The protective effect of CD40 ligand–CD40 signalling is limited during the early phase of <i>Plasmodium</i> infection

Inoue, Shinichi; Niikura, Mamoru; Inoue, Masahito; Mineo, Shoichiro; Kawakami, Yasushi; Uchida, Akihiko; Ohnìshì, H.; Kamiya, Shigeru; Watanabe, Takashi; Kobayashi, Fuminori

doi:10.1016/j.febslet.2014.04.035

Cited by 5 publications

(15 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…41 Plasmodium PAMPs are detected by pattern recognition receptors, such as Toll-like receptors (TLRs), in host immune cells. 5,23 Here, we show that cd T cells modulate humoral immunity against Plasmodium infection. 42 There remains controversy about whether cd T cells elicit or regulate protective immunity against Plasmodium infection.…”

Section: Discussionmentioning

confidence: 80%

“…5,9,19,23 However, the role of cd T cells in humoral immunity against malaria parasites is not well understood. 5,9,19,23 However, the role of cd T cells in humoral immunity against malaria parasites is not well understood.…”

Section: Discussionmentioning

confidence: 99%

“…5,23 This evidence indicates that cd T cells are required for protective immunity against these parasites. 5,23 This evidence indicates that cd T cells are required for protective immunity against these parasites.…”

Section: T Cells Elicit Persistent Humoral Immunity Againstmentioning

confidence: 95%

“…5,9,19,23,26 The parasites were stored as frozen stock in liquid nitrogen or a deep freezer. 5,9,19,23,26 The parasites were stored as frozen stock in liquid nitrogen or a deep freezer.…”

Section: Parasites and Infectionmentioning

confidence: 99%

“…5,21 After inoculation with blood-stage Plasmodium berghei XAT (PbXAT), a low-virulence strain, wild-type (WT) mice show some fluctuations in parasitaemia levels in peripheral blood and eventually controlled the parasite after 1 month. 5,23 A previous study showed that Vc1 + cd T cells modulate the development of the pre-immune peripheral B-cell population but not the immature B-cell population in bone marrow in the naive condition. 9,22 Interferon-c activates phagocytosis by macrophages and monocytes.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

γδ T cells modulate humoral immunity against Plasmodium berghei infection

et al. 2018

Self Cite

View full text Add to dashboard Cite

It is unclear whether γδ T cells are involved in humoral immunity against Plasmodium infection. Here, we show that B-cell-immunodeficient mice and γδ T-cell-deficient mice were incapable of protecting against Plasmodium berghei XAT parasites. γδ T-cell-deficient mice developed reduced levels of antigen-specific antibodies during the late phase of infection. The numbers of follicular helper T cells and germinal centre B cells in γδ T-cell-deficient mice were lower than in wild-type mice during the late phase of infection. Expression profiling of humoral immunity-related cytokines in γδ T cells showed that interleukin-21 (IL-21) and interferon-γ (IFN-γ) are increased during the early stage of infection. Furthermore, blockade of IL-21 and IFN-γ signalling during the early stage of infection led to reduction in follicular helper T cells and germinal centre B cells. γδ T-cell production of IL-21 and IFN-γ is crucial for the development and maintenance of follicular helper T cells and germinal centre B cells during the late phase of infection. Our data suggest that γδ T cells modulate humoral immunity against Plasmodium infection.

show abstract

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: T Cells Elicit Persistent Humoral Immunity Againstmentioning

confidence: 95%

“…5,9,19,23,26 The parasites were stored as frozen stock in liquid nitrogen or a deep freezer. 5,9,19,23,26 The parasites were stored as frozen stock in liquid nitrogen or a deep freezer.…”

Section: Parasites and Infectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

γδ T cells modulate humoral immunity against Plasmodium berghei infection

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

Preferentially expanding Vγ1⁺ γδ T cells are associated with protective immunity against Plasmodium infection in mice

et al. 2017

Self Cite

View full text Add to dashboard Cite

γδ T cells play a crucial role in controlling malaria parasites. Dendritic cell (DC) activation via CD40 ligand (CD40L)-CD40 signaling by γδ T cells induces protective immunity against the blood-stage Plasmodium berghei XAT (PbXAT) parasites in mice. However, it is unknown which γδ T-cell subset has an effector role and is required to control the Plasmodium infection. Here, using antibodies to deplete TCR Vγ1 cells, we saw that Vγ1 γδ T cells were important for the control of PbXAT infection. Splenic Vγ1 γδ T cells preferentially expand and express CD40L, and both Vγ1 and Vγ4 γδ T cells produce IFN-γ during infection. Although expression of CD40L on Vγ1 γδ T cells is maintained during infection, the IFN-γ positivity of Vγ1 γδ T cells is reduced in late-phase infection due to γδ T-cell dysfunction. In Plasmodium-infected IFN-γ signaling-deficient mice, DC activation is reduced, resulting in the suppression of γδ T-cell dysfunction and the dampening of γδ T-cell expansion in the late phase of infection. Our data suggest that Vγ1 γδ T cells represent a major subset responding to PbXAT infection and that the Vγ1 γδ T-cell response is dependent on IFN-γ-activated DCs.

show abstract

Host immunity to Plasmodium infection: Contribution of Plasmodium berghei to our understanding of T cell-related immune response to blood-stage malaria

Ibraheem¹,

Bayarsaikhan²,

Inoue³

2023

Parasitology International

View full text Add to dashboard Cite

The protective effect of CD40 ligand–CD40 signalling is limited during the early phase of Plasmodium infection

Cited by 5 publications

References 35 publications

γδ T cells modulate humoral immunity against Plasmodium berghei infection

γδ T cells modulate humoral immunity against Plasmodium berghei infection

Preferentially expanding Vγ1⁺ γδ T cells are associated with protective immunity against Plasmodium infection in mice

Host immunity to Plasmodium infection: Contribution of Plasmodium berghei to our understanding of T cell-related immune response to blood-stage malaria

Contact Info

Product

Resources

About

The protective effect of CD40 ligand–CD40 signalling is limited during the early phase of Plasmodium infection

Cited by 5 publications

References 35 publications

γδ T cells modulate humoral immunity against Plasmodium berghei infection

γδ T cells modulate humoral immunity against Plasmodium berghei infection

Preferentially expanding Vγ1+ γδ T cells are associated with protective immunity against Plasmodium infection in mice

Host immunity to Plasmodium infection: Contribution of Plasmodium berghei to our understanding of T cell-related immune response to blood-stage malaria

Contact Info

Product

Resources

About

Preferentially expanding Vγ1⁺ γδ T cells are associated with protective immunity against Plasmodium infection in mice