The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment

Fujimori, Honoka; Ohba, Takayoshi; Mikami, Masashi; Nakamura, Shinsuke; Ito, Kenichi; Kojima, Hiroyuki; Takahashi, Tatsuji; Iddamalgoda, Arunasiri; Shimazawa, Masamitsu; Hara, Hideaki

doi:10.1016/j.jphs.2021.11.001

Cited by 8 publications

(2 citation statements)

References 45 publications

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“…The different secondary metabolites generated from C. asiatica were reviewed by Kunjumon et al (41) and have potential to be used in future chemistry, biosynthesis, chemical transformation and biological activity research. There are other novel components of C. asiatica, such as araliadiol, which was recently found to have neuroprotective effects that may prevent cognitive dysfunction (42). Even though this study identified several major metabolites such as "asiaticoside," "asiatic acid," and "madecossoside" as mature keywords.…”

Section: Discussionmentioning

confidence: 88%

Centella asiatica (L.) Urb: A comprehensive bibliometric analysis of published studies between 1857 and 2022

Shafin

Zulkipli²,

Sulaiman³

et al. 2023

Plant Sci. Today

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Centella asiatica (L.) Urban (C. asiatica) is a medicinal plant that generates terpenes, phenols, vitamins, minerals, polyacetylene and fatty acids among other phyto-constituents. This review focuses on the bibliometric analysis of 1164 documents on C. asiatica that were retrieved from the Scopus database. Harzing Publish or Perish and VOSviewer were used for citation and network analyses. According to the bibliometric analysis, publications are on the rise, particularly in the fields of pharmacology, toxicology and pharmaceutics, medicine, biochemistry, genetics and molecular biology, agricultural and biological sciences, and chemistry. "Phytoremediation", "secondary metabolites", "Andrographis paniculata", and "cognitive impairment" are emerging areas for C. asiatica research. However, currently there is a lack of international collaboration in C. asiatica research among contributing countries. Researchers can utilise the findings cited in this reiew to locate potential collaborators, top authors, countries and documents.

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Section: Discussionmentioning

confidence: 88%

Centella asiatica (L.) Urb: A comprehensive bibliometric analysis of published studies between 1857 and 2022

Shafin

Zulkipli²,

Sulaiman³

et al. 2023

Plant Sci. Today

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“…The focus of recent research work to identify such strategies has been shifted to herbal sources, considering the bioactive molecules, safety, and enormous therapeutic potential of herbal medicines (Atanasov et al, 2021). Alternative therapeutic strategies based on herbal remedies such as Hypericum perforatum , Crocus sativus (D'Onofrio et al, 2021), Convolvulus pluricaulis (Kizhakke et al, 2019), Hericium erinaceus (Li et al, 2020), Centella asiatica (Fujimori et al, 2022), Bacopa monnieri (Basheer et al, 2022), Withania somnifera (Das et al, 2021), Uncaria tomentosa (Xu et al, 2021), Curcuma longa (da Costa et al, 2019) etc. have been explored in recent times and have shown some promising results during pre-clinical and clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology and molecular docking approach to unveil the mechanism ofHypericum perforatumin the management of Alzheimer’s disorder

Dogra,

Choudhary,

Parashar

et al. 2023

Preprint

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The pathogenesis of Alzheimer disease (AD) is not fully understood which limits the availability of safer and more efficient therapeutic strategies for the management of AD. There has been growing interest in recent years in exploring the potential of herbal medicines as a source of safer and alternative therapeutic strategies for the management of AD. This study aims to discover the mechanism of Hypericum perforatum in the management of AD using network pharmacology and molecular docking approach. The results of network pharmacology suggest that 39 bioactive molecules of H. perforatum target 127 genes associated with AD, amongst which ATP-dependent translocase, acetylcholinesterase, amyloid-β precursor protein, β-secretase 1, carbonic anhydrase 2, dipeptidyl peptidase 4, epidermal growth factor receptor, tyrosine-protein phosphatase non-receptor type 1, α-synuclein, and vascular endothelial growth factor A seems to be the prominent target of these molecules. Further, the results of molecular docking predicted amentoflavone, I3,II8-biapigenin, rutin, miquelianin, quercetin, luteolin, and nicotiflorin as a promising modulator of target proteins which were determined from network pharmacology to be associated with AD. Our findings suggest that H. perforatum could be a safer and more promising alternative therapeutic strategy for the management of AD by targeting multiple pathways of AD pathogenesis.

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Herbs for Autoimmune Diseases

Mukne,

Dangat,

Shirodkar

et al. 2023

Role of Herbal Medicines

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The protective effect of Centella asiatica and its constituent, araliadiol on neuronal cell damage and cognitive impairment

Cited by 8 publications

References 45 publications

Centella asiatica (L.) Urb: A comprehensive bibliometric analysis of published studies between 1857 and 2022

Centella asiatica (L.) Urb: A comprehensive bibliometric analysis of published studies between 1857 and 2022

Network Pharmacology and molecular docking approach to unveil the mechanism ofHypericum perforatumin the management of Alzheimer’s disorder

Herbs for Autoimmune Diseases

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