The protective effect of Malva sylvestris on rat kidney damaged by vanadium

Abstract

BackgroundThe protective effect of the common mallow (Malva sylvestris) decoction on renal damages in rats induced by ammonium metavanadate poisoning was evaluated. On the one hand, vanadium toxicity is associated to the production of reactive oxygen species, causing a lipid peroxidation and an alteration in the enzymatic antioxidant defence. On the other hand, many medicinal plants are known to possess antioxidant and radical scavenging properties, thanks to the presence of flavonoids. These properties were confirmed in Malva sylvestris by two separate methods; namely, the Diphenyl-2-picrylhydrazyl assay and the Nitroblue Tetrazolium reduction assay.ResultsIn 80 rats exposed to ammonium metavanadate (0.24 mmol/kg body weight in drinking water) for 90 days, lipid peroxidation levels and superoxide dismutase, catalase and glutathione peroxidase activities were measured in kidney. A significant increase in the formation of free radicals and antioxidant enzyme activities was noticed. In addition, a histological examination of kidney revealed a structural deterioration of the renal cortical capsules and a shrinking of the Bowman space. In animals intoxicated by metavanadate but also given a Malva sylvestris decoction (0.2 g dry mallow/kg body weight), no such pathologic features were observed: lipid peroxidation levels, antioxidant enzyme activities and histological features appeared normal as compared to control rats.ConclusionMalva sylvestris is proved to have a high antioxidative potential thanks to its richness in phenolic compounds.

Malva species: Insights on its chemical composition towards pharmacological applications

“…A considerable protective effect of plant extract was found against lithium‐induced toxicity in both organs associated with the existence of complex polysaccharides (Saad et al, ). According to the report by Marouane et al, the administration of M. sylvestris extract also could decrease lipids peroxidation levels and superoxide dismutase, CAT and glutathione peroxidase activities in the abnormal features observed in kidney slices from vanadium‐poisoned rats in rat kidney, which had already enhanced by vanadium treatment (Marouane, Soussi, Murat, Bezzine, & El Feki, ). Jabri et al have studied the protective effect of M. sylvestris aqueous extract against oxidative stress induced by loperamide in rat jejunum.…”

Hepatoprotective effects of Malva sylvestris L. against paracetamol-induced hepatotoxicity

“…Malva sylvestris is rich in phytoconstituents (Nehir and Karakaya, 2004;Wang, 2005;Barros et al, 2010;Çadırcı et al, 2012;Sabri et al, 2012;Tabaraki et al, 2012). It has shown potential therapeutic effects against various diseases (Jan et al, 2009;Pirbalouti et al, 2009;Marouane et al, 2011;Razavi et al, 2011). Diabetes mellitus, being an autoimmune syndrome, is among the major life-threatening diseases (Akash et al, , 2013a(Akash et al, , 2013b.…”

A Coordination Chemistry Study of Hydrated and Solvated Cationic Vanadium Ions in Oxidation States +III, +IV, and +V in Solution and Solid State

“…13–19 Vanadium toxicity is often associated to the production of reactive oxygen species, causing a lipid peroxidation and an alteration in the enzymatic antioxidant defence. 20 The coordination chemistry and role of vanadium in biological systems have been reviewed in many publications and books. 1,5–10,21–23 Vanadium compounds have received increased attention as catalysts in a number of applications as recently reviewed.…”