The protective effect of adipose-derived stem cells against liver injury by trophic molecules

Saito, Yu; Utsunomiya, Tohru; Ikemoto, Tetsuya; Yamada, Shinichiro; Morine, Yuji; Imura, Satoru; Mori, Hiroki; Sugimoto, Kouji; Iwahashi, Shuichi; Asanoma, Michihito

doi:10.1016/j.jss.2012.10.009

Cited by 23 publications

(27 citation statements)

References 37 publications

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“…From these studies, in five, authors performed ADSCs transplantation [14, 17–19, 21], whereas, in two, authors transplanted BM-MSCs [16, 20] (Table 1). In all included papers on MSCs transplantation following PH, authors used rats as experiment animals, except from the study of Saito et al [19], in which authors have performed their experiments in mice. In this part all included studies which respond to the primary endpoints of this systematic review and, consequently, outcomes from MSCs transplantation following PH will be reviewed.…”

Section: Resultsmentioning

confidence: 99%

“…In five studies authors performed ADSCs transplantation following PH [14, 17–19, 21]. Among included literature on MSCs transplantation, specifically reviewed for the aims of this systematic review, effects of MSCs transplantation in the enhancement of LG after PH and improvement of the hepatic function are evaluated and compared.…”

Section: Resultsmentioning

confidence: 99%

“…Saito et al [19] highlight the beneficial role of ADSCs transplantation after 70% PH and ischemia/reperfusion, in mice. Particularly, authors demonstrated that, in vivo, ADSCs had beneficial effects for liver injury after subsequent hepatectomy and ischemia/reperfusion and, in vitro, ADSCs' trophic molecules, including HGF and VEGF, protected hepatocytes.…”

Section: Resultsmentioning

confidence: 99%

“…However, authors found that suppression of VEGF by the administration of bevacizumab did not affect the protective effects of ADSCs. In the same paper, authors demonstrated that a variety of bioactive cytokines secreted by transplanted ADSCs, such as HGF, FGF, and VEGF, might be involved in restoring liver function and promoting regeneration [19]. …”

Section: Resultsmentioning

confidence: 99%

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Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Papanikolaou

Katselis

Αποστόλου

et al. 2017

Stem Cells International

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Mesenchymal stem cells (MSCs) are an attractive source for regenerative medicine because they are easily accessible through minimally invasive methods and have the potential to enhance liver regeneration (LG) and improve liver function, following partial hepatectomy (PH) and acute or chronic liver injury. A systematic review of the literature was conducted for articles published up to September 1st, 2016, using the MEDLINE database. The keywords that were used in various combinations were as follows: “Mesenchymal stem cells”, “transplantation”, “stem cells”, “adipose tissue derived stem cells”, “bone marrow-derived stem cells”, “partial hepatectomy”, “acute liver failure”, “chronic liver failure”, “liver fibrosis”, “liver cirrhosis”, “rats”, “mice”, and “liver regeneration”. All introduced keywords were searched for separately in MeSH Database to control relevance and terminological accuracy and validity. A total of 41 articles were identified for potential inclusion and reviewed in detail. After a strict selection process, a total of 28 articles were excluded, leaving 13 articles to form the basis of this systematic review. MSCs transplantation promoted LG and improved liver function. Furthermore, MSCs had the ability to differentiate in hepatocyte-like cells, increase survival, and protect hepatocytes by paracrine mechanisms. MSCs transplantation may provide beneficial effects in the process of LG after PH and acute or chronic liver injury. They may represent a new therapeutic option to treat posthepatectomy acute liver failure.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Papanikolaou

Katselis

Αποστόλου

et al. 2017

Stem Cells International

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“…74) into conditioned media that predominantly exert anti-apoptotic (Refs 75, 76, 77), immunomodulatory (Refs 78, 79, 80) and angiogenic (Refs 77, 81, 82) effects on co-cultured cell types. Extracellular matrix components and secreted enzymes comprised the largest fraction of the secretome, according to mass spectrometry (Refs 83, 84, 85), but these molecules are unlikely to be heavily involved in the observed paracrine signalling.…”

Section: Comparison Of Trophic Activitymentioning

confidence: 99%

Adipose-derived stromal cells for osteoarticular repair: trophic function versus stem cell activity

Ruetze

Richter

2014

Expert Rev. Mol. Med.

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The identification of multipotent adipose-derived stromal cells (ASC) has raised hope that tissue regeneration approaches established with bone-marrow-derived stromal cells (BMSC) can be reproduced with a cell-type that is far more accessible in large quantities. Recent detailed comparisons, however, revealed subtle functional differences between ASC and BMSC, stressing the concept of a common mesenchymal progenitor existing in a perivascular niche across all tissues. Focussing on bone and cartilage repair, this review summarises recent in vitro and in vivo studies aiming towards tissue regeneration with ASC. Advantages of good accessibility, high yield and superior growth properties are counterbalanced by an inferiority of ASC to form ectopic bone and stimulate long-bone healing along with their less pronounced osteogenic and angiogenic gene expression signature. Hence, particular emphasis is placed on establishing whether stem cell activity of ASC is so far proven and relevant for successful osteochondral regeneration, or whether trophic activity may largely determine therapeutic outcome.

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Changes of liver metabolites following hepatectomy with ischemia reperfusion towards liver regeneration

Saito

Morine

Iwahashi

et al. 2018

Annals of Gastroent Surgery

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BackgroundMetabolome analysis is one of the omics which investigates the final product of a central dogma. Changes of liver metabolites during liver regeneration following hepatectomy (Hx) continue to remain unclear. The aim of the present study was to investigate the changes of liver metabolites following Hx with ischemia reperfusion (I/R) towards liver regeneration.MethodsTwenty‐three patients who underwent Hx were enrolled in this study. Non‐tumor tissues were sampled immediately before and after Hx and a comparison was made between the liver samples taken before and after Hx using capillary electrophoresis (CE)—time‐of‐flight mass spectrometry (TOFMS) as metabolome analysis.ResultsThe metabolic pathway showed that there was a significant increase in “lactate” following Hx. There was a significant decrease in metabolites only in the first half of the tricarboxylic acid cycle (TCA) cycle, and adenosine triphosphate (ATP) by anaerobiotic glycolysis did not occur in time for energy consumption of the Hx. Principal component analysis revealed remarkably different component profiles between the samples taken before and after Hx. One hundred and three metabolites were selected as critical metabolites for separating components. Valine and tryptophan increased significantly after Hx and they were regulated by resected liver volume, ischemic time and liver function.ConclusionThe liver metabolites changed remarkably between before and after Hx. Especially, liver valine and tryptophan were increased.

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The protective effect of adipose-derived stem cells against liver injury by trophic molecules

Cited by 23 publications

References 37 publications

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

Adipose-derived stromal cells for osteoarticular repair: trophic function versus stem cell activity

Changes of liver metabolites following hepatectomy with ischemia reperfusion towards liver regeneration

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