The Protective and Treatment Roles of Green Tea Against Hepatotoxicity Induced by Ketoconazol in Male Mice

Atia, Mona; Ragab, Sohair M. M.

doi:10.12816/0043183

Cited by 2 publications

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“…In liver and duodenal tissue injury in humans and rats oxidative activities, pro-inflammatory cytokine responses, increases in plasma AST, and proteinuria were observed, as a result of necrosis and high warfarin intake [ 65 , 66 ]. In another interpretation, it was found that elevation of the AST and ALT levels released into the bloodstream caused liver damage due to the permeability of the hepatocellular membrane under pathological conditions [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

A comprehensive survey of warfarin-induced hepatic toxicity using histopathological, biomarker, and molecular evaluation

Atia,

Mahmoud,

Wilson

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

A comprehensive survey of warfarin-induced hepatic toxicity using histopathological, biomarker, and molecular evaluation

Atia,

Mahmoud,

Wilson

et al. 2024

Heliyon

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Soya milk alleviates toxicity caused by citric acid in male mice: Histopathological and hematological studies

Atia

Mahmoud

2021

J. Food Biochem.

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This study evaluated the toxicity of citric acid and the benefits of soya milk (SM) for preventing damage in mice. Thirty‐five mice were divided into groups: control, mice administered citric acid (CA group) for 30 days, mice administered SM before the administration of citric acid for 30 days (SM + CA group), mice administered citric acid for 15 days and left for recovery (R group), and mice in recovery receiving SM for 15 days (R + SM). Mice in CA and R groups displayed downregulated p53, increased cleavage of caspase 3, and upregulation of Nrf2, CYP1A1, ALT, and AST activity in the liver. In contrast, SM + CA and R + SM treated mice were protected against CA toxicity and showed reversal of p53 downregulation, reduced cleavage of caspase 3, downregulation of Nrf2, and an increase in liver function enzymes. SM administration also restored blood cell and hemoglobin content and general histology of hepatocytes. Practical applications CA causes liver damage, increases inflammation, decreases blood cell numbers, and induces apoptosis. Some natural products, such as SM, have been used to scavenge free radicals that can cause liver damage and hemolysis. This study focuses on the effectiveness of SM in ameliorating CA toxicity and may be helpful in the food industry for managing oxidative stress that may be induced by common dietary constituents. SM may help suppress liver damage and inflammation.

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The Protective and Treatment Roles of Green Tea Against Hepatotoxicity Induced by Ketoconazol in Male Mice

Cited by 2 publications

References 0 publications

A comprehensive survey of warfarin-induced hepatic toxicity using histopathological, biomarker, and molecular evaluation

A comprehensive survey of warfarin-induced hepatic toxicity using histopathological, biomarker, and molecular evaluation

Soya milk alleviates toxicity caused by citric acid in male mice: Histopathological and hematological studies

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