The Protective Effect of Nigella sativa Oil against Experimentally Induced Cisplatin Ototoxicity: An Animal Study

Abstract

Journal of International Advanced Otology requires and encourages the authors and the individuals involved in the evaluation process of submitted manuscripts to disclose any existing or potential conflicts of interests, including financial, consultant, and institutional, that might lead to potential bias or a conflict of interest. Any financial grants or other support received for a submitted study from individuals or institutions should be disclosed to the Editorial Board. To disclose a potential conflict of interest, the ICMJE Potential Conflict of Interest Disclosure Form should be filled in and submitted by all contributing authors. Cases of a potential conflict of interest of the editors, authors, or reviewers are resolved by the journal's Editorial Board within the scope of COPE and ICMJE guidelines. The Editorial Board of the journal handles all appeal and complaint cases within the scope of COPE guidelines. In such cases, authors should get in direct contact with the editorial office regarding their appeals and complaints. When needed, an ombudsperson may be assigned to resolve cases that cannot be resolved internally.

Otoprotective effects of farnesene against oxidative damage induced by paclitaxel

“…Exogenous antioxidants such as Nigella sativa oil 45 , pycnogenol 46 , pomegranate 47 , resveratrol 48 , and gallic acid 17 have been utilized as otoprotectors in research.…”

“…The antioxidant qualities of FNS, its protective action against neurons, and the neurotoxic effect of PCX are thought to cause ototoxicity through peripheral auditory neurons, as stated in the previous research 11,15 , which drove our research. It is noteworthy that substances with antioxidant properties are generally studied in ototoxicity studies 20,[45][46][47][48] . Despite this knowledge and outcomes, research on the effects of FNS with antioxidant qualities on ototoxicity is limited in the literature.…”

Otoprotective Mechanisms of Carvone As An Antioxidant Agent Against Ototoxic Damage Caused By Paclitaxel

“…In the related literature, various exogenous otoprotector substances, such as thymoquinone (24), carvacrol (3), curcumin (25), and resveratrol (26), have been utilized to reduce ototoxicity caused by various chemotherapeutics by "scavenging" free radicals at a preliminary phase and mitigating oxidative injury via their antioxidant properties.…”

Molecular Targets of Thymoquinone Protection Against Cisplatin-Induced Organ Toxicity: A Literature Review

“…Cisplatin has shown successful results against cancer, its clinical use is very limited due to serious side effects in the form of toxicity to several organs, including ototoxicity, gastrointestinal toxicity, nephrotoxicity, and hepatotoxicity [3].…”

“…Cisplatin is the most potent chemotherapy drug widely used for cancer treatment and the major choice of therapy for epithelial malignancies, especially head and neck cancer [1,2]. Although cisplatin has shown successful results against cancer, its clinical use is very limited due to serious side effects in the form of toxicity to several organs, including ototoxicity, gastrointestinal toxicity, nephrotoxicity, and hepatotoxicity [3]. Cisplatin causes toxicity through two pathways, namely the intrinsic and the extrinsic pathways.…”