in Albino Rats

Nigella sativa seeds mitigate the hepatic histo-architectural and ultrastructural changes induced by 4-nonylphenol in Clarias gariepinus

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