The Proteasome Inhibitor Bortezomib Induces p53-Dependent Apoptosis in Activated B Cells
Trini A. Ochoa,
Amy Rossi,
E. Steve Woodle
et al.
Abstract:The proteasome inhibitor bortezomib (BTZ) is proposed to deplete activated B cells and plasma cells. However, a complete picture of the mechanisms underlying BTZ-induced apoptosis in B lineage cells remains to be established. In this study, using a direct in vitro approach, we show that deletion of the tumor suppressor and cell cycle regulator p53 rescues recently activated mouse B cells from BTZ-induced apoptosis. Furthermore, BTZ treatment elevated intracellular p53 levels, and p53 deletion constrained apopt… Show more
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