The protective effect of isoflurane pretreatment on liver IRI by suppressing noncanonical pyroptosis of liver macrophages

Lu, Jiao; Wang, Xiaoying; Feng, Zhihao; Chen, Yu‐Cheng; Wen, Diguang; Liu, Zuojin

doi:10.1016/j.intimp.2021.107977

Cited by 8 publications

(4 citation statements)

References 36 publications

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“…Iisoflurane pretreatment also inhibited caspase-11 expression and noncanonical pyroptosis-related production of cytokines (IL-1beta and IL-18). These findings suggest that isoflurane could be a pharmacological agent for liver IRI prevention and thus deserves more attention and further investigation (71).…”

Section: The Nlrp3 Activation Of Liver Macrophages In Lirimentioning

confidence: 88%

The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury

Zhang

Shao

et al. 2022

Front. Immunol.

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Ischemia-reperfusion injury (IRI) is considered an inherent component involved in liver transplantation, which induce early organ dysfunction and failure. And the accumulating evidences indicate that the activation of host innate immune system, especially hepatic macrophages, play a pivotal role in the progression of LIRI. Inflammasomes is a kind of intracellular multimolecular complexes that actively participate in the innate immune responses and proinflammatory signaling pathways. Among them, NLRP3 inflammasome is the best characterized and correspond to regulate caspase-1 activation and the secretion of proinflammatory cytokines in response to various pathogen-derived as well as danger-associated signals. Additionally, NLRP3 is highly expressed in hepatic macrophages, and the assembly of NLRP3 inflammasome could lead to LIRI, which makes it a promising therapeutic target. However, detailed mechanisms about NLRP3 inflammasome involving in the hepatic macrophages-related LIRI is rarely summarized. Here, we review the potential role of the NLRP3 inflammasome pathway of hepatic macrophages in LIRI, with highlights on currently available therapeutic options.

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Section: The Nlrp3 Activation Of Liver Macrophages In Lirimentioning

confidence: 88%

The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury

Zhang

Shao

et al. 2022

Front. Immunol.

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“…Numerous studies on the role of macrophage pyroptosis in liver disease have been reported by researchers, which have been summarized in Table 1 . Notably, macrophage pyroptosis plays a crucial role in various liver diseases ( 58 ).…”

Section: The Role Of Macrophage Pyroptosis In Liver Diseasesmentioning

confidence: 99%

“…This implies the involvement of non-canonical pyroptosis in the macrophage-driven hepatic IRI. Isoflurane intervention curbs this pyroptosis by inhibiting intracellular Ca 2+ levels, NF-κB translocation, NLPR3 inflammasome activation, and the caspase-11-mediated non-canonical pyroptosis pathway ( 58 ). The downregulation of ApoA-1 during IRI after liver transplantation increases pyroptosis (but not apoptosis) in liver macrophages.…”

Section: The Role Of Macrophage Pyroptosis In Liver Diseasesmentioning

confidence: 99%

Unveiling the flames: macrophage pyroptosis and its crucial role in liver diseases

Ni,

Chen,

Zhao

et al. 2024

Front. Immunol.

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Macrophages play a critical role in innate immunity, with approximately 90% of the total macrophage population in the human body residing in the liver. This population encompasses both resident and infiltrating macrophages. Recent studies highlight the pivotal role of liver macrophages in various aspects such as liver inflammation, regeneration, and immune regulation. A novel pro-inflammatory programmed cell death, pyroptosis, initially identified in macrophages, has garnered substantial attention since its discovery. Studies investigating pyroptosis and inflammation progression have particularly centered around macrophages. In liver diseases, pyroptosis plays an important role in driving the inflammatory response, facilitating the fibrotic process, and promoting tumor progression. Notably, the role of macrophage pyroptosis cannot be understated. This review primarily focuses on the role of macrophage pyroptosis in liver diseases. Additionally, it underscores the therapeutic potential inherent in targeting macrophage pyroptosis.

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“…However, a recent study by Khanova et al showed that pyroptosis in liver inflammation is induced by the noncanonical caspase-11 pathway, rather than caspase-1, and is a key mechanism driving the progression of ASH to AH (Khanova et al, 2018). Pyroptosis is also a vital feature of aseptic liver diseases, such as high fat diet-induced liver damage, polystyrene microplastics-induced liver injury, acetaminophen-induced liver damage, hepatic ischemia-reperfusion damage and cholestatic liver diseases (Zhang et al, 2021c;Lu et al, 2021;Wang et al, 2022b;Han et al, 2022;Mu et al, 2022). Taken together, identification of novel pyroptosis-related targets can provide new insights for the treatment of the above diseases.…”

Section: Pyroptosis In Liver Diseasesmentioning

confidence: 99%

The role of pyroptosis in inflammatory diseases

Chai

Liu

Shui

et al. 2023

Front. Cell Dev. Biol.

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Programmed cell death has crucial roles in the physiological maturation of an organism, the maintenance of metabolism, and disease progression. Pyroptosis, a form of programmed cell death which has recently received much attention, is closely related to inflammation and occurs via canonical, non-canonical, caspase-3-dependent, and unclassified pathways. The pore-forming gasdermin proteins mediate pyroptosis by promoting cell lysis, contributing to the outflow of large amounts of inflammatory cytokines and cellular contents. Although the inflammatory response is critical for the body’s defense against pathogens, uncontrolled inflammation can cause tissue damage and is a vital factor in the occurrence and progression of various diseases. In this review, we briefly summarize the major signaling pathways of pyroptosis and discuss current research on the pathological function of pyroptosis in autoinflammatory diseases and sterile inflammatory diseases.

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The protective effect of isoflurane pretreatment on liver IRI by suppressing noncanonical pyroptosis of liver macrophages

Cited by 8 publications

References 36 publications

The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury

The Role of NLRP3 Inflammasome Activation Pathway of Hepatic Macrophages in Liver Ischemia–Reperfusion Injury

Unveiling the flames: macrophage pyroptosis and its crucial role in liver diseases

The role of pyroptosis in inflammatory diseases

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