The protective effect of<i>Tinospora cordifolia</i>on various mast cell mediated allergic reactions

Zalawadia, Rishit; Gandhi, Chintan; Patel, Vaibhav B.; Balaraman, R

doi:10.3109/13880200903008690

Cited by 11 publications

(5 citation statements)

References 31 publications

(27 reference statements)

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“…In addition, TNF-α was inhibited by Tinospora cordifolia in dinitrophenyl (DNP) IgE-stimulated rat peritoneal mast cells. All these experiments conclude that Tinospora cordifolia, Rubia cordifolia might be having potent antiallergic components 27,28 .…”

Section: Tinospora Cordifolia Rubia Cordifoliamentioning

confidence: 78%

“…Therefore, there is a search for alternate form of therapy. Tinospora cordifolia, Rubia cordifolia were evaluated for their antiallergic activity in the experimentally induced allergic condition 27,28 . It was found that Tinospora cordifolia and Rubia cordifolia exhibited significant inhibition in vascular permeability, inhibition in histamine release from the rat conjunctiva.…”

Section: Tinospora Cordifolia Rubia Cordifoliamentioning

confidence: 99%

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A Review on the Biological Effects of some Natural Products

Balaraman¹,

Parmar²,

Maheshwari³

et al. 2020

Journal of Natural Remedies

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This review is a compilation of a number of preclinical studies of the natural products for their biological activities. Many natural products studied for their biological activities are either in the form of herbal formulations or plant extracts. They showed antihypertensive, antilipidemic, antidiabetic, antioxidant, antianxiety, hepatoprotective, and many other activities. Many post graduate and doctoral students took part in studying the biological activities of these natural products. This comprehensive review will give an impetus for young research workers to explore the possibility of more biological activities on these natural products for the future studies to combat diseases.

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Section: Tinospora Cordifolia Rubia Cordifoliamentioning

confidence: 78%

Section: Tinospora Cordifolia Rubia Cordifoliamentioning

confidence: 99%

A Review on the Biological Effects of some Natural Products

Balaraman¹,

Parmar²,

Maheshwari³

et al. 2020

Journal of Natural Remedies

View full text Add to dashboard Cite

show abstract

“…It also alleviates respiratory problems such as asthma, bronchitis, and coughs. It is thought to have bronchodilator and anti-asthmatic effects [ 18 , 19 ]. In Ayurveda, T. cordifolia is classified as an adaptogen, or Rasayana, which means it is believed to enhance vitality, reduce stress, and promote overall well-being.…”

Section: Ethnopharmacological Importance Of T Cordifoliamentioning

confidence: 99%

“…T. cordifolia is traditionally used for the treatment of asthma, and the juice is also used for the treatment of chronic coughs [ 141 ]. Aqueous extract of T. cordifolia reduces mast-mediated allergic reactions in rats via anti-histaminic activities [ 18 ]. Moreover, decreased symptoms of allergic rhinitis like sneezing, nasal discharge, nasal obstruction, and nasal pruritus were also reported [ 78 ].…”

Section: Pharmacological Activities Of T Cordifoliamentioning

confidence: 99%

Tinospora cordifolia (Giloy): An insight on the multifarious pharmacological paradigms of a most promising medicinal ayurvedic herb

Gupta,

Bajpai

2024

Heliyon

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“…According to the ED 50 of individual herbs, a Polyherbal Formulation (PHF) was developed. ED 50 of T. cardifolia (517.81 mg/kg) 13 , A. leucopholea (200 mg/kg). R. damascena (600 mg/kg) 14 .…”

Section: Preparation Of Poly-herbal Formulationmentioning

confidence: 99%

Evaluating the Efficacy of a Polyherbal Formulation in Ameliorating Arthritis Induced by Complete Freund’s Adjuvant

Chitra,

Damodharan,

Narasimha

et al. 2024

JNR

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Background: This study investigates the antiarthritic potential of a polyherbal formulation (PHF) comprising extracts from Tinospora cordifolia, Rosa damescena, and Acacia leucoploea in a rat model of rheumatoid arthritis (RA). RA is a chronic autoimmune disorder with debilitating consequences. PHF's impact on joint inflammation, bone degradation, and cartilage preservation were evaluated. Methods: Arthritis was induced using complete Freund’s adjuvant (CFA), and animals were treated with PHF (200 and 400 mg/kg), prednisolone, or control treatments for 28 days. Parameters including body weight, paw volume, arthritis severity score, hematological parameters, serum markers (creatinine, ALP, total proteins), cytokine levels (IL-1β, IL-6, TNF-α, IL-10), and radiographic changes were assessed. Results: CFA-treated rats exhibited significant body weight loss, paw edema, increased arthritis severity scores, altered hematological parameters, and elevated serum markers compared to normal controls. PHF treatment at both doses mitigated body weight loss, reduced paw edema, and improved arthritis severity scores. Hematological changes induced by CFA were also attenuated by PHF treatment. Serum creatinine, ALP, and total protein levels, elevated in CFA-treated rats, were significantly improved by PHF. Furthermore, PHF modulated cytokine levels, decreasing IL-6, IL-1β, and TNF-α while increasing IL-10. Radiographic analysis displayed reduced joint damage in PHF-treated rats compared to CFA controls. Conclusion: This comprehensive investigation highlights PHF's potential to mitigate the inflammatory processes associated with RA, as evidenced by improved clinical, hematological, and biochemical parameters. The study underscores the promise of traditional botanical compounds in managing RA and suggests PHFs as novel therapeutic options. Further mechanistic studies are warranted to elucidate the exact pathways involved.

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The protective effect ofTinospora cordifoliaon various mast cell mediated allergic reactions

Cited by 11 publications

References 31 publications

A Review on the Biological Effects of some Natural Products

A Review on the Biological Effects of some Natural Products

Tinospora cordifolia (Giloy): An insight on the multifarious pharmacological paradigms of a most promising medicinal ayurvedic herb

Evaluating the Efficacy of a Polyherbal Formulation in Ameliorating Arthritis Induced by Complete Freund’s Adjuvant

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