The Protective Effect of L-arginine in Cisplatin-induced Nephrotoxicity in Streptozotocin-induced Diabetic Rats

Gharibi, Fatemeh; Soltani, Nepton; Maleki, Maryam; Talebi, Ardeshir; Nasiri, Masoumeh; Shirdavani, Soheyla; Nematbakhsh, Mehdi

doi:10.4103/2277-9175.212928

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…24 The positive effects of arginine on oxidative stress have also been studied by Gharibi et al, who reported that L-arginine supplementation increased NO concentration and significantly improved oxidative status. 16 In our study, histological examination of the kidneys showed clear evidence of cisplatin-induced nephrotoxic injury manifested as marked tubular cell necrosis, vascular congestion, and tubular dilatation, which is consistent with previous findings. 3 However, these changes were much less evident in the arginine treated animals.…”

Section: Discussionsupporting

confidence: 93%

“…15 Cisplatin has been proven to be toxic to kidneys causing alterations in the parameters of renal function. 16 Cisplatin has also been shown to have a direct inflammatory effect on the kidneys as well as causing increased oxidative stress leading to depletion of vital anti-oxidant molecules like glutathione. 17 In our experiment, administration of cisplatin was followed by a reduction in the weight of the experimental animals, which is consistent with previous findings.…”

Section: Discussionmentioning

confidence: 99%

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Nephroprotective Effects of L-Arginine against Chemotherapy Induced Acute Kidney Injury in Wistar Rats

Meghji

Memon

Ahmed³

et al. 2020

J Islamabad Med Dental Coll

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Objective To evaluate the protective role of L-Arginine in cisplatin induced acute renal injury through assessment of renal, oxidative stress and inflammatory markers in albino wistar rats. Methods: Quasi-experimental study was conducted at the department of physiology and postgraduate research laboratory at Isra University, Hyderabad, Sindh from April 2019 to September 2019. Thirty male Albino wistar rats were selected through non-random purposive sampling and divided equally into three different groups: Group-A (Control group), Group-B (experimental group) received Cisplatin alone and Group-C (experimental group) received Cisplatin along with arginine. After sacrificing the animals, blood samples were collected through cardiac puncture while renal histopathological analysis was under the light microscope. The changes in severity were observed using a graded scale. Data was analysed using SPSS v23.0. Results: There was a statistically significant (p-value <0.05) decline in the bodyweight and rise in absolute kidney weight of group B in comparison with other two group. Moreover, significant rise (p-value <0.05) in serum renal markers was observed in group B while significant decline (p-value <0.05) in these serum renal markers in group C compared with group B. Furthermore, prominent demage in normal renal histology in group B rats while restoration of renal histology was demonstrated in group C rats. Conclusion: The present study concludes that L-Arginine exerts an anti-oxidative, anti-inflammatory and nephro-protective effect for renal tissue damage caused by Cisplatin. Keywords: Acute Kidney Injury, Antioxidant, Cisplatin, L-Arginine, Oxidative stress

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Nephroprotective Effects of L-Arginine against Chemotherapy Induced Acute Kidney Injury in Wistar Rats

Meghji

Memon

Ahmed³

et al. 2020

J Islamabad Med Dental Coll

View full text Add to dashboard Cite

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“…For antidiabetic activity, six animals in each group were taken, Group-I rats were assigned as a normal control (NC) group and received olive oil and water (1:1) orally, Group-II considered as diabetic control (DC) also received olive oil and water (1:1) orally, Group-III assigned as Standard control (STD) received Metformin (150 mg/kg) orally, (AbdRaboh & Ahmed, 2015) Group-IV (BCP) received BCP in olive oil (200 mg/kg) (Basha & Sankaranarayanan, 2016) orally, Group-V (LA) (Nematbakhsh et al, 2017) received LA (150 mg/kg) in water orally, Group-VI (COM) received both BCP (200 mg/kg), and LA (150 mg/kg) orally in an interval of 15 min. The treatment was given to diabetic animals daily for 42 days.…”

Section: Treatmentmentioning

confidence: 99%

Insulinotropic and antidiabetic effects of β‐caryophyllene with l ‐arginine in type 2 diabetic rats

Kumawat

Kaur

2020

J Food Biochem

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Beta‐caryophyllene (BCP) is a flavoring agent, whereas l‐arginine (LA) is used as a food supplement. They possess insulinotropic and β cell regeneration activities, respectively. We assessed the antidiabetic potential of BCP, LA, and its combination in RIN‐5F cell lines and diabetic rats. Ex vivo studies were carried out for glucose uptake and absorption of the combination of BCP with LA. The results indicated that the combination of BCP with LA showed a significant decrease in glucose absorption and an increase in its uptake in tissues and also an increase in insulin secretion in RIN‐5F cells. The combination treatment of BCP with LA showed a significant reduction in glucose, lipid levels, and oxidative stress in pancreatic tissue when compared with the diabetic group. Furthermore, the combination of BCP with LA normalized glucose tolerance and pancreatic cell damage in diabetic rats. In conclusion, the combinational treatment showed significant potentials in the treatment of type 2 diabetes mellitus. Practical applications Type 2 diabetes mellitus is the most prevalent chronic metabolic disorder affecting a large population. Beta‐caryophyllene is a CB2 receptor agonist shown to have insulinotropic activity. l‐Arginine is a food supplement that possesses beta‐cell regeneration property. The combination of BCP with LA could work as a potential therapeutic intervention, considering the individual pharmacological activities of each. We evaluated the antidiabetic activity of the combination of BCP with LA in diabetic rats using ex vivo and in vitro experimentations. Results from the study revealed that the combination of BCP with LA showed a significant (p < .001) reduction in glucose and lipid levels as compared to individual treatment. In vitro study also supports the diabetic potential of the combination of BCP with LA in the glucose‐induced insulin secretion in RIN‐5F cell lines. The study indicates a therapeutic approach to treat T2DM by BCP and LA combination as food and dietary supplement.

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“…The DM group rats were found to have the lightest weight, in spite of their high food and water intake. Since STZ causes β cell necrosis and disrupts insulin synthesis, it will induce high blood sugar levels in rats ( Islam and Loots du, 2009 , Zou et al, 2017 , Gharibi et al, 2017 ). The DM rats exhibited high blood sugar, TG, and cholesterol levels, as well as significantly higher concentrations of serum GOT and GTP compared to the CT group- an indicator of impaired liver function.…”

Section: Discussionmentioning

confidence: 99%

A metabolomics approach to investigate the proceedings of mitochondrial dysfunction in rats from prediabetes to diabetes

Huang

Chen

Lin

et al. 2021

Saudi Journal of Biological Sciences

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Background Diabetes mellitus (DM) is a leading cause of preventable cardiovascular disease, but the metabolic changes from prediabetes to diabetes have not been fully clarified. This study implemented a metabolomics profiling platform to investigate the variations of metabolites and to elucidate their global profiling from metabolic syndrome to DM. Methods: Male Sprague-Dawley rats (n = 44) were divided into four groups. Three groups were separately fed with a normal diet, a high-fructose diet (HF), or a high-fat (HL) diet while one group was treated with streptozotocin. The HF and HL diet were meant to induce insulin resistance, obesity, and dyslipidemia, which known to induce DM. Results: The most significant metabolic variations in the DM group’s urine samples were the reduced release of citric acid cycle intermediates, the increase in acylcarnitines, and the decrease in urea excretion, all of which indicated energy metabolism abnormalities and mitochondrial dysfunction. Overall, the metabolic analysis revealed tryptophan metabolic pathway variations in the prediabetic phase, even though the mitochondrial function remains unaffected. Conclusion: This study show that widespread methylations and impaired tryptophan metabolism occur in metabolic syndrome and are then followed by a decline in citric acid cycle intermediates, indicating mitochondrial dysfunction in diabetes.

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The Protective Effect of L-arginine in Cisplatin-induced Nephrotoxicity in Streptozotocin-induced Diabetic Rats

Cited by 6 publications

References 35 publications

Nephroprotective Effects of L-Arginine against Chemotherapy Induced Acute Kidney Injury in Wistar Rats

Nephroprotective Effects of L-Arginine against Chemotherapy Induced Acute Kidney Injury in Wistar Rats

Insulinotropic and antidiabetic effects of β‐caryophyllene with l ‐arginine in type 2 diabetic rats

A metabolomics approach to investigate the proceedings of mitochondrial dysfunction in rats from prediabetes to diabetes

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