The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats

Yı́lmaz, Erdal; Kertmen, Hayri; Gürer, Bora; Kanat, Mehmet Ali; Arıkök, Ata Türker; Ergüder, Berrin İmge; Hastürk, Aşkın Esen; Ergil, Jülide; Şekerci, Zeki

doi:10.1007/s00701-012-1501-3

Cited by 16 publications

(11 citation statements)

References 38 publications

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“…[ 6 ] However, the planned dose of the application in neurotologic surgery is not that high and former animal studies suggest the neuroprotective feature of systemic MESNA application. [ 2 11 ] A single dose of 150 mg/kg MESNA was shown to decrease the apoptotic activity (caspase-3 activity) in the spinal cord following ischemia/reperfusion injury in a rabbit model. [ 2 ] In another study, MESNA increased the levels of the antioxidant enzymes (glutathione peroxidase and superoxide dismutase), decreased oxidative enzymes and molecules (nitric oxide, nitric oxide synthetase, and xanthine oxidase) and protected the brain tissue histopathologically with systemic administration immediately after the brain injury in rat models.…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 ] In another study, MESNA increased the levels of the antioxidant enzymes (glutathione peroxidase and superoxide dismutase), decreased oxidative enzymes and molecules (nitric oxide, nitric oxide synthetase, and xanthine oxidase) and protected the brain tissue histopathologically with systemic administration immediately after the brain injury in rat models. [ 11 ] These studies showed the neuroprotective effect of MESNA by enzyme systems as a systemic one dose regimen (150 mg/kg) with a short exposure interval (24 h). In guinea pig models, the otologic effects of 10 or 20% of MESNA application locally to the middle ear were analyzed, no toxic effect of MESNA was seen on cochlear morphology or inner ear.…”

Section: Discussionmentioning

confidence: 99%

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The effects of sodium-2-mercaptoethanesulfonate application on the neural and neurovascular tissues: An experimental animal study

et al. 2015

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Background:Sodium-2-mercaptoethanesulfonate (MESNA) is a protective agent that is also used as “a chemical dissector” in various surgical fields. The aim of this study is to evaluate the toxic effects of MESNA on neural and neurovascular structures based on a morphological analysis and examine its safety in neurotological applications.Methods:Three groups of guinea pigs were used as subjects. MESNA solution (50 and 100%) and saline solution were applied to the subarachnoid space over the brain tissue via a middle fossa approach of study and control groups, respectively. Effects of MESNA were assessed by means of light microscope. McNemar Chi-square test was used to evaluate the histopathological findings. Statistical significance of P < 0.05 was taken as criterion.Results:No morphological changes were observed on vascular and neural structures in the study groups in both concentrations, compared to the control group.Conclusions:On a morphological basis, a single application of MESNA does not cause any morphological changes that indicate a toxicity in neural and neurovascular structures.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effects of sodium-2-mercaptoethanesulfonate application on the neural and neurovascular tissues: An experimental animal study

et al. 2015

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“…[13] The expression of proinflammatory cytokines at the site of injury, including IL-1β and TNF-α, regulate precise cellular events that occur within the first few hours of TBI and persist in the neural tissue for several days with cytokines also being detectable on microglia, perivascular macrophages, and astrocytes. [14,15] Most important secondary factors leading to further neuronal death are lipid peroxidation, apoptosis, and development of reactive oxygen species.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic evaluation of interleukin 1-beta antagonist Anakinra against traumatic brain injury in rats

Hastürk

Yı́lmaz

Türkoğlu

et al. 2015

Ulus Travma Acil Cerrahi Derg

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“…Acetaminophen-induced liver injury is associated with significant formation of acrolein, and treatment of mice with MESNA significantly reduces acetaminophen-induced liver injury and acrolein adduct formation [80]. Traumatic brain injury is associated with extremely high levels of RCS and MESNA treatment markedly reduced RCS levels and protected brain tissue in rats subjected to traumatic brain injury [81]. Clinical trials are needed to confirm the efficacy of MESNA against these same conditions in humans.…”

Section: Reactive Carbonyl Species Scavengers Ameliorate Diseasementioning

confidence: 99%

Reactive Carbonyl Species Scavengers—Novel Therapeutic Approaches for Chronic Diseases

Davies

Zhang

2017

Curr Pharmacol Rep

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Purpose of the review To summarize recent evidence supporting the use of reactive carbonyl species scavengers in the prevention and treatment of disease. Recent findings The newly developed 2-aminomethylphenol class of scavengers shows great promise in preclinical trials for a number of diverse conditions including neurodegenerative diseases and cardiovascular disease. In addition, new studies with the thiol-based and imidazole-based scavengers have found new applications outside of adjunctive therapy for chemotherapeutics. Summary Reactive oxygen species (ROS) generated by cells and tissues act as signaling molecules and as cytotoxic agents to defend against pathogens, but ROS also cause collateral damage to vital cellular components. The polyunsaturated fatty acyl chains of phospholipids in the cell membranes are particularly vulnerable to damaging peroxidation by ROS. Evidence suggests that the breakdown of these peroxidized lipids to reactive carbonyls species plays a critical role in many chronic diseases. Antioxidants that abrogate ROS-induced formation of reactive carbonyl species also abrogate normal ROS signaling and thus exert both beneficial and adverse functional effects. The use of scavengers of reactive dicarbonyl species represent an alternative therapeutic strategy to potentially mitigate the adverse effects of ROS without abrogating normal signaling by ROS. In this review, we focus on three classes of reactive carbonyl species scavengers: thiol-based scavengers (2-mercaptoethanesulfonate and amifostine), imidazole-based scavengers (carnosine and its analogs), and 2-aminomethylphenols-based scavengers (pyridoxamine, 2-hydroxybenzylamine, and 5’-O-pentyl-pyridoxamine) that are either undergoing pre-clinical studies, advancing to clinical trials, or are already in clinical use.

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The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats

Abstract: Although further studies considering different dose regimens and time intervals are required, MESNA was shown to be at least as effective as methylprednisolone in the traumatic brain injury model.

Cited by 16 publications

References 38 publications

The effects of sodium-2-mercaptoethanesulfonate application on the neural and neurovascular tissues: An experimental animal study

The effects of sodium-2-mercaptoethanesulfonate application on the neural and neurovascular tissues: An experimental animal study

Therapeutic evaluation of interleukin 1-beta antagonist Anakinra against traumatic brain injury in rats

Reactive Carbonyl Species Scavengers—Novel Therapeutic Approaches for Chronic Diseases

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