The Proteasome Inhibitor Bortezomib Inhibits Inflammatory Response of Periodontal Ligament Cells and Ameliorates Experimental Periodontitis in Rats

Jiang, Lin; Song, Jinlin; Hu, Xiaolei; Zhang, Hongmei; Huang, Enyi; Zhang, Yan; Deng, Feng; Wu, Xiaomian

doi:10.1902/jop.2016.160396

Cited by 15 publications

(15 citation statements)

References 34 publications

(39 reference statements)

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“…Other relevant factors are porosity, fiber size, individual fiber orientation in the mesh, entanglements of the fiber, and so on. It has been reported that HA nano-particle incorporation within the PHB fibers significantly improved the mechanical properties of PHB mats with an increase of 67% of the elastic modulus and 51% of the tensile strength at break [20]. In this study, we found chitosan nano-particles adhesive bonding to the junction of the PLA fibers.…”

Section: Discussionsupporting

confidence: 63%

“…The tensile deformation of nanofibers is strongly dependent on the level of the nano-fibers alignment within the mat, interface adhesion of fiber-fiber contact and fiber lay-ups [18,19]. Usually, the modulus and tensile strength of the mats with uniaxially oriented fibers are higher than that of the non-woven fiber mat [20]. Other relevant factors are porosity, fiber size, individual fiber orientation in the mesh, entanglements of the fiber, and so on.…”

Section: Discussionmentioning

confidence: 99%

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The use of chitosan/PLA nano-fibers by emulsion eletrospinning for periodontal tissue engineering

Shen

Xue

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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The combination of chitosan nano-particles enhanced the mechanical properties of pure PLA nano-fibers and increased its hydrophilicity. Pure PLA nano-fibers scaffold facilitated BMSCs proliferation. Adding an appropriate amount of chitosan nano-particles may promote its properties of cell proliferation and osteogenic differentiation. The higher expression of inflammatory mediators caused by nano-fibers may be regulated via TLR4 pathway.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

The use of chitosan/PLA nano-fibers by emulsion eletrospinning for periodontal tissue engineering

Shen

Xue

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…It has been reported that bortezomib inhibits the expression of IL-1β and prevents alveolar bone absorption in experimental periodontitis. 166 CONCLUSION IL-1β is an important pro-inflammatory cytokine and participates in periodontitis. As a strong stimulator of bone resorption, continuous bone loss may be induced by IL-1β.…”

Section: Other Potential Agents That Influence Il-1β In Periodontitismentioning

confidence: 99%

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

et al. 2020

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Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis.

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“…Bone remodeling requires a precise balance between bone formation and resorption (Sato et al, 2016). It is well-known that RANKL is a cytokine which can induce the differentiation of progenitor cells into mature osteoclast (Jiang et al, 2016). Conversely, OPG is an osteoprotegerin which can block the binding of a RANK ligand (RANKL) to the RANK receptor (Kurinami et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects and Toxicity Studies of Xian-ling-gu-bao on Bone Metabolism in Ovariectomized Rats

Zhong

Wang

et al. 2017

Front. Pharmacol.

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Xian-ling-gu-bao (XLGB) is a well-known patented traditional Chinese prescription widely used to treat osteoporosis, osteoarthritis, aseptic bone necrosis, or climacteric syndrome. However, recent reports have suggested that XLGB may cause liver injury in humans. In the present study, we aimed to evaluate the efficacy of XLGB in the prevention of osteoporosis in the zebrafish and ovariectomized (OVX) rats, both of which have been used as osteoporosis models. The safety of XLGB after long-term administration to OVX rats was also assessed. OVX rats were administered by oral gavage 270 mg/kg (recommended daily dose), 1350 mg/kg, and 1800 mg/kg of XLGB for 26 weeks. Bone mineral density, relative bone surface to bone volume, relative bone volume to total volume, trabecular number, mean trabecular thickness, and mean trabecular spacing in OVX rats were examined at the end of the 26-week dosing period. Additionally, OPG and RANKL expression in the femur were determined by western blot and immunohistochemical staining. To evaluate the safety of XLGB, body weight, hematology, serum biochemistry markers related to toxicology, and organ histopathology were determined in each group of OVX rats. Conversely, the zebrafish was treated with prednisolone to induce osteoporosis in the embryo. Disodium etidronate was used as a treatment control. XLGB was shown to be effective in preventing osteoporosis in both the OVX rats and the prednisolone-treated zebrafish. Similarly, XLGB increased OPG protein and decreased RANKL protein in OVX rats. Interestingly, no obvious toxicity was observed in the heart, liver, kidney, small intestine, or stomach at dosages of up to 1800 mg/kg after treating the OVX rats for 26 weeks. XLGB was shown to be very effective in treating osteoporosis in OVX rats. No obvious toxicity or adverse effects developed in OVX rats at dosages up to 1800 mg/kg, which is equivalent to six times the daily-recommended dose. Therefore, XLGB should be considered a good option for the treatment of post-menopausal osteoporosis.

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The Proteasome Inhibitor Bortezomib Inhibits Inflammatory Response of Periodontal Ligament Cells and Ameliorates Experimental Periodontitis in Rats

Abstract: These findings demonstrate the anti-inflammatory activity of BTZ against periodontal inflammatory response and present BTZ as a promising therapy for periodontal disease.

Cited by 15 publications

References 34 publications

The use of chitosan/PLA nano-fibers by emulsion eletrospinning for periodontal tissue engineering

The use of chitosan/PLA nano-fibers by emulsion eletrospinning for periodontal tissue engineering

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

Beneficial Effects and Toxicity Studies of Xian-ling-gu-bao on Bone Metabolism in Ovariectomized Rats

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