The protective effect of Ferula elaeochytris on age-related erectile dysfunction

Eser, Nadire; Yoldaş, Atila; Yiğin, Akın; Yumuşak, Nihat; Bozkurt, Ahmet Sarper; Kökbaş, Umut; Aslan, Mustafa

doi:10.1016/j.jep.2020.112921

Cited by 10 publications

(7 citation statements)

References 51 publications

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“…2000 years ago. However, currently there is a greater danger lurking around Ferula drudeana growing in Anatolia perpetrated by the onslaught of publications appearing in various journals that the Ferula species growing in Anatolia has aphrodisiac qualities [63] and can help people that have erectile dysfunction problems [171][172][173]. If short-term commercial exploitation is unchecked, the very large-scale destruction of their roots certainly will drive many endemic The impact of these negative ecological and man-made factors, in addition to the over harvesting of the silphion plant, driven by short-term profit, definitely contributed to the extinction of this species.…”

Section: Discussionmentioning

confidence: 99%

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Miski

2021

Plants

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Silphion was an ancient medicinal gum-resin; most likely obtained from a Ferula species growing in the Cyrene region of Libya ca. 2500 years ago. Due to its therapeutic properties and culinary value, silphion became the main economic commodity of the Cyrene region. It is generally believed that the source of silphion became extinct in the first century AD. However, there are a few references in the literature about the cultivated silphion plant and its existence up to the fifth century. Recently, a rare and endemic Ferula species that produces a pleasant-smelling gum-resin was found in three locations near formerly Greek villages in Anatolia. Morphologic features of this species closely resemble silphion, as it appears in the numismatic figures of antique Cyrenaic coins, and conform to descriptions by ancient authors. Initial chemical and pharmacological investigations of this species have confirmed the medicinal and spice-like quality of its gum-resin supporting a connection with the long-lost silphion. A preliminary conservation study has been initiated at the growth site of this rare endemic Ferula species. The results of this study and their implications on the regional extinction event, and future development of this species will be discussed.

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Section: Discussionmentioning

confidence: 99%

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Miski

2021

Plants

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“…Moreover, it was suggested that FE may be useful in diabetic rats by measuring the levels of oxydative parameters such as SOD, MDA, Catalase and glutathione in both the liver and kidney 11 . Results of our previous studies indicated that that in diabetic and aged rats, FE improves erectile dysfunction due to age, balances testosterone level, antioxidant stress and TNF-α (Tumor-necrosis-factor-α), and also increases the decreased spermatogenesis 10 . For this reason, in the present study, it was not demonstrated the antioxidant and anti-inflammatory activities of FE extract again.…”

Section: Discussionmentioning

confidence: 99%

“…Ferula elaeochytris (FE) is an aphrodisiac effective plant used in the breeding of farm animals grown in Hatay, Kahramanmaraş and the Mediterranean region 7,8 . FE extract has been shown to have anti-inflammatory, antioxidant and antiproliferative 9 effects, beneficial in diabetes-related erectile dysfunction and increase spermatogenesis 10 . In another study, it was reported that it reduced tissue damage in liver, kidney and pancreas in rats with diabetes 11 .…”

Section: Introductionmentioning

confidence: 99%

Ferula elaeochytrisin sıçan kalbinde irisin düzeylerine etkisi

Eser

Türk

Karadağ

et al. 2021

Cukurova Medical Journal

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ÖzPurpose: The aim of this study was to determine the levels of irisin in the heart, which is a vital organ, in rats of different ages and to reveal whether Ferula elaeochytris (FE) has an effect on the expression of the irisin. Materials and Methods: Our study was designed in six groups, young (4 months), middle age (12 months), old (24 months) rats which were given FE extract for 8 weeks and their control groups. After that their heart tissues were taken and irisin levels were measured by immunohistochemical staining method. Results: The obtained results were analyzed by performing histoscoring. It was observed that the level of irisin in old rats was statistically significantly lower in young and middle age rats. In addition, irisin level of in all groups administered with FE extract was found significantly increased. Conclusion: FE extract increases the level of irisin through other pathways besides its protective effect against tissue damage. Amaç: Bu çalışmanın amacı, farklı yaşlardaki sıçanlarda hayati bir organ olan kalpte bulunan irisin düzeylerini belirlemek ve Ferula elaeochytris'in (FE) irisin ekspresyonu üzerine etkisi olup olmadığını ortaya çıkarmaktır.. Gereç ve Yöntem: Çalışmamız 8 hafta boyunca FE ekstraktı verilmiş genç (4 ay), orta yaş (12 ay), yaşlı (24 ay) sıçanlar ve onların kontrol grupları olmak üzere altı grup şeklinde düzenlenmiştir. Ardından kalp dokuları alınarak, kalp dokusunda irisin seviyeleri immünohistokimyasal boyama yöntemi ile ölçülmüştür. Bulgular: Elde edilen sonuçlar histoskorlama yapılarak analiz edilmiştir. Yaşlı sıçanlarda irisin seviyesinin genç ve orta yaş sıçanlara göre istatistiksel olarak anlamlı derecede düşük olduğu gözlenmiştir. Ayrıca FE ekstraktı verilmiş bütün gruplarda irisin düzeylerinde istatistiksel olarak anlamlı derecede anlamlı artış olduğu bulunmuştur. Sonuç: FE ekstraktının doku hasarına karşı koruyucu etkisinin dışında başka yolaklar aracılığıyla da irisin seviyesini artırdığı düşünülmektedir.

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“…A study involving the oral administration of F. elaeochytris extract at concentrations of 40 and 20 mg/kg in aged rats revealed that the extract could positively impact changes in smooth muscle cells and collagen fibrils, tumor necrosis factor-α level, penile neuronal nitric oxide synthase expression, serum testosterone level, neurogenic and endothelial-dependent relaxation of the corpus cavernosum, the ICP/MAP ratio, total antioxidant status, and total oxidant status in corpus cavernosal tissue. The extract also increased serum testosterone levels, decreased tumor necrosis factor-α levels, and balanced oxidative and antioxidant parameters [ 63 ].…”

Section: Ferula Elaeochytrismentioning

confidence: 99%

Review of potential spermatogenic and aphrodisiac effects of the Ferula genus

Bagheri

Shieh

Ghalenoei

et al. 2023

Clin Exp Reprod Med

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Objective: Men’s sexual health plays an important role in male fertility and childbearing, as it is associated with factors such as sexual desire, healthy spermatogenesis, and erectile function. In various cultures, medicinal plants have been utilized to address male sexual issues, including infertility and erectile dysfunction. Despite recent advancements in medical science for treating male impotence, some men opt for herbal supplements as an alternative, given that numerous herbs have the potential to enhance male sexual performance. The Apiaceae family is one of the oldest plant families used for medicinal purposes. Ferula, a genus within this family, comprises approximately 170 different species worldwide. Members of this genus possess numerous therapeutic properties due to the presence of various compounds. This article aims to explore the potential impacts of Ferula plants on the male reproductive system. Methods: This review article was prepared by searching for terms including Ferula and “aphrodisiac,” Ferula and “spermatogenesis,” and Ferula and “male reproductive system.” Relevant information was gathered through electronic databases, including ISI Web of Knowledge, PubMed, and Google Scholar. Results: The findings indicated that relatively comprehensive studies have been conducted in this area, revealing that certain Ferula species have been employed in folk medicine to boost fertility and libido. Recent research has corroborated these effects. Conclusion: It is hoped that new aphrodisiac compounds with fewer side effects can be isolated from Ferula plants in the future.

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The protective effect of Ferula elaeochytris on age-related erectile dysfunction

Cited by 10 publications

References 51 publications

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Next Chapter in the Legend of Silphion: Preliminary Morphological, Chemical, Biological and Pharmacological Evaluations, Initial Conservation Studies, and Reassessment of the Regional Extinction Event

Ferula elaeochytrisin sıçan kalbinde irisin düzeylerine etkisi

Review of potential spermatogenic and aphrodisiac effects of the Ferula genus

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