The protection of selenium on cadmium-induced inhibition of spermatogenesis via activating testosterone synthesis in mice

Ren, Xiangmei; Wang, Gaigai; Xu, Dongqing; Luo, K.X.; Liu, Yuxin; Zhong, Yun‐Shi; Cai, Yuanqing

doi:10.1016/j.fct.2012.07.021

Cited by 61 publications

(33 citation statements)

References 50 publications

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“…A recent in vivo study found that exposure to a reproductive toxicant, cadmium (Cd), not only resulted in a significant decrease in sperm concentrations and motility but also serum testosterone levels and superoxide dismutase and glutathione peroxidase activities, in addition to an increase in serum malondialdehyde concentrations. Reportedly, pretreatment with selenium (Se), a potent antioxidant, alleviated the oxidative stress-related phenomena (Ren et al 2012). These results suggest that the reduction in oxidative stress may improve steroidogenesis activity, which may explain the higher testosterone levels with VA-SDR treatment than with VA-Hay, as observed in our study.…”

Section: Discussionsupporting

confidence: 77%

“…Reportedly, pretreatment with selenium (Se), a potent antioxidant, alleviated the oxidative stress‐related phenomena (Ren et al . ). These results suggest that the reduction in oxidative stress may improve steroidogenesis activity, which may explain the higher testosterone levels with VA‐SDR treatment than with VA‐Hay, as observed in our study.…”

Section: Discussionmentioning

confidence: 97%

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Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers

Tseng

Chen

Lai

et al. 2015

Animal Science Journal

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For this study, we aimed to assess the dose-response antiosteoporotic effects of the middle section of velvet antlers (VAs) from sika deers (Cervus nippon) fed with different types of fodders. VAs prepared from farmed sika deers fed with feed mixtures containing sorghum distillery residue (VA-SDR) or without SDR (SDR replaced with hay, VA-Hay) were divided into upper (VAU), middle (VAM) and basal (VAB) sections. The chemical constituents of the middle sections obtained from each VA type were compared, and their antiosteoporotic activities were evaluated using rats with ovaries removed surgically (ovariectomy, OVX). The VA-Hay exhibited markedly increased iron and cysteine levels, whereas the VA-SDR exhibited markedly increased level of alcoholic extract and testosterone. Both VA-Hay- and VA-SDR-treated rats exhibited increased femur strength compared with the control group. However, VA-SDR exhibited greater bone-strengthening effects than did VA-Hay. The serum osteocalcin and estradiol levels were significantly moderated in the VA-Hay group alone. These results suggest that VA-SDR and VA-Hay prevent the loss of bone strength, and preserve trabecular architecture connectivity in an estrogen-deficient state. However, differences in the chemical compositions of different forages may be responsible for the varying antiosteoporotic mechanisms observed. Thus, the addition of SDR in deer forage may enhance antiosteoporosis activity in VAs, and confer considerable economic and ecological benefits.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 97%

Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers

Tseng

Chen

Lai

et al. 2015

Animal Science Journal

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“…Excessive Ni and its compounds are ubiquitous environmental pollutants and can cause testicular damage and interfere with male reproductive system . Se is commonly recognized as a protective element exerting antagonistic effects toward toxicity elicited by cadmium (Cd), mercury (Hg), copper (Cu), and other metals . Work by El‐Boshy et al suggested that Se could relieve Cd‐induced oxidative damage in the rat liver and kidney.…”

Section: Discussionmentioning

confidence: 99%

Nano‐selenium attenuates nickel‐induced testosterone synthesis disturbance through inhibition of MAPK pathways in Sprague‐Dawley rats

Gan

Zhang

Qiannan

et al. 2019

Environmental Toxicology

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The aim of this study was to investigate the protective effects of Nano-Se against Ni-induced testosterone synthesis disorder in rats and determine the underlying protective mechanism. Sprague-Dawley rats were co-treated with Ni (5.0 mg/kg, i.p.) and Nano-Se (0.5, 1.0, and 2.0 mg/kg, oral gavage) for 14 days after which various endpoints were evaluated. The Ni-induced abnormal pathological changes and elevated 8-OHdG levels in the testes were attenuated by Nano-Se administration.Importantly, decreased serum testosterone levels in the Ni-treated rats were significantly restored by Nano-Se treatment, particularly at 1.0 and 2.0 mg/kg. Furthermore, the mRNA and protein levels of testosterone synthetase were increased by Nano-Se compared to the Ni group, whereas phosphorylated protein expression levels of mitogen-activated protein kinase (MAPK) pathways were suppressed by Nano-Se administration in the Ni-treated rats. Overall, the results suggest that Nano-Se may ameliorate the Ni-induced testosterone synthesis disturbance via the inhibition of ERK1/2, p38, and JNK MAPK pathways.

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“…Previous studies have reported that some phytochemicals including gallic acid has the potential to protect against oxidative stress in the testes and to reversed sperm abnormalities [25, 34]. Another study showed that selenium had beneficial effects on male infertility, wherein it improved the sperm count and motility, increased serum testosterone levels and alleviated the histopathological changes in the testes [3, 32, 33]. Furthermore, our results are in agreement with those of previous studies, showing that VC treatment in diabetic rats increased sperm concentration and motility, increased serum testosterone levels and improve the testicular microstructure.…”

Section: Discussionmentioning

confidence: 99%

Effects of <i>Vernonia cinerea</i> on reproductive performance in streptozotocin-induced diabetic rats

Pomjunya

Ratthanophart²,

Fungfuang

2017

The Journal of Veterinary Medical Science

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The present study investigated the effects of Vernonia cinerea (VC) on the reproductive function in streptozotocin (STZ)-induced diabetic male rats. Six-week-old male Sprague-Dawley rats were randomly divided into four groups: group 1, normal control rats; group 2, diabetic untreated rats; group 3, diabetic rats treated with VC (10 mg/kg); and group 4, diabetic rats treated with VC (40 mg/kg). Diabetes mellitus (DM) was induced by intraperitoneal injection of STZ (60 mg/kg). All animals were treated for 30 consecutive days. Body weight, blood glucose, food intake, epididymal sperm parameters, testicular microstructure and serum testosterone levels were evaluated. VC treatment significantly restored the sperm motility and testosterone concentration, and decreased the testicular histopathological changes in DM rats. Moreover, high-dose VC exhibited an antidibetic activity and significantly improved the sperm count. In conclusion, we found, for the first time, that administration of VC significantly restored the testicular function and testosterone concentration in diabetic male rats.

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The protection of selenium on cadmium-induced inhibition of spermatogenesis via activating testosterone synthesis in mice

Cited by 61 publications

References 50 publications

Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers

Effects of different forages on the chemical compositions and antiosteoporotic activities of velvet antlers

Nano‐selenium attenuates nickel‐induced testosterone synthesis disturbance through inhibition of MAPK pathways in Sprague‐Dawley rats

Effects of <i>Vernonia cinerea</i> on reproductive performance in streptozotocin-induced diabetic rats

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