The protective effect of Canova homeopathic medicine in cyclophosphamide-treated non-human primates

Leal, Mariana Ferreira; Antunes, Lusânia Maria Greggi; Lamarão, Maria Fernanda Vita; Silva, Carla Elvira Araújo da; Silva, Ismael Dale Cotrim Guerreiro da; Assumpção, Paulo Pimentel de; Andrade, Edilson; Rezende, Alexandre Pingarilho; Imbeloni, Aline Amaral; Muniz, José Augusto Pereira Carneiro; Pinto, Giovanny R.; Smith, Marı́lia de Arruda Cardoso; Burbano, Rommel Rodrı́guez

doi:10.1016/j.fct.2012.09.002

Cited by 15 publications

(8 citation statements)

References 30 publications

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“…Importantly, the low white blood cell counts in healthy animals is expected, because there is no need to destroy pathogens (Salami, 2018;Duan et al, 2019); similarly, this is important for maintaining high levels of globulins, the animal's humoral defense system. Other studies reported an increase in the number of lymphocytes when the animals received homeopathic medicines (Leal et al 2012;Abud et al 2006;Burbano et al 2009;Cesar et al 2008), unlike what we reported here. We believe that the lower degree of bacterial contamination in the mammary gland was responsible for the reduction of lymphocytes and neutrophils, because these are the first lines of immune defense against pathogens (Cohn and Hirsch, 1960).…”

Section: Discussioncontrasting

confidence: 99%

Addition of a homeopathic, preventive product for mastitis in dairy cow feed: effects on etiologic agents, animal health, production, composition, and quality of milk

Defiltro

Glombowsky

Girardini

et al. 2020

RSD

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The aim of this study was to determine whether the addition of a homeopathic product to dairy cow feed would improve health and production efficiency, as well as composition and quality of milk. The product tested here was produced to stimulate immunity and indirectly to prevent the colonization of the mammary gland by bacteria, thereby decreasing somatic cell counts and bacteria in cow’s milk. Fifty dairy cows were used, divided into two groups: Control (n = 25) and Treated (n = 25). For 90 consecutive days, 50 grams of homeopathic product (treated group) was added to the concentrate; 50 g of the product vehicle (limestone) was added to the concentrate of the control cows. We performed composition and quality analysis on the milk (days 1, 15, 30, 45, 60, 75, and 90) as well as blood collection to carry out hematological and metabolism analyses (days 1, 30, 60, and 90). We found that fat content in the milk cows consuming the homeopathic agent was greater than that of the control group. Because of this increased fat content, there was a tendency towards higher total solids content in treated cows. A treatment effect was found in terms of total bacterial count (TBC); that is, there were lower TBCs in milk of treated animals than in control animals. There was a trend of a treatment effect versus day for somatic cell count (SCC); that is, there were lower SCC in animals that consumed the homeopathic on days 15 and 30 of the experiment. There was no difference between groups in terms of milk production; however, there was a negative correlation between milk production and TBC or SCC in the milk of cows that consumed homeopathic product. Animals in the treated group had lower total leukocyte and lymphocyte counts than did the control group, as well as a tendency toward lower neutrophil counts in these animals. Several bacteria were isolated from the cows' milk during the experimental period, with no treatment effect. In particular, we isolated Corynebacterium spp., Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus hyicus in greater numbers of cows compared to other etiologic agents. Based on these results, we conclude that consumption of the homeopathic product by dairy cows had positive effects on milk quality.

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Section: Discussioncontrasting

confidence: 99%

Addition of a homeopathic, preventive product for mastitis in dairy cow feed: effects on etiologic agents, animal health, production, composition, and quality of milk

Defiltro

Glombowsky

Girardini

et al. 2020

RSD

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“…In spite of its wide range of medical benefits, it can induce many destructive effects on patients under its treatment (Khan et al 2014). Cyclophosphamide (CP) has the ability to induce genetic alterations (Ahmadi et al 2008;Leal et al 2012). It was used in the current study as a positive genotoxic agent.…”

Section: Introductionmentioning

confidence: 99%

Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide

et al. 2020

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Background The genus Albizia (Leguminoseae) is used in folk medicine for the treatment of a wide range of ailments. Recently, saponins from plant origin have attracted much attention. Saponins are recorded to have a broad range of biological and pharmacological activities. This study was performed to evaluate the protective role of Albizia chinensis bark methanolic extract (MEAC) against the genotoxicity induced by cyclophosphamide (CP) using different mutagenic parameters. Results The results showed that MEAC induced an inhibitory effect against chromosomal aberrations of CP in mouse bone marrow and spermatocytes. Such effect was found to be significant (p < 0.01) with a dose of 100 mg/kg treated once for 24 h and also after repeated treatment at a dose of 25 mg/kg for 7 days. In sperm abnormalities, the protective effect of Albizia extract showed a dose-related relationship. Different doses of MEAC (25, 50, and 100 mg/kg) significantly (p < 0.01) ameliorated sperm abnormalities induced by CP dose-dependently. The percentage of sperm abnormalities was decreased to 5.14 ± 0.72 in the group of animals treated with CP plus MEAC (100 mg/kg) indicating an inhibitory effect of about 50%. Conclusion MEAC at the doses examined was non-genotoxic compared to control (negative) and exhibited a protective role against CP genotoxicity.

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“…14,15 Different studies have suggested that homeopathic preparations, such as Canova (Parana, CU, Brazil), can activate macrophages, stimulate the production of ROS and positively affect some cytokines that play an important role in inflammatory processes. [16][17][18][19][20][21] The objective of this research was to evaluate the effect of homeopathic preparations with pathogenic strains of Vibrio, Phosphoricum acidum and Silicea terra on the expression of interleukin-1β (IL-1β), MyD88 and piscidin genes and the antioxidant activities of superoxide dismutase (SOD) and catalase (CAT) of weaning stage (WS-30 days post-hatching [dph]) and early juveniles (EJ-60 dph) of S. rivoliana.…”

Section: Introductionmentioning

confidence: 99%

Immune and Antioxidant Enzyme Response of Longfin Yellowtail (Seriola rivoliana) Juveniles to Ultra-diluted Substances Derived from Phosphorus, Silica and Pathogenic Vibrio

Mazón‐Suástegui¹,

Salas‐Leiva²,

Teles³

et al. 2018

Homeopathy

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Background This research aimed to observe the effect of homeopathic treatments prepared from Vibrio parahaemolyticus and V. alginolyticus (H1) and commercial homeopathic medication Phosphoricum acidum and Silicea terra (H2) on the immune and antioxidant response in Seriola rivoliana juveniles under usual culture conditions and challenged with V. parahaemolyticus. Materials and Methods Quantitative polymerase chain reaction analysis was used to study changes in the expression of key genes related to immune response, cytokines (interleukin-1β [IL-1β]), adapter protein for cytokine release (MyD88) and piscidin and spectrophotometric techniques to analyze the activity of antioxidant superoxide dismutase (SOD) and catalase (CAT) enzymes in Seriola rivoliana juveniles at 30 (weaning stage [WS]) and 60 (early juveniles [EJ]) days post-hatching. Results The H1 treatment led to over-expression of the IL-1β and MyD88 genes in fish at WS and EJ with respect to control, contrary to the H2 treatment that led to under-expression of the IL-1β, MyD88 and piscidin genes at the EJ stage. In fish challenged with V. parahaemolyticus, both H1 and H2 led to over-expression of IL-1β and MyD88; H2 caused an over-expression of piscidin. The SOD activity was higher in H1 with respect to H2 and the control group. CAT remained relatively stable with both H1 and H2 treatments. Conclusions The results suggest that the overall effect of H1 was due to the presence of unknown antigens in low concentrations, while the response to H2—specifically during challenge—may have been due to a stimulating effect of nano-structures, prevailing from mother tincture after sequential dilution/succussion, in a pathway similar to that attributed to nano-vaccines.

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The protective effect of Canova homeopathic medicine in cyclophosphamide-treated non-human primates

Abstract: Our results demonstrated that Canova treatment minimizes cyclophosphamide myelotoxicity in C. apella.

Cited by 15 publications

References 30 publications

Addition of a homeopathic, preventive product for mastitis in dairy cow feed: effects on etiologic agents, animal health, production, composition, and quality of milk

Addition of a homeopathic, preventive product for mastitis in dairy cow feed: effects on etiologic agents, animal health, production, composition, and quality of milk

Albizia chinensis bark extract ameliorates the genotoxic effect of cyclophosphamide

Immune and Antioxidant Enzyme Response of Longfin Yellowtail (Seriola rivoliana) Juveniles to Ultra-diluted Substances Derived from Phosphorus, Silica and Pathogenic Vibrio

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