The prospects for early detection with optical coherence tomography (OCT) and OCT angiography in major depressive disorder

Xiao, Qian; Li, Fangling; Jiang, Furong; Zhang, Zhejia; Xu, Bei

doi:10.1016/j.jad.2023.11.031

Cited by 1 publication

(2 citation statements)

References 38 publications

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“… 7 Interestingly, OCTA has been used for researching psychiatric disorders (schizophrenia, bipolar disorder, and major depressive disorder) in recent years. 8 , 9 , 10 All three psychiatric disorders show retinal changes detectable through OCT and OCTA. This suggests a potential common pathway in these psychiatric disorders where retinal microvascular changes are involved.…”

Section: Introductionmentioning

confidence: 99%

“…In patients with major depressive disorder, OCTA has shown reduced retinal vessel density and thinning of the subfoveal choroid. 9 , 10 Patients with schizophrenia and bipolar disorder have demonstrated microvascular dysfunction in the retina, especially in its central part. 8 Although, there is a lack of OCTA or OCT research on BPD, and the relationship between BPD and retinal microvascular density and morphology is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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The use of optical coherence tomography (OCT) and OCT angiography in borderline personality disorder compared to health control subjects

Xu,

Li,

Zhang

et al. 2024

CNS Neurosci Ther

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BackgroundOptical coherence tomography (OCT) or OCT angiography (OCTA) has been investigated in few research studies of psychiatric disorders. No research has been done using OCT or OCTA in patients with borderline personality disorder (BPD).MethodsOCTA measured foveal avascular zone (FAZ), macular vessel density (MVD), and peripapillary vessel density (PVD). OCT measured the peripapillary retinal fiber layer (RNFL) and central retinal thickness (CRT). The study utilized the Ottawa Self‐Injury Inventory, Hamilton Anxiety Rating Scale (HAMA), and Global Assessment of Functioning (GAF) to assess the symptom characteristics of individuals with BPD.ResultsFifty‐nine eyes of BPD patients and 58 eyes of normal subjects were analyzed, MVD of the superficial retinal capillary plexus declined noticeably in most subfields (p < 0.05). Significant differences were observed in the whole inner ring and outer ring index between BPD and HC groups (p < 0.05). The patients with BPD exhibited lower RNFL and CRT, the difference was significant (p < 0.05). CRT indicated a significant negative correlation with the Ottawa Self‐Injury Inventory (p < 0.05). In addition, we observed that there was a negative correlation identified between the MVD of the inner ring and HAMA (p < 0.05). Meanwhile, the MVD of the outer ring was positively correlated with GAF (p < 0.05). The areas under the receiver operating characteristic curves (AUROCs) for distinguishing BPD and HC eyes in OCTA were the highest for fovea MVD (0.679), followed by outer ring MVD (0.669), inner ring MVD (0.641), FAZ (0.579). In OCT, CRT was highest for BPD (0.711), followed by RNFL (0.625).ConclusionThe OCT and OCTA can non‐invasively detect microvascular and morphology changes of the retina in BPD patients compared to healthy control subjects.

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