The protective effect of Myrtus communis L. against experimental kidney stone in rats

Yılmaz, Halil; Ekinci, Nihat; Ömerli, Ayşe; Nisari, Mehtap; Yay, Arzu Hanım; Ülger, Harun; Karatoprak, Gökçe Şeker; Yılmaz, Seher; Ateş, Şükrü; Taştan, Mustafa

doi:10.1007/s13596-021-00620-4

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Here, twenty-seven plants with renal proficiency viz., Sida rhombifolia (10), Apium leptophyllum (11), Aconitum heterophyllum (12), Abies webbiana (13), Artocarpus hirsutus (14), Paederia foetida (15), Cocculus pendulus (16), Alangium salvifolium (17), Ruta graveolens (18), Calophyllum inophyllum (19), Rubia cordifolia (20), Myrtus communis (21), Pongamia pinnata (22), Convallaria majalis (23), Saussurea costus (24), Mimusops elengi (25), Calendula officinalis (26), Ficus bengalensis (27), Hypericum mysorense (28), Toona sinensis (29), Nelumbo nucifera (30), Chelidonium majus (31), Eclipta alba (32), Alstonia scholaris (33), Pterocarpus marsupium (34), Centella asiatica (35), and Plumbago zeylanica (36) have been chosen to screen their inhibitory binding efficacy with the efflux transporter by molecular docking. This study will help in the identification of reno-protective natural compounds as p-glycoprotein inhibitors, which in addition possess the ability to enhance the absorption of renal treatment substrate drugs inside the efflux-prone target cell.…”

Section: Introductionmentioning

confidence: 99%

Co-administration of herbal inhibitors of P-glycoprotein with renal drugs enhance their bioavailability– In silico approach

Roy

Ghosh

2023

J Herbmed Pharmacol

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Introduction: Multidrug resistance (MDR) is primarily associated with reduced intracellular drug accumulation owing to overexpression of p-glycoprotein, an active efflux transporter. Competitive inhibition or allosteric modulation of p-glycoprotein may alter the pharmacokinetics of the drugs that serve as substrates, resulting in enhanced drug bioavailability and tissue penetration. This study endeavors to assess the efficacy of the components of reno-protective herbs in the inhibition of p-glycoprotein activity thereby enhancing the possibility of the retention of co-administered renal medications inside the target cells. Methods: Drug-likeness and pharmacokinetic properties were determined to ensure the safety and efficacy of herbal constituents. Molecular docking employing the CDOCKER module of Discovery Studio was performed to investigate the binding affinity between the active constituents and the p-glycoprotein receptor (6C0V). Molecular dynamics simulation was utilized to further assess the stability of the complex of receptors with the component bearing its maximal affinity. Results: The analyses suggested that the inhibitors viz., atisine, kutkin, and embelin from Aconitum heterophyllum, phylloquinone from Calendula officinalis, stigmasterol from Paederia foetida, and convallamarogenin from Convallaria majalis demonstrated maximum binding affinity towards p-glycoprotein. Conclusion: Atisine may thus be identified as the lead compound in the augmentation of drug bioavailability inside the cell, along with its reno-protective efficacy.

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Section: Introductionmentioning

confidence: 99%

Co-administration of herbal inhibitors of P-glycoprotein with renal drugs enhance their bioavailability– In silico approach

Roy

Ghosh

2023

J Herbmed Pharmacol

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Preventive and therapeutic effects of Aerva lanata (L.) extract on ethylene glycol-induced nephrolithiasis in male Wistar albino rats

Chitra

Krishna

2022

Digital Chinese Medicine

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Could juice from Viburnum opulus potentially prevent the formation of kidney stones? (an anımal study)

Ömerli,

Ulger,

Nisari

et al. 2023

NRFHH

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The principal objective of this inquiry was to explore the potential impact of Viburnum opulus L. fruit juice in mitigating the occurrence of kidney stone formation within a rat model induced experimentally to develop kidney stones. Twenty Sprague Dawley rats were used in the study. They were placed in metabolic cages, with one rat per cage. Urine samples were collected every day during the study period. Biochemıcal values were measured in urine and blood. The rats were sacrificed, and their kidneys were removed and evaluated histopathologically after staining with Hematoxylin-Eosin (HE) and Pizzolato's (PZ) staining methods. The biochemical parameters observed in the urine samples collected from the experimental group of rats exhibited more excellent proximity to the negative control group's corresponding values than those of the positive control group. Upon microscopic examination of histological sections, a notable resemblance in histological architecture was discerned between the experimental and negative control groups. Additionally, a reduction in the incidence of stone formation was observed in the experimental group when contrasted with the positive control group. In light of the outcomes elucidated herein, it can be deduced that the administration of Viburnum opulus (VO) water engenders an augmenting impact on citrate levels. This elevation in citrate concentration holds potential significance as it demonstrates the potential to curtail crystal formation. Notably, citrate ions exhibit an inhibitory role in the genesis of calcium oxalate (CaOx) crystals, thereby contributing to the prevention.

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The protective effect of Myrtus communis L. against experimental kidney stone in rats

Cited by 3 publications

References 36 publications

Co-administration of herbal inhibitors of P-glycoprotein with renal drugs enhance their bioavailability– In silico approach

Co-administration of herbal inhibitors of P-glycoprotein with renal drugs enhance their bioavailability– In silico approach

Preventive and therapeutic effects of Aerva lanata (L.) extract on ethylene glycol-induced nephrolithiasis in male Wistar albino rats

Could juice from <i>Viburnum opulus</i> potentially prevent the formation of kidney stones? (an anımal study)

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