The protective effect of montelukast sodium on carbon tetrachloride induced hepatopathy in rat

Cuciureanu, Magdalena; Căruntu, Irina-Draga; O, Păduraru; Stoica, Bogdan; Jerca, L; Crauciuc, Eduard; Nechifor, M

doi:10.1016/j.prostaglandins.2008.10.004

Cited by 31 publications

(26 citation statements)

References 39 publications

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“…Protection of the liver from chemical injuries was produced by different agents such as herbs as it was reported by many authors who found that if the rats pre-treated with some herbal extracts against CCL4 or paracetamol instead of camel's milk and urine against ethanol 10%, that will significantly controlled the changes in the biochemical parameters, and exhibited a sharp decrease of the levels in the serum enzymes indicators of suffering liver [25]- [30]. Also similar results obtained by using montelukast sodium (Cysteinyl-leukotriene type 1 selective receptor antagonist) as hepatoprotective instead of camel's milk and urine [31].…”

Section: Discussionmentioning

confidence: 80%

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

Elhag¹,

Bernard²,

Badwi³

2017

ABB

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This study was implemented at the University of Khartoum to investigate the protective effect of camel milk mixed with camel urine against alcohol-induced liver damage in Wistar albino rats. The reasons for combining camel milk and urine together are because that in Sudan this combination is used extensively in traditional medicine and they claimed that this combination cures a lot of diseases including liver disease and jaundice; 25 Wister Albino rats of both sexes were brought and divided into 5 groups. Group 1 (control group) received normal saline, group 2 received ethanol 10% at dose of (0.5 g/100g body weight) and group 3 rats received Silymarin (5 mg/100g body weight) plus ethanol 10% (0.5 g/100g). Group 4 received a mixture of camel milk and urine (1:1) at the rate of 2 ml/100g and group 5 rats were administered with the mixture of camel's milk and urine as in group 4 plus ethanol 10% (0.5 g/100g). All treatments given by an oral intubation, experiment lasts for 28 days, rats were euthanized, serum samples and liver sections obtained. Oral administration of 10% ethanol (0.5 g/100g) induced liver damage which was clear in group 2 in a form of generalized necrosis, fatty change and congestion, beside high elevation of serum enzymes (AST, ALT, and ALP). Giving camel's milk and urine mixture to group 5 with ethanol 10% (0.5 g/100g), resulted in significant reduction of levels of serum enzymes (AST, ALT, and ALP) and in stabilization of serum metabolites (total protein, albumin and bilirubin). The degree of reduction was lower when significantly compared to (Silymarin + ethanol) group, and all results were verified by the histopathological changes. Hepatoprotective effects of camel's milk and urine mixture were recorded and this could be attributed to antioxidant activity or to its chelate effects on toxicants. Drinking raw camel milk and urine mixture,

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Section: Discussionmentioning

confidence: 80%

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

Elhag¹,

Bernard²,

Badwi³

2017

ABB

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“…Numerous studies have shown that montelukast possesses considerable antioxidant and anti-inflammatory functions (16,25). Protective effects of montelukast against oxidative stress have been attributed to a neutrophildependent pathway, ROS scavenging properties and inhibition of caspase 3 (14,26,27).…”

Section: Discussionmentioning

confidence: 99%

“…They play critical roles in bronchoconstriction, airflow obstruction, edema, and bronchial asthma (16,17). Many studies have demonstrated that anti-leukotriene agents possess ROS scavenging properties (18).…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of the Ameliorative Effect of Montelukast Against Arsenic Trioxide-Induced Cardiotoxicity in Rats

Hemmati

Olapour

Varzi

et al. 2017

Jundishapur J Nat Pharm Prod

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Background: Arsenic trioxide (As2O3) is used for treating patients with acute promyelocytic leukemia (APL). The extensive application of this drug has been limited due to its severe cardiotoxicity. Montelukast is a selective leukotriene receptor antagonist with antioxidant and anti-inflammatory properties. Objectives: This study evaluated whether montelukast could protect against As2O3-induced cardiotoxicity in vivo. Methods: Thirty-two male Wistar rats (150 to 200 g) were divided to 4 treatment groups: control (0.2 mL of saline, ip), As2O3 (5 mg/kg, ip), As2O3 plus MONT, and MONT (20 mg/kg, po). All drugs were administered daily for 10 days and pretreatment with MONT was performed 1 hour prior to As2O3 administration. Cardiotoxicity was estimated by electrocardiological, biochemical, and histopathological evaluations. Results:The results indicated that the combination treatment of montelukast and As2O3 markedly (P < 0.05) inhibited As2O3-induced lipid peroxidation and attenuated QT interval (QT) prolongation and histopathological alterations. Pretreatment with montelukast also suppressed increased troponin I and creatinine kinase-muscle brain (CK-MB) isoenzyme levels in response to As2O3 (P < 0.01). Conclusions:In conclusion, the current results demonstrated that montelukast possesses beneficial cardio-protective properties against As2O3 toxicity. It was also proposed that these protective effects were mediated by antioxidant modifications of montelukast.

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“…Several studies also showed that ML has a significant antioxidative effect on inhibition of lipid peroxidation in some tissues such as testis and liver 9,10 . Cuciureanu et al 11 demonstrated a partial hepatoprotective effect of montelukast against carbon tetrachloride induced hepatopathy on rats. However, there is no study on the therapeutic effect of this agent on over and uterus for oxidative damage caused by TCDD toxicity.…”

Section: Montelukast (Ml) Is An Anti-inflammatory Drugmentioning

confidence: 99%

The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats

et al. 2016

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PURPOSE:To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS:Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed. RESULTS:The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment. CONCLUSION:The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.

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The protective effect of montelukast sodium on carbon tetrachloride induced hepatopathy in rat

Cited by 31 publications

References 39 publications

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

The Evaluation of the Ameliorative Effect of Montelukast Against Arsenic Trioxide-Induced Cardiotoxicity in Rats

The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats

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The protective effect of montelukast sodium on carbon tetrachloride induced hepatopathy in rat

Cited by 31 publications

References 39 publications

Protective Activity of Camel’s Milk and Urine Mixture (&lt;i&gt;Camelus dromedaries&lt;/i&gt;) against Ethanol-Induced Hepatotoxicity in Rats

Protective Activity of Camel’s Milk and Urine Mixture (&lt;i&gt;Camelus dromedaries&lt;/i&gt;) against Ethanol-Induced Hepatotoxicity in Rats

The Evaluation of the Ameliorative Effect of Montelukast Against Arsenic Trioxide-Induced Cardiotoxicity in Rats

The beneficial effects of Montelukast against 2,3,7,8-tetrachlorodibenzo- p -dioxin toxicity in female reproductive system in rats

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Product

Resources

About

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats

Protective Activity of Camel’s Milk and Urine Mixture (<i>Camelus dromedaries</i>) against Ethanol-Induced Hepatotoxicity in Rats