The protective and therapeutic effects of alpha-solanine on mice breast cancer

Mohsenikia, Maryam; Alizadeh, Ali Mohammad; Khodayari, Saeed; Khodayari, Hamid; Kouhpayeh, Shirin; Karimi, Aliasghar; Zamani, Mina; Azizian, Saleh; Mohagheghi, Mohammad Ali

doi:10.1016/j.ejphar.2013.09.015

Cited by 74 publications

(46 citation statements)

References 27 publications

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“…The decrease in Bcl-2 and increase in Bax were also demonstrated in cancer tissue [74]. An increase in proapoptotic Bax protein in breast cancer tissue in mice treated with α-solanine was shown by Mohsenikia et al [75]. However, several other studies have shown that α-solanine can lead to cancer development and metastasis suppression through inhibition of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs) [76].…”

Section: Anticancer Activitymentioning

confidence: 94%

Food Glycoalkaloids: Distribution, Structure, Cytotoxicity, Extraction, and Biological Activity

Siddique¹,

Brunton²

2019

Alkaloids - Their Importance in Nature and Human Life

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Glycoalkaloids (GA), generally occur as plant steroidal glycosides, are secondary metabolites produced in the leaves, flowers, roots, and edible parts including sprouts and skin of the plants of Solanaceae family. Many of the plants in this family have been stable parts of human diets for centuries, and thus, the occurrence of these compounds has been extensively studied mainly due to concerns regarding their toxicity. GAs are produced by plants as a resistance to challenges such as insects and pests but may also produce concentration-dependent toxic effects in humans. Postharvest conditions such as light, temperature, humidity, and processing conditions may also affect GA content in edible plants producing them. Since these compounds also possess biological properties such as anti-inflammatory, antimicrobial, and anticarcinogenic activities, it could be a useful strategy to use novel extraction techniques to maintaining bioactivities after extraction and simultaneously to reduce toxicity in the source plants. This chapter aims to describe alkaloids especially GAs commonly occurring in foods, their structure and toxicity, and postharvesting practices which influence alkaloid content and utilization of conventional and novel technologies to extract food alkaloids.

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Section: Anticancer Activitymentioning

confidence: 94%

Food Glycoalkaloids: Distribution, Structure, Cytotoxicity, Extraction, and Biological Activity

Siddique¹,

Brunton²

2019

Alkaloids - Their Importance in Nature and Human Life

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show abstract

“…The concentration of solanine is 5 µg/µl. Solanine had a remarkable safety at the dose of 5 µg/g(weight of mice), and there were no clinical and histological differences between the treatment and the control groups [25]. Each group was treated with drug 1 time per day for two weeks.…”

Section: Methodsmentioning

confidence: 99%

Antitumor Efficacy of α-Solanine against Pancreatic Cancer In Vitro and In Vivo

Kong

Dong

et al. 2014

PLoS ONE

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α-solanine, a steroidal glycoalkaloid in potato, was found to have proliferation-inhibiting and apoptosis-promoting effect on multiple cancer cells, such as clone, liver, melanoma cancer cells. However, the antitumor efficacy of α-solanine on pancreatic cancer has not been fully evaluated. In this study, we inquired into the anti-carcinogenic effect of α-solanine against human pancreatic cancer cells. In the present study, we investigated the anti-carcinogenic effect of α-solanine against human pancreatic cancer cells. In vitro, α-solanine inhibited proliferation of PANC-1, sw1990, MIA PaCa-2 cells in a dose-dependent manner, as well as cell migration and invasion with atoxic doses. The expression of MMP-2/9, extracellular inducer of matrix metalloproteinase (EMMPRIN), CD44, eNOS and E-cadherin were suppressed by α-solanine in PANC-1 cells. Moreover, significantly decreased vascular endothelial growth factor (VEGF) expression and tube formation of endothelial cells were discerned following α-solanine treatment. Suppressed phosphorylation of Akt, mTOR, and Stat3, and strengthen phosphorylation of β-catenin was found, along with markedly decreased tran-nuclear of NF-κB, β-catenin and TCF-1. Following the administration of α-solanine (6 µg/g for 2 weeks) in xenograft model, tumor volume and weight were decreased by 61% and 43% (p<0.05) respectively, showing decreased MMP-2/9, PCNA and VEGF expression. In conclusion, α-solanine showed beneficial effects on pancreatic cancer in vitro and in vivo, which may via suppressing the pathway proliferation, angiogenesis and metastasis.

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“…shown that α-solanine demonstrates anti-metastatic activity in different types of cancers (16)(17)(18)(19) and chemoprotective and chemotherapeutic effects in animal models of breast cancer (20). In our previous study, we found that α-solanine modulated the radiosensitivity of esophageal cancer cells by inducing miR-138 expression (21).…”

Section: Introductionmentioning

confidence: 92%

α-solanine enhances the chemosensitivity of esophageal cancer cells by inducing microRNA‑138 expression

Wang

et al. 2018

Oncol Rep

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Esophageal cancer is a common malignant tumor worldwide. Inherent and acquired drug resistance are the major challenges faced in anticancer chemotherapy. This study aimed to explore the effects of α-solanine in regards to the chemosensitivity of esophageal cancer cells. We found that α-solanine enhanced the sensitivity of EC9706 and KYSE30 cells to 5-flurouracil (5-FU) and cisplatin (Cis) by promoting drug-induced apoptosis. qRT-PCR and western blotting results showed that α-solanine treatment promoted miR-138 expression and decreased survivin expression in EC9706 and KYSE30 cells. α-solanine also enhanced the inhibitory effects of 5-Fu and Cis in EC9706 transplanted tumors in mouse models. Dual-Luciferase reporter assay results confirmed survivin as the direct target gene of miR-138. MiR-138 inhibited survivin expression in EC9706 and KYSE30 cells. And miR-138 mimic and si-survivin had similar effects with α-solanine in suppressing survivin expression and promoting cancer cell death. miR-138 inhibitor reversed the chemosensitivity-enhancing effect of α-solanine. In EC9706 and KYSE30 cells, survivin overexpression rescued the cancer cells from apoptosis caused by α-solanine and miR-138 mimic expression. From these findings, we conclude that α-solanine enhanced the chemosensitivity of esophageal cancer cells to chemotherapy via the miR-138/survivin pathway. This study provides insight into the molecular mechanism underlying the chemosensitivity-enhancing function of α-solanine and suggests a new chemotherapeutic strategy for esophageal cancer treatment.

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The protective and therapeutic effects of alpha-solanine on mice breast cancer

Cited by 74 publications

References 27 publications

Food Glycoalkaloids: Distribution, Structure, Cytotoxicity, Extraction, and Biological Activity

Food Glycoalkaloids: Distribution, Structure, Cytotoxicity, Extraction, and Biological Activity

Antitumor Efficacy of α-Solanine against Pancreatic Cancer In Vitro and In Vivo

α-solanine enhances the chemosensitivity of esophageal cancer cells by inducing microRNA‑138 expression

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