The Prospects for the Therapeutic Implications of Genetically Engineered Probiotics

Abstract

The interest in the therapeutic use of probiotic microorganisms has been increased during the last decade although the doubts have ascended about the probiotics mainly because their beneficial effects are not fully understood, and, in many cases, their usefulness has not been validated in clinical trials. Consequently, the notion got a considerable interest in those strains having proven probiotic potential to be engineered for improvement in their beneficial features. The process of genetic engineering can also be used for probiotic strains for the reversion of antimicrobial resistance and other modifications for their safer and effective human applications. The lactic acid bacilli are predominantly opposite as they already have gained attention owing to their health-promoting benefits and their safety for human consumption; therefore, their use, especially as a delivery agent of vaccines and drugs, is gaining attention. The tailoring of probiotic strains will not only improve the data regarding the probiotic potential of these strains but also clinch the doubts concerning these probiotics. This article focuses on the approaches of bioengineered probiotics and discusses the potential prospects for their therapeutic applications including immunomodulation, cognitive health, and anticancer therapeutics.

Study of exopolysaccharides from lactic acid bacteria and their industrial applications: a review

“…Nevertheless, cheese made with starters producing EPSs has higher moisture levels and a microstructure similar to full‐fat cheeses, because binding and water retention are increased (Lynch et al ., 2018b). Moreover, the excellent water‐binding capacity of EPSs could contribute to increase the shelf life of cheeses (Mazhar et al ., 2020).…”

Critical Overview of Probiotics Efficacy on Health and its Safety

“…(3) probiotics maintain the gut mucosal barriers, i.e., the chemical barriers such as antimicrobial peptides (AMPs), which can inhibit the invading microorganisms, and the physical barriers including cellular junction and the mucus layer that repel the invading microorganisms. (4) alliance of microbiota with the immune system allows the maintenance of regulatory function involved in the conservation of tolerance to safer antigens and induction of protection to the pathogens 35 .…”

“…Review product-specific instructions for administration and storage, and avoid products that are near or past their expiration date 114 . For chronic conditions, counsel consumers that continued use of a probiotic are usually advised because probiotics do not cause long-lasting changes in the gut microbiota 35,115 .…”

Biotechnological Innovations and Therapeutic Application of Pediococcus and Lactic Acid Bacteria: The Next-Generation Microorganism

“…Recently, with the growing understanding of the human microbiome, to prevent and cure some health conditions, probiotics have received considerable attention in bioengineering to support human health. Helped by the extended creation of tools and methods, probiotics are engineered as live biotherapeutics for studying and prevention of many diseases ( Mazhar et al, 2020 ). By stabilizing the gastrointestinal tract, it might offer health-promoting benefits.…”