The protective effect of Nigella sativa extract on lung inflammation and oxidative stress induced by lipopolysaccharide in rats

Mokhtari‐Zaer, Amin; Norouzi, Fatemeh; Askari, Vahid Reza; Khazdair, Mohammad Reza; Roshan, Nama Mohammadian; Boskabady, Mohammad Hossein; Hosseini, Mahmoud

doi:10.1016/j.jep.2020.112653

Cited by 62 publications

(43 citation statements)

References 51 publications

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“…It downregulates the expression of the inflammatory mediators such as IFN-γ, TGF-β1, and prostaglandin 2 (PGE 2 ) but upregulates the anti-inflammatory cytokine IL-4. It also exhibits potent antioxidant properties by enhancing the activity of SOD and catalase [ 228 ]. Besides, it attenuates low-grade inflammation in vitro by reducing the levels of IL-1 β and MCP-1 [ 229 ].…”

Section: Anti-inflammatory Role Of Spicesmentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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Background Cytokine storm is the exaggerated immune response often observed in viral infections. It is also intimately linked with the progression of COVID-19 disease as well as associated complications and mortality. Therefore, targeting the cytokine storm might help in reducing COVID-19-associated health complications. The number of COVID-associated deaths (as of January 15, 2021; https://www.worldometers.info/coronavirus/ ) in the USA is high (1199/million) as compared to countries like India is low (110/million). Although the reason behind this is not clear, spices may have some role in explaining this difference. Spices and herbs are used in different traditional medicines, especially in countries such as India to treat various chronic diseases due to their potent antioxidant and anti-inflammatory properties. Aim To evaluate the literature available on the anti-inflammatory properties of some spices which might prove beneficial in the prevention and treatment of COVID-19 associated cytokine storm. Method A detailed literature search has been conducted on PubMed for collecting information pertaining to the COVID-19; the history, origin, key structural features, and mechanism of infection of SARS-CoV-2; the repurposed drugs in use for the management of COVID-19 and the anti-inflammatory role of spices to combat COVID-19 associated cytokine storm. Key findings The literature search resulted in numerous in vitro , in vivo and clinical trials that have reported the potency of spices to exert anti-inflammatory effects by regulating crucial molecular targets for inflammation. Significance As spices are derived from Mother Nature and are inexpensive, they are relatively safer to consume. Therefore, their anti-inflammatory property can be exploited to combat the cytokine storm in COVID-19 patients. This review thus focuses on the current knowledge on the role of spices for the treatment of COVID-19 through suppression of inflammation-linked cytokine storm.

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Section: Anti-inflammatory Role Of Spicesmentioning

confidence: 99%

COVID-19, cytokines, inflammation, and spices: How are they related?

et al. 2021

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“…It is possible that consuming black cumin could be improve symptoms of Covid-19. The protective effect of Nigella sativa extract on lung inflammation and oxidative stress was recently demonstrated in a study in rats treated with lipopolysaccharide (LPS) , where it also limited tissue damage (93). LPS increases counts of WBC, eosinophils, neutrophils, basophils, and monocytes, and of oxidative stress markers in bronchoalveolar fluid and serum, and levels of TGF-β1, IFN-γ, PGE2, and IL-levels (93).…”

Section: Effects Of Natural Products On the Immune Systemmentioning

confidence: 98%

Physical Activity and Natural Products and Minerals in the SARS-CoV-2 Pandemic: An Update

et al. 2021

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Coronavirus-disease 19 (COVID-19) has rapidly become a global public health issue, and there is a desperate need for strategies of prevention, reduction, and treatment to halt the epidemic. The coronavirus affects the immune system, and individuals with a compromised immune system, such as those with diabetes, hypertension, obesity, are more susceptible to this virus. Lifestyle-related variables such as physical activity and nutritional supplements can decrease inflammatory markers, increase anti-inflammatory and antioxidant status, and improve the immune system. Lifestylerelated variables play preventive roles against various infectious diseases including COVID-19. This review highlights the effects of physical activity and nutrients supplements on the immune system and their possible benefits in combating the harms caused by infection with the COVID-19 virus.

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“…Our previous studies showed that intraperitoneal (i.p.) administration of LPS in the rats increased total and differential WBC count, induced oxidative damage by increasing the MDA level and decreasing antioxidant markers, and led to a 1/ 2 imbalance in the blood and the BALF [7][8][9][10]. erefore, reducing oxidative injury and suppression of the inflammatory process could ameliorate LPS-induced tissue damage including lung injury.…”

Section: Introductionmentioning

confidence: 99%

Thymoquinone Ameliorates Lung Inflammation and Pathological Changes Observed in Lipopolysaccharide-Induced Lung Injury

Khazdair

Bargi

Saadat

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Anti-inflammatory, antioxidant, and immunomodulatory effects of thymoquinone (TQ) have been shown. The effects of TQ on lipopolysaccharide- (LPS-) induced inflammation and pathological changes in rats’ lung were investigated in this study. Four groups of rats included (1) control (saline treated); (2) LPS (treated with 1 mg/kg/day i.p. for two weeks); and (3 and 4) 5 or 10 mg/kg TQ i.p. 30 min prior to LPS administration. Total and differential WBC counts in the blood and bronchoalveolar fluid (BALF), TGF-β1, INF-γ, PGE2, and IL-4 levels in the BALF and pathological changes of the lung were evaluated. Total WBC count and eosinophil, neutrophil, and monocyte percentage were increased, but the lymphocyte percentage was reduced in the blood and BALF. The BALF levels of PGE2, TGF-β1, and INF-γ were also increased, but IL-4 level was reduced due to LPS administration. LPS also induced pathological insults in the lung of rats ( P < 0.05 to P < 0.001 for all changes in LPS-exposed animals). Treatment with TQ showed a significant improvement in all changes induced by LPS ( P < 0.05 to P < 0.05 ). TQ showed a protective effect on LPS-induced lung inflammation and pathological changes in rats which suggested a therapeutic potential for TQ on lung injury.

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The protective effect of Nigella sativa extract on lung inflammation and oxidative stress induced by lipopolysaccharide in rats

Cited by 62 publications

References 51 publications

COVID-19, cytokines, inflammation, and spices: How are they related?

COVID-19, cytokines, inflammation, and spices: How are they related?

Physical Activity and Natural Products and Minerals in the SARS-CoV-2 Pandemic: An Update

Thymoquinone Ameliorates Lung Inflammation and Pathological Changes Observed in Lipopolysaccharide-Induced Lung Injury

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