The protective effect of neonatal oral administration of oleanolic acid against the subsequent development of fructose-induced metabolic dysfunction in male and female rats

Nyakudya, Trevor Tapiwa; Mukwevho, Emmanuel; Erlwanger, Kennedy H.

doi:10.1186/s12986-018-0314-7

Cited by 14 publications

(20 citation statements)

References 90 publications

(105 reference statements)

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“…Nonetheless, according to the literature, OA improves beta-cell function through increasing insulin biosynthesis and secretion and also improves glucose tolerance [10]. This idea coincides with different studies included in our review that reported improvements of glucose tolerance both in glucose [35,36,38,39,40,42,46] and in insulin [35,42] tolerance tests, as well as reductions of FBG [30,35,38,42,43,44].…”

Section: Discussionsupporting

confidence: 86%

“…Two studies performed by Nyakudya et al [46,47] assessed the protective long-term effects of neonatal intake of OA in rats. These animals were administered OA, a high-fructose (HF) solution, or OA combined with the HF solution during their second week of life.…”

Section: Resultsmentioning

confidence: 99%

“…From postnatal day 56 until the end of the experiment, half of each group received either distilled water or a fructose-rich solution. At the end of the first experiment [46], a significant increase in glucose in the OGTT test was observed in both administration periods in comparison to all of the OA-treated female rats. Moreover, both HF solution-fed male and female rats had a significant higher HOMA-IR index than their respective OA-fed male and female rats in both periods.…”

Section: Resultsmentioning

confidence: 99%

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Potential Protective Effect of Oleanolic Acid on the Components of Metabolic Syndrome: A Systematic Review

Fernández-Aparicio

Schmidt-RíoValle

Perona

et al. 2019

JCM

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The high prevalence of obesity is a serious public health problem in today’s world. Both obesity and insulin resistance favor the development of metabolic syndrome (MetS), which is associated with a number of pathologies, especially type 2 diabetes mellitus, and cardiovascular diseases. This serious problem highlights the need to search for new natural compounds to be employed in therapeutic and preventive strategies, such as oleanolic acid (OA). This research aimed to systematically review the effects of OA on the main components of MetS as well as oxidative stress in clinical trials and experimental animal studies. Databases searched included PubMed, Medline, Web of Science, Scopus, EMBASE, Cochrane, and CINAHL from 2013 to 2019. Thus, both animal studies (n = 23) and human clinical trials (n = 1) were included in our review to assess the effects of OA formulations on parameters concerning insulin resistance and the MetS components. The methodological quality assessment was performed through using the SYRCLE’s Risk of Bias for animal studies and the Jadad scale. According to the studies in our review, OA improves blood pressure levels, hypertriglyceridemia, hyperglycemia, oxidative stress, and insulin resistance. Although there is scientific evidence that OA has beneficial effects in the prevention and treatment of MetS and insulin resistance, more experimental studies and randomized clinical trials are needed to guarantee its effectiveness.

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Section: Discussionsupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Potential Protective Effect of Oleanolic Acid on the Components of Metabolic Syndrome: A Systematic Review

Fernández-Aparicio

Schmidt-RíoValle

Perona

et al. 2019

JCM

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“…Seven day old pups were randomly divided into the five groups namely the 0.5% v / v dimethylsulphoxide in distilled water vehicle control (CON), Oleanolic acid (OA, 60 mg/kg), High fructose diet (HF, 20% w / v ), High fructose diet combined with oleanolic acid (HF+OA), and High fructose diet combined with metformin (HF+MET, 500 mg/kg). The doses of oleanolic acid and metformin used werepreviouslyused in other metabolic studies in rats [ 28 , 29 ]. The treatments were administered by orogastric gavage (10 mL/kg) once dailyuntil day 14.…”

Section: Methodsmentioning

confidence: 99%

Long-Term Impact of Neonatal Intake of Oleanolic Acid on the Expression of AMP-Activated Protein Kinase, Adiponectin and Inflammatory Cytokines in Rats Fed with a High Fructose Diet

et al. 2019

Self Cite

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AMP-activated protein kinase (AMPK) is known to regulate both glucose and lipid metabolism, which play vital roles in the development of metabolic syndrome. One way of regulating AMPK is through hormonal activation using adiponectin. Patients diagnosed with type-2 diabetes (T2D) and obesity exhibit low adiponectin concentration levels in their blood. Moreover, studies have also shown that inflammatory processes play a significant role in the etiology of these metabolic diseases. In this study, the long-term effects of neonatal intake of oleanolic acid (OA) on the AMPK gene, genes associated with glucose transport and lipid metabolism, adiponectin levels, and inflammatory biomarkers in rats fed with a high fructose diet were investigated. Seven day old pups were randomly divided into five groups and treated as follows; 0.5% dimethylsulphoxide v/v in distilled water vehicle control (CON), oleanolic acid (OA, 60 mg/kg), high fructose diet (HF, 20% w/v), high fructose diet combined with oleanolic acid (HF+OA), and high fructose diet combined with metformin (HF+MET, 500 mg/kg). The treatments were administered once daily until day 14. The rats were then weaned at day 21 and fed standard rat chow and had ad libitum access to plain drinking water until day 112. The quantitative polymerase chain reaction (qPCR) was used to analyze the gene expressions of AMPK, Glut-4, Cpt-1, AdipoR1, AdipoR2, TNF-α, and IL-6 in the skeletal muscles. Bio-Plex Pro magnetic bead-based assay was used to measure plasma levels of inflammatory markers (TNF-α, IL-6, VEGF, and MCP-1) while ELISA kits were used to measure adiponectin concentration in blood plasma. The results obtained in this study showed that neonatal supplementation with OA significantly increased AMPK gene expression approximately ~4-fold in OA fed rats compared to those that were fed with HF alone. In addition, glut-4 gene expression was also significantly higher in the OA treatment group compared to all the other experimental groups except the CON group whereas Cpt-1 gene was more expressed when OA was administered alone. Together, these results indicated that OA can play a role in glucose and lipid metabolism gene regulation. Furthermore, the results showed that the OA group had ~1.5-fold increase in adiponectin concentration when comparedto the HF group. Moreover, HF increased levels of inflammatory cytokines, which was attenuated by neonatal administration of OA. Plasma concentration and gene expression in the skeletal muscle for TNF-α and IL-6 were significantly increased in rats that were treated with HF alone when compared to all the other groups. On the contrary, the high levels of TNF-α and IL-6 were reduced when OA was administered. These findings suggest that intake of oleanolic acid during the neonatal stage of development could be a potential strategic intervention for the long-term prevention of metabolic diseases such as T2D and obesity.

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“…Oral administration of OA in neonatal rats demonstrated a remarkable degree of protection from the adverse effects of HF consumption in adulthood. At 60 mg/kg, OA for 7 days normalized fasting blood glucose and homeostatic model assessment of insulin resistance (HOMA-IR) in adulthood [15]. OA offered significant protection against the development of insulin resistance via the upregulation of adiponectin levels by approximately 1.5-fold.…”

Section: Insulin Resistance and Glucose Metabolismmentioning

confidence: 99%

Prophylactic Use of Natural Products against Developmentally Programmed Metabolic Syndrome

et al. 2021

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Parental dietary choices and/or nutritional interventions in the offspring are critical to early life development, especially during the periods of active developmental plasticity in the offspring. Exposure to a high-fructose, high-fat diet during the fetal or neonatal period predisposes the affected individuals to the development of one or more features of metabolic syndrome, such as dyslipidemia, insulin resistance, diabetes, and associated cardiovascular diseases, later in their life. Owing to the increasing global prevalence of metabolic syndrome and multiple side effects that accompany conventional medicines, much attention is directed towards medicinal plants and phytochemicals as alternative interventions. Several studies have investigated the potential of natural agents to prevent programmed metabolic syndrome. This present review, therefore, highlights an inextricable relationship between the administration of medicinal plants or phytochemicals during the intrauterine or neonatal period, and the prevention of metabolic dysfunction in adulthood, while exploring the mechanisms by which they exert such an effect. The review also identifies plant products as a novel approach to the prevention and management of metabolic syndrome.

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The protective effect of neonatal oral administration of oleanolic acid against the subsequent development of fructose-induced metabolic dysfunction in male and female rats

Cited by 14 publications

References 90 publications

Potential Protective Effect of Oleanolic Acid on the Components of Metabolic Syndrome: A Systematic Review

Potential Protective Effect of Oleanolic Acid on the Components of Metabolic Syndrome: A Systematic Review

Long-Term Impact of Neonatal Intake of Oleanolic Acid on the Expression of AMP-Activated Protein Kinase, Adiponectin and Inflammatory Cytokines in Rats Fed with a High Fructose Diet

Prophylactic Use of Natural Products against Developmentally Programmed Metabolic Syndrome

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