The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasive
Streptococcus pneumoniae
Manmeet Bhalla,
Sydney Herring,
Alexsandra Lenhard
et al.
Abstract:Streptococcus pneumoniae
(pneumococcus) remains a serious cause of pulmonary and systemic infections globally, and host-directed therapies are lacking. The aim of this study was to test the therapeutic efficacy of asapiprant, an inhibitor of prostaglandin D2 signaling, against pneumococcal infection. Treatment of young mice with asapiprant after pulmonary infection with invasive pneumococci significantly reduced systemic spread, disease severity, and host death. Protection was specific against ba… Show more
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