The Prostate Gland

Sharma, Mona; Gupta, Surabhi; Dhole, Bodhana; Kumar, Anand

doi:10.1007/978-981-10-3695-8_2

Cited by 4 publications

(6 citation statements)

References 49 publications

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“…5 Mature prostatic epithelium is composed of luminal cells, basal cells, neuroendocrine cells, and transit-amplifying (TA) cells. 3 Luminal cells are the most differentiated members of prostatic epithelium. They constitute the lining of glandular acini and secrete prostate specific antigen (PSA) and prostatic acid phosphatase (PAP).…”

Section: Origin Of Cell Lineagesmentioning

confidence: 99%

“…They lack secretory vesicles in their cytoplasm. 3 TA cells that localize in both luminal and basal layers express both the basal and luminal cell surface markers. 7 Highly specialized neuroendocrine cells possess less than 1% share of the total epithelial cell population and are characterized by the expression of neurotransmitters like serotonin, bombesin etc.…”

Section: Origin Of Cell Lineagesmentioning

confidence: 99%

“…16 Based on various experimental evidences, different models have been devised to explain the routes of differentiation of multipotent prostate stem cells into other epithelial cell types: a) Linear differentiation model, b) Bidirectional differentiation model, and c) Independent lineage model. 3,17,18 All these hypothetical models are schematically explained in Figure 1.…”

Section: Origin Of Cell Lineagesmentioning

confidence: 99%

“…Notwithstanding being few in number, they reserve the 'keystone' position among the prostatic epithelial cells owing to their potential for self-renewal and differentiation. 2,3 With the growing popularity of the hierarchical model of solid tumorigenesis, prostate cancer stem cells are being suspected as a derivative of the resident stem cells because of a considerable overlap of the surface markers. 4…”

Section: Introductionmentioning

confidence: 99%

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Stem cell repertoire in the prostate epithelium

Choudhury

Kumar

Kharb

et al. 2019

JSRT

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Over the past two decades, the roles of stem cells have been studied in the contexts of developmental biology, tissue engineering, cancer therapy, neurodegenerative disorders and what not! Right since the discovery of prostate specific adult stem cells or stem-like cells in both stromal and epithelial compartments, their participation in prostate development and prostatic pathologies (like benign prostatic hyperplasia and prostate cancer) are being thoroughly investigated. The present mini-review summarizes the ins and outs of the histological organization of acinar prostate and prostate cancer, keeping the prostate-specific epithelial stem cells on the backdrop.

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Section: Origin Of Cell Lineagesmentioning

confidence: 99%

Section: Origin Of Cell Lineagesmentioning

confidence: 99%

Section: Origin Of Cell Lineagesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Stem cell repertoire in the prostate epithelium

Choudhury

Kumar

Kharb

et al. 2019

JSRT

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“…The prostate, an accessory gland of the reproductive system located in the inferior part of the urinary bladder around the prostatic urethral part in males is composed of both exocrine and endocrine parts [1,2]. The exocrine part of the prostate can undergo a non-cancerous proliferation characterized by pathological cellular multiplication of epithelial and smooth muscle cells a condition referred to as Benign Prostatic Hyperplasia [3].…”

Section: Introductionmentioning

confidence: 99%

Histostereological Restorative and Inhibitory Effects of Crude Methanolic Bark Extract of Prunus Africanus on Testosterone-Induced Benign Prostatic Hyperplasia in Wistar Rats

Mwangi

Kariuki

Warimu

et al. 2021

EJMP

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Aim: To evaluate the histostereological effects of P. africanus on testosterone induced Benign Prostatic Hyperplasia (BPH) in Wistar rats. Place and Duration of Study: The study was carried out for six weeks in Jomo Kenyatta University of Agriculture and Technology. Methodology: A sample size of sixty Wistar were used as the experimental model and they were divided into two study groups of 30 rats in the restorative group and 30 rats in the inhibitory group. Each group was further categorized into 5 control and 25 experimental rats. The experimental rats were further subdivided into 5 sub-groups based on varying doses of the crude methanolic bark extract of P. africanus (0 mg, 25 mg, 50 mg, 125 mg, and 200 mg). BPH in experimental animal was induced by subcutaneous injection of testosterone propionate (7.5 mg/kg) for 10 days. Results: The findings of the study showed that the restorative group had a statistical significant (P<0.05) ((dose dependent reduction of the prostate volume, the stromal and epithelium volume was observed. While in the inhibitory group a statistical significant (P<0.05) dose-related inhibition, in the increase of the prostate volume, the stromal and epithelium volume was observed. In conclusion, the maximal restorative effect was observed to be up to 85.6% and at a dose of 200 mg, while the optimal inhibitory effects were observed to be between 66.7- 68.4% in the dose range of 100-200 mg/kg/body weight. Conclusion: Crude methanolic bark extract of P. africanus has both restorative.

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