The protective effect of fenofibrate, triptorelin, and their combination against premature ovarian failure in rats

Abdelzaher, Walaa Yehia; Abdel-Hafez, Sara Mohammed Naguib; Rofaeil, Remon Roshdy; Ali, Abdel Hamid Sayed AboBakr; Hegazy, AbdelRahman; Bahaa, Haitham Ahmed

doi:10.1007/s00210-020-01975-2

Cited by 21 publications

(11 citation statements)

References 44 publications

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“…It was reported that the mean number of primordial, primary, and early antral follicles had no signi cant difference with that of control group (29). Although in some studies, CPA dose of 200 mg/kg followed by 8 mg/kg/day has been introduced for the POF induction in animal models (1,30,31,32), our ndings showed that the least decrease in graaf (18.6%), preantral (15.95%), primary (20.02%) and primordial (21.17%) follicles relative to controls caused by CPA doses of 200 mg/kg. Overall, our results suggest that CPA dose of 50 mg/kg is more suitable for ovarian toxicity induction relative to other concentrations.…”

Section: Discussionmentioning

confidence: 99%

Histological assessment for investigation of dose-dependent ovarian toxicity of cyclophosphamide in the rat

Elahi,

Astaneh,

et al. 2023

Preprint

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Background Cyclophosphamide (CPA) have significant effects on ovarian follicles which lead to ovarian toxicity and impair the normal female reproductive function. This study aimed to evaluate the dose-dependent effects of CPA on rat folliclenumbers. Methods The experimental groups consisted of rats administered a single intraperitoneal injection of CPA at doses of either 50, 75,150, or 200 mg/kg followed by daily doses of 8 mg/kg for 14 days and control group given no treatment. After the treatment period, the histological evaluation was done. Results Primordial and primary follicles were affected by all doses of CPA, but differential follicle counts revealed that graaf and preantral follicles were most sensitive to CPA, followed by primary and primordial follicles. The greatest reduction in all type of studied follicles caused by CPA doses of 50 mg/kg. Conclusion Differential follicle counts revealed that CPA-induced ovarian toxicity is exhibited in structural feature of the ovary, particularly in destruction of graaf and preantral follicles in a dose-dependent manner so that the highest decrease in all type of studied follicles caused by 50 mg/kg of CPA and is suggested as the best concentration for ovotoxicity induction. These findings give insight into ovarian response to structural disruption of folliculogenesis.

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Section: Discussionmentioning

confidence: 99%

Histological assessment for investigation of dose-dependent ovarian toxicity of cyclophosphamide in the rat

Elahi,

Astaneh,

et al. 2023

Preprint

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“…Due to her blood glucose being well-controlled during the injection of dulaglutide, her ovarian hypofunction was not caused by diabetes. Long-term treatment with valsartan/amlodipine xed-dose combination and feno brate has not been reported to cause ovarian hypofunction, but the literature review showed that feno brate protects against premature ovarian failure when used in conjunction with valsartan and amlodipine [5].…”

Section: Discussionmentioning

confidence: 99%

Transient suppression of ovarian function Induced by Dulaglutide: a case report and review of the literature

Guo

Xie

Liu

et al. 2022

Preprint

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BackgroundGlucagon-like peptide-1 (GLP-1) agonist (GLP-1RA) is a new type of hypoglycemic agent with profound effects on the reproductive system. We report a case of ovarian function suppressed by the long-acting GLP-1RA dulaglutide.Case presentationA 41-year-old Chinese female presented with amenorrhea after treatment with GLP-1RA dulaglutide for type 2 diabetes. Her sex hormone measurement showed that the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were increased, while estradiol(E2) level was decreased. Her symptoms improved after the stoppage of dulaglutide. However, LH and FSH levels were still above the normal range two months after discontinuing the injection of dulaglutide.ConclusionThe long-acting GLP-1RA dulaglutide may transiently suppress ovarian function. Because of their different structures and half-times, the individual impact on the reproductive system of each type of GLP-1RA should be monitored in the future.

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“…In addition, the in vitro fertilization rate and embryo development were also affected, whereas the application of CoQ10 successfully reversed these changes [ 30 ]. The use of fenofibrate (FEN), alone or in combination with triptorelin, can improve the expression of PCNA [ 31 ]. The clinical application of FEN promoted the growth of follicles and protected the ovaries from the adverse effects induced by CP.…”

Section: Research On Pcna In Gynecologymentioning

confidence: 99%

Research Progress of PCNA in Reproductive System Diseases

Pan

Zhang

2021

Evidence-Based Complementary and Alternative Medicine

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Reproductive system diseases have become a public health problem that endangers human physical and mental health. The causes of reproductive diseases are complex and diverse. From a biological point of view, abnormal cell proliferation may affect important physiological functions of reproductive organs and cause various gynecological or andrological diseases. Proliferating cell nuclear antigen (PCNA) is the most commonly used indicator for detecting cell proliferation activity. The up- or downregulation of its expression is of great significance in reproductive system diseases. This review summarizes the significance of the latest research on PCNA expression in reproductive system diseases.

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The protective effect of fenofibrate, triptorelin, and their combination against premature ovarian failure in rats

Cited by 21 publications

References 44 publications

Histological assessment for investigation of dose-dependent ovarian toxicity of cyclophosphamide in the rat

Histological assessment for investigation of dose-dependent ovarian toxicity of cyclophosphamide in the rat

Transient suppression of ovarian function Induced by Dulaglutide: a case report and review of the literature

Research Progress of PCNA in Reproductive System Diseases

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