The protective effect of <i>Eruca sativa</i> against lipid metabolic abnormalities induced by dioxin in male rats

El-Gayar, Hussam A; Salem, Eman T.; Edrees, G.M.

doi:10.1080/2314808x.2022.2102772

Cited by 1 publication

(1 citation statement)

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“…Most of the diseases occurring world-wide are the result of a series of uncontrolled reactions initiated by a number of reactive species (ROS). To counteract the effect of these reactive species involved in different diseases, ER must be able to stabilize these and thus act as a successful antioxidant ( El-Gayar et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Development and optimization of nanoparticles loaded with erucin, a dietary isothiocyanate isolated from Eruca sativa: Antioxidant and antiproliferative activities in ehrlich-ascites carcinoma cell line

Singh

Attri

et al. 2023

Front. Pharmacol.

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The study on Erucin (ER) has gained interest of nutraceutical and pharmaceutical industries because of its anti-cancer properties. Erucin is an isothiocyanate obtained from the seeds of Eruca sativa which possess certain drawbacks such as poor aqueous solubility and bioavailability. Therefore, the present study aimed at developing ER-cubosomes (CUB) by solvent evaporation technique followed by applying Central Composite Design to optimize ER loaded cubosomes. For this purpose, independent variables selected were Monoolein (MO) as lipid and Pluronic-84 (P-84) as a stabilizer whereas dependent variables were particle size, percentage of ER loading and percentage of its entrapment efficiency. The cubosomal nanocarriers exhibited particle size in the range of 26 nm, entrapment efficiency of 99.12 ± 0.04% and drug loading of 3.96 ± 0.0001%. Furthermore, to investigate the antioxidant potential, we checked the effect of ER and ER-CUB by DNA nicking assay, DDPH assay and Phosphomolybdate assay, and results showed significant improvement in antioxidant potential for ER-CUB than ER. Similarly, ER-CUB showed enhanced anticancer activity with a marked reduction in IC50 value than ER in MTT assay. These results suggested that ER-CUB produced notable escalation in antioxidant potential and enhanced anticancer activity than ER.

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Section: Introductionmentioning

confidence: 99%