The protective effect of lycopene against oxidative kidney damage associated with combined use of isoniazid and rifampicin in rats

Abstract

It is known that the combined use of antibiotics, such as isoniazid and rifampicin, in the treatment of tuberculosis causes oxidative kidney damage. The aim of this study was to biochemically and histopathologically investigate the effect of lycopene on oxidative kidney damage due to the administration of isoniazid and rifampicin in albino Wistar male rats. Lycopene at a dose of 5 mg/kg was orally administered to lycopene+isoniazid+rifampicin (LIR) rats, and normal sunflower oil (0.5 mL) was orally administered to isoniazid+rifampicin (IR) and healthy control (HG) rats as vehicle by gavage. One hour after the administration of lycopene and vehicle, 50 mg/kg isoniazid and rifampicin were given orally to the LIR and IR groups. This procedure was performed once a day for 28 days. Rats were sacrificed by a high dose of anesthesia at the end of this period, and oxidantantioxidant parameters were measured in the removed kidney tissues. Creatinine and blood urea nitrogen (BUN) levels were measured in blood samples, and kidney tissues were also evaluated histopathologically. The combined administration of isoniazid and rifampicin changed the oxidant-antioxidant balance in favor of oxidants, and it increased blood urea nitrogen and creatinine levels, which are indicators of kidney function. Co-administration of isoniazid and rifampicin also caused oxidative kidney damage. Lycopene biochemically and histopathologically decreased oxidative kidney damage induced by isoniazid and rifampicin administration. These results suggested that lycopene may be beneficial in the treatment of nephrotoxicity due to isoniazid and rifampicin administration.

Endogenous and Exogenous Antioxidants as Agents Preventing the Negative Effects of Contrast Media (Contrast-Induced Nephropathy)

“…Lycopene positive on animal models [200,[209][210][211] Green tea extract positive on animal models [219,220] GSPE positive on animal models [224,225] Curcumin positive on animal models [228,229] Xylose-pyrogallol conjugate positive on animal models [231]…”

“…Lycopene is a carotenoid with antioxidant properties (Figure 13) found in tomato and other red fruits and vegetables [208]. Lycopene was shown to be protective in oxidation of lipids, proteins and DNA in vivo and to exhibit protective effects against different nephrotoxic agents [209,210]. Lycopene exhibited anti-inflammatory, antiautophagic and antiapoptotic properties in an experimental model of CIN in rats [211].…”

Therapeutic Effect of Natural Products and Dietary Supplements on Aflatoxin-Induced Nephropathy

“…Lycopene is a naturally occurring carotenoid that can be found in tomatoes, watermelon and other foods [ 146 , 147 , 148 ]. It has a wide range of biological activities, including protection against cancer, oxidation, aging, and inflammation [ 149 , 150 , 151 ]. Lycopene is an effective antioxidant and has a high potential for scavenging free radicals [ 152 ].…”

Lycopene: A Potent Antioxidant with Multiple Health Benefits

“…As a result, the utilisation of antioxidant therapy is one of the significant approaches to avert and mitigate the advancement of CKD [ 56 ]. Lycopene is a potent antioxidant and an efficient free radical scavenger that has been investigated and shown to protect the kidney against chemically induced damage [ 125 , 126 ]. In female Wistar rats fed a high-fat diet, the supplementation of 200 ml of lycopene extract twice a week for 8 weeks significantly reduced plasma creatinine, urea, serum angiotensin-converting enzymes, renal tissue malondialdehyde, and C-reactive protein levels but increased total protein and tissue antioxidant enzyme levels [ 127 ].…”