The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study

Holcomb, John B.; Junco, Deborah J. del; Fox, Erin E.; Wade, Charles E.; Cohen, Mitchell J.; Schreiber, Martin A.; Alarcon, Louis H.; Bai, Yu; Brasel, Karen J.; Bulger, Eileen M.; Cotton, Bryan A.; Matijevic, Nena; Muskat, Peter; Myers, John G.; Phelan, Herb A.; White, Christopher E.; Zhang, Jiajie; Rahbar, Mohammad Hossein

doi:10.1001/2013.jamasurg.387

Cited by 874 publications

(398 citation statements)

References 67 publications

(64 reference statements)

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“…The adoption of the management principles espoused by the WSACS -the Abdominal Compartment Society appear to be highly correlated with significant improved survival and cost efficiency [10]. The coincident evolution in resuscitation with hemostatic or balanced blood component resuscitation strategies [11][12][13][14] that limit use of crystalloid fluids are most probably also highly associated with a reduction in the prevalence of ACS (recognizing that excess crystalloid fluids are likely to be central in many cases of IAH/ACS) [15,16]. In support of these practices, a reduced incidence of open abdomens and ACS [17], and higher rates of abdominal closure with the adoption of damage control resuscitation and the use of negative pressure peritoneal therapy have been noted [18][19][20].…”

Section: The Pastmentioning

confidence: 99%

Update from the Abdominal Compartment Society (WSACS) on intra-abdominal hypertension and abdominal compartment syndrome: past, present, and future beyond Banff 2017

Kirkpatrick¹,

Sugrue²,

McKee³

et al. 2017

Anaesthesiol Intensive Ther

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Section: The Pastmentioning

confidence: 99%

Update from the Abdominal Compartment Society (WSACS) on intra-abdominal hypertension and abdominal compartment syndrome: past, present, and future beyond Banff 2017

Kirkpatrick¹,

Sugrue²,

McKee³

et al. 2017

Anaesthesiol Intensive Ther

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“…However, there are no reports suggesting positive effects of cryoprecipitate administration on the survival of exsanguinating trauma patients [58][59][60]. Although cryoprecipitate contains high concentrations of fibrinogen, it is hampered by several relevant disadvantages in terms of its availability, allogenicity, and the need for blood type matching and time-consuming thawing.…”

Section: Cryoprecipitatementioning

confidence: 99%

“…Although cryoprecipitate contains high concentrations of fibrinogen, it is hampered by several relevant disadvantages in terms of its availability, allogenicity, and the need for blood type matching and time-consuming thawing. Because the timing and indications for the administration of cryoprecipitate were unclear in the previously reported studies, a prospective randomized trial will be required to evaluate its benefit [59].…”

Section: Cryoprecipitatementioning

confidence: 99%

Damage control resuscitation: a practical approach for severely hemorrhagic patients and its effects on trauma surgery

Mizobata

2017

j intensive care

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Coagulopathy observed in trauma patients was thought to be a resuscitation-associated phenomenon. The replacement of lost and consumed coagulation factors was the mainstay in the resuscitation of hemorrhagic shock for many decades. Twenty years ago, damage control surgery (DCS) was implemented to challenge the coagulopathy of trauma. It consists of three steps: abbreviated surgery to control the hemorrhage and contamination, resuscitation in the intensive care unit (ICU), and planned re-operation with definitive surgery. The resuscitation strategy of DCS focused on the rapid reversal of acidosis and prevention of hypothermia through the first two steps. However, direct treatment of coagulopathy was not emphasized in DCS. Recently, better understanding of the pathophysiology of coagulopathy in trauma patients has led to the logical opinion that we should directly address this coagulopathy during major trauma resuscitation. Damage control resuscitation (DCR), the strategic approach to the trauma patient who presents in extremis, consists of balanced resuscitation, hemostatic resuscitation, and prevention of acidosis, hypothermia, and hypocalcemia. In balanced resuscitation, fluid administration is restricted and hypotension is allowed until definitive hemostatic measures begin. The administration of blood products consisting of fresh frozen plasma, packed red blood cells, and platelets, the ratio of which resembles whole blood, is recommended early in the resuscitation. DCR strategy is now the most beneficial measure available to address trauma-induced coagulopathy, and it can change the treatment strategy of trauma patients. DCS is now incorporated as a component of DCR. DCR as a structured intervention begins immediately after rapid initial assessment in the emergency room and progresses through the operating theater into the ICU in combination with DCS. By starting from ground zero with the performance of DCS, DCR allows the trauma surgeon to correct the coagulopathy of trauma. The effect of the reversal of coagulopathy in massively hemorrhagic patients may change the operative strategy with DCS.

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“…These protocols have been traditionally utilized in the context of the massively transfused patients (RBC requirement of ≥10 units in 24 h); however, more recent studies have begun to apply these principles to all trauma patients requiring transfusion. In a 2013 study of 905 trauma patients, the Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) investigators demonstrated an association of decreased mortality within the first 24 h with higher plasma:RBC transfusion ratios and within the first 6 h with higher platelet:RBC transfusion ratios [33].…”

Section: Resuscitationmentioning

confidence: 99%

Orthopedic Approach to the Early Management of Pelvic Injuries

Weaver

Heng

2015

Curr Trauma Rep

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High-energy pelvic fractures in trauma patients cause significant morbidity and mortality. A systematic approach to the early evaluation and management of these patients leads to improved outcomes. The initial care of patients with a displaced pelvic fracture and hemodynamic instability should focus upon three areas: 1) resuscitation, 2) bony stability, and 3) hemorrhage control. Aggressive resuscitation with blood products and clotting factors is paramount. The initial reduction of the pelvic ring and temporary stabilization can be achieved through the use of pelvic sheeting or binder placed in the field or trauma bay. Urgent surgical stabilization with external or internal fixation is often required. Hemorrhage control can be achieved through pelvic packing and/or angioembolization. The initial management of displaced pelvic fractures is multidisciplinary and should involve close collaboration between trauma surgery, orthopedic surgery, anesthesia, and interventional radiology.

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The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study

Cited by 874 publications

References 67 publications

Update from the Abdominal Compartment Society (WSACS) on intra-abdominal hypertension and abdominal compartment syndrome: past, present, and future beyond Banff 2017

Update from the Abdominal Compartment Society (WSACS) on intra-abdominal hypertension and abdominal compartment syndrome: past, present, and future beyond Banff 2017

Damage control resuscitation: a practical approach for severely hemorrhagic patients and its effects on trauma surgery

Orthopedic Approach to the Early Management of Pelvic Injuries

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