The Protective Effect of Lycium Ruthenicum Murr Anthocyanins in Cr (VI)-Induced Mitophagy in DF-1 Cells

Guo, Shuai; Qi, Mengzhu; Li, Hongyan; Cui, Yukun; Qi, Changxi; Cheng, Guodong; Lv, Meiyun; Zheng, Pimiao; Liu, Jianzhu

doi:10.3390/life12081115

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…Tomato anthocyanin ameliorates Cr(VI)-induced autophagy by inhibiting ER stress (Liu et al, 2020). Lycium ruthenicum Murr anthocyanin can inhibit autophagic activity and reduce mitochondrial damage through downregulation of the PINK1/Parkin pathway, resulting in a protective effect on DF-1 cells (Guo et al, 2022), Platycodon grandiflorus polysaccharides could improve Cr(VI)-induced mitochondrial autophagy by inhibiting ROS and restoring MMP (Hao et al, 2020). These studies could serve as bases for the treatment of Cr poisoning.…”

Section: Detoxifying Substancesmentioning

confidence: 95%

Toxicity mechanisms and remediation strategies for chromium exposure in the environment

Yan

Ying-jun

Xue

et al. 2023

Front. Environ. Sci.

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Chromium (Cr) is the seventh most abundant chemical element in the Earth’s crust, and Cr(III) and Cr(VI) are common stable valence states of Cr. Several Cr-containing substances, such as FeOCr2O3 and stainless-steel products, exist in nature and in life. However, Cr(VI) is toxic to soil, microorganisms, and plants and poses a serious threat to human health through direct and indirect exposure. By collecting published journal literature, we found that Cr(VI) can cause acute and chronic toxicity in organisms and has carcinogenic effects, and the mechanisms causing these toxicity include endoplasmic reticulum stress, autophagy and apoptosis. However, the relationship between these mechanisms remains unclear. Many methods have been researched to purify chromium, but each of these methods has its own advantages and disadvantages. Therefore, this review summarizes the hazards of chromium and the mechanisms of chromium toxicity after entering cells and provides a number of methods for chromium contamination management, providing a direction for the next step in chromium toxicology and contamination decontamination research.

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Section: Detoxifying Substancesmentioning

confidence: 95%

Toxicity mechanisms and remediation strategies for chromium exposure in the environment

Yan

Ying-jun

Xue

et al. 2023

Front. Environ. Sci.

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“…Li L. et al [71] investigated the mechanism of LRM anthocyanins in treating gouty arthritis, identifying potential targets and pathways through tissue lipidomics, cyberpharmacology, and molecular docking. Guo S. et al [72] demonstrated that LRM anthocyanins mitigate mitochondrial damage and autophagy induced by chromium (VI) in cells, suggesting protective effects against heavy metal toxicity.…”

Section: Other Bioactivitiesmentioning

confidence: 99%

Research Progress on Active Ingredients and Product Development of Lycium ruthenicum Murray

Xu,

He,

Xie

et al. 2024

Molecules

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Lycium ruthenicum Murray possesses significant applications in both food and medicine, including antioxidative, anti-tumor, anti-fatigue, anti-inflammatory, and various other effects. Consequently, there has been a surge in research endeavors dedicated to exploring its potential benefits, necessitating the organization and synthesis of these findings. This article systematically reviews the extraction and content determination methods of active substances such as polysaccharides, anthocyanins, flavonoids, and polyphenols in LRM in the past five years, as well as some active ingredient composition determination methods, biological activities, and product development. This review is divided into three main parts: extraction and determination methods, their bioactivity, and product development. Building upon prior research, we also delve into the economic and medicinal value of Lycium ruthenicum Murray, thereby contributing significantly to its further exploration and development. It is anticipated that this comprehensive review will serve as a valuable resource for advancing research on Lycium ruthenicum Murray.

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“…Similarly, Lycium Ruthenicum Murr anthocyanins (LRMA) have also been shown to inhibit autophagy and mitophagy in DF‐1 cells that were administrated with Cr (VI). These effects could be attributed to the fact that LRMA reduced oxidative stress and inhibited the putative protein kinase 1 (PINK1)/Parkin pathway (Guo et al., 2022). Accordingly, Wistar rats were applied to demonstrate that anthocyanins mitigated the adverse effects of Cr (VI) on the adrenal gland.…”

Section: Influence Of Anthocyanins On Food Contaminants From the Natu...mentioning

confidence: 99%

Mechanism of action of anthocyanin on the detoxification of foodborne contaminants—A review of recent literature

Jiang,

Li,

Zhang

et al. 2023

Comp Rev Food Sci Food Safe

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Foodborne contaminants refer to substances that are present in food and threaten food safety. Due to the progress in detection technology and the rising concerns regarding public health, there has been a surge in research focusing on the dangers posed by foodborne contaminants. These studies aim to explore and implement strategies that are both safe and efficient in mitigating the associated risks. Anthocyanins, a class of flavonoids, are abundantly present in various plant species, such as blueberries, grapes, purple sweet potatoes, cherries, mulberries, and others. Numerous epidemiological and nutritional intervention studies have provided evidence indicating that the consumption of anthocyanins through dietary intake offers a range of protective effects against the detrimental impact of foodborne contaminants. The present study aims to differentiate between two distinct subclasses of foodborne contaminants: those that are generated during the processing of food and those that originate from the surrounding environment. Furthermore, the impact of anthocyanins on foodborne contaminants was also summarized based on a review of articles published within the last 10 years. However, further investigation is warranted regarding the mechanism by which anthocyanins target foodborne contaminants, as well as the potential impact of individual variations in response. Additionally, it is important to note that there is currently a dearth of clinical research examining the efficacy of anthocyanins as an intervention for mitigating the effects of foodborne pollutants. Thus, by exploring the detoxification effect and mechanism of anthocyanins on foodborne pollutants, this review thereby provides evidence, supporting the utilization of anthocyanin‐rich diets as a means to mitigate the detrimental effects of foodborne contaminants.

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The Protective Effect of Lycium Ruthenicum Murr Anthocyanins in Cr (VI)-Induced Mitophagy in DF-1 Cells

Cited by 3 publications

References 37 publications

Toxicity mechanisms and remediation strategies for chromium exposure in the environment

Toxicity mechanisms and remediation strategies for chromium exposure in the environment

Research Progress on Active Ingredients and Product Development of Lycium ruthenicum Murray

Mechanism of action of anthocyanin on the detoxification of foodborne contaminants—A review of recent literature

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